Cited by 152Mitochondrial Function and PathologyAdipose Tissue and MetabolismMuscle Physiology and Disorders

Age-Associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training

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Koltai, Erika, Hart, Nikolett, Taylor, Albert W., Goto, Sataro, Ngo, Jenny K., Davies, Kelvin J. A., Radak, Zsolt·2012·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Abstract

A decline in mitochondrial biogenesis and mitochondrial protein quality control in skeletal muscle is a common finding in aging, but exercise training has been suggested as a possible cure. In this report, we tested the hypothesis that moderate-intensity exercise training could prevent the age-associated deterioration in mitochondrial biogenesis in the gastrocnemius muscle of Wistar rats. Exercise training, consisting of treadmill running at 60% of the initial Vo(2max), reversed or attenuated significant age-associated (detrimental) declines in mitochondrial mass (succinate dehydrogenase, citrate synthase, cytochrome-c oxidase-4, mtDNA), SIRT1 activity, AMPK, pAMPK, and peroxisome proliferator-activated receptor gamma coactivator 1-α, UCP3, and the Lon protease. Exercise training also decreased the gap between young and old animals in other measured parameters, including nuclear respiratory factor 1, mitochondrial transcription factor A, fission-1, mitofusin-1, and polynucleotide phosphorylase levels. We conclude that exercise training can help minimize detrimental skeletal muscle aging deficits by improving mitochondrial protein quality control and biogenesis.

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Crossref · 10.1152/ajpregu.00337.2011

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  1. [26]26. Kalyanaraman B, Darley-Usmar V, Davies KJA, Dennery P, Forman HJ, Grisham M, Mann G, Moor Roberts JLJI, Ischiropoulos H. The use of fluorescence probes to measure reactive oxygen and nitrogen species in cell: challenges, potentials and caveats. Free Radic Biol Med 52: 1–6, 2012 [DOI] [PMC free article] [PubMed] [Google Scholar]
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Authors
Koltai, E., Hart, N., Taylor, A. W., Goto, S., Ngo, J. K., Davies, K. J. A., & Radak, Z.
Affiliations
  • Semmelweis University (HU)
  • University of Southern California (US)
Corresponding author
Radak, Zsolt
Venue
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Published
2012-07-15
Volume
303
Issue
2
Pages
R127-R134
ISSN
  • 0363-6119 (ISSN-L)
  • 1522-1490
OpenAlex
W2136544814
Cited by
152
References
60
Citations by year
2026: 4 · 2025: 8 · 2024: 2 · 2023: 12 · 2022: 4 · 2021: 16 · 2020: 10 · 2019: 14 · 2018: 19 · 2017: 11 · 2016: 9 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 4
FWCI
5.53
Type
journal article
Language
en
Open access
Locations
  • American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Environmental Health Sciences (3R01-ES 003598-22S2, R01ES003598)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
exercise training, mitochondrial biogenesis, mitochondrial protein quality control, skeletal muscle aging, gastrocnemius, SIRT1, AMPK, PGC-1α, UCP3, Lon protease, mitofusin 1, mitochondrial fission, mitochondrial mass, mitochondrial DNA, succinate dehydrogenase, citrate synthase, cytochrome c oxidase, NRF1, TFAM, treadmill running, Wistar rats
MeSH terms
Adaptation, Physiological, Aging, Animals, Male, Membrane Proteins, Mitochondria, Muscle, Physical Conditioning, Animal, Transcription Factors, Rats, Wistar, Muscle, Skeletal, Models, Animal, Mitochondrial Proteins, Nuclear Respiratory Factor 1, Rats

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