The relationship between mitochondrial function and walking performance in older adults with a wide range of physical function
Open accessAbstract
Background Age related declines in walking performance may be partly attributable to skeletal muscle mitochondrial dysfunction as mitochondria produce over 90% of ATP needed for movement and the capacity for oxidative phosphorylation decreases with age.Methods Participants were from two studies: an ancillary to the Lifestyle Interventions and Independence for Elders (LIFE) Study (n=33), which recruited lower functioning participants (Short Physical Performance Battery [SPPB], 7.8±1.2), and the Study of Energy and Aging-Pilot (SEA, n=29), which enrolled higher functioning (SPPB, 10.8±1.4). Physical activity was measured objectively using the Actigraph accelerometer (LIFE) and SenseWear Pro armband (SEA). Phosphocreatine recovery following muscle contraction of the quadriceps was measured using (31)P magnetic resonance spectroscopy and ATPmax (mM ATP/s) was calculated. Walking performance was defined as time (s) to walk 400m at a usual-pace. The cross-sectional association between mitochondrial function and walking performance was assessed using multivariable linear regression.Results Participants were 77.6±5.3years, 64.2% female and 67.2% white. ATPmax was similar in LIFE vs. SEA (0.52±0.14 vs. 0.55±0.14, p=0.31), despite different function and activity levels (1.6±2.2 vs.77.4±73.3min of moderate activity/day, p<0.01). Higher ATPmax was related to faster walk-time in SEA (r(2)=0.19, p=0.02,); but not the LIFE (r(2)<0.01, p=0.74) cohort.Conclusions Mitochondrial function was associated with walking performance in higher functioning, active older adults, but not lower functioning, sedentary older adults.
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Loss of mitochondrial energetics in sub-optimal aging contributes to slower walking speed, fatigability, multimorbidity, frailty and sarcopenia.
“recent studies have shown that loss of mitochondrial energetics in sub-optimal aging contributes to slower walking speed [[355], [356], [357], [358]], fatigability [359], multimorbidity [360], frailty [361] and sarcopenia [345,362].”
From Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR) (2025) · cites this paper as [357]
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- Authors
- Santanasto, A. J., Coen, P. M., Glynn, N. W., Conley, K. E., Jubrias, S. A., Amati, F., Strotmeyer, E. S., Boudreau, R. M., Goodpaster, B. H., & Newman, A. B.
- Affiliations
- University of Pittsburgh (US)
- University of Washington (US)
- Corresponding author
- Newman, Anne B.
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 81
- Pages
- 1-7
- ISSN
- 0531-5565 (ISSN-L)
- PMC
- PMC5483943
- OpenAlex
- W2337039471
- Cited by
- 47
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 10 · 2023: 5 · 2022: 2 · 2021: 9 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 1
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Experimental Gerontology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Funders
- National Institute on Aging/National Institutes of Health (1RC2AG036594-01 – SEA-P)
- NIA (T32-AG-000181)
- National Institute on Aging (AG044437, UO1 AG22376, K07AG3587)
- National Institutes of Health
- National Heart, Lung and Blood Institute (3U01AG022376-05A2S)
- Intramural Research Program, National Institute on Aging, NIH
- Claude D. Pepper Older Americans Independence Centers at the University of Florida (1 P30 AG028740)
- Wake Forest University (1 P30 AG21332)
- Tufts University (1P30AG031679)
- University of Pittsburgh (P30 AG024827)
- Yale University (P30AG021342)
- NIH/NCRR CTSA at Stanford University (UL1 RR025744)
- Boston Rehabilitation Outcomes Center (1R24HD065688-01A1)
- Department of Veterans Affairs
- U.S. Department of Agriculture (58–1950–0-014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- mitochondrial function, walking performance, older adults, physical function, skeletal muscle, oxidative phosphorylation, phosphocreatine recovery, physical activity, sedentary aging
- MeSH terms
- Walk Test, Aged, Aged, 80 and over, Aging, Cross-Sectional Studies, Female, Humans, Life Style, Male, Mitochondria, Muscle, Muscle Contraction, Magnetic Resonance Spectroscopy, United States, Multivariate Analysis, Linear Models, Walking, Mobility Limitation, Quadriceps Muscle
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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