Influence of Sarcopenia on the Development of Physical Disability: The Cardiovascular Health Study
Abstract
OBJECTIVES: To examine the temporal relationship between sarcopenia and disability in elderly men and women. DESIGN: Cardiovascular Health Study, a longitudinal study of cardiovascular disease and its risk factors in older people. SETTING: Four U.S. communities. PARTICIPANTS: Five thousand thirty‐six men and women aged 65 and older. MEASUREMENTS: Whole‐body skeletal muscle mass was measured at baseline, and subjects were classified as having normal muscle mass, moderate sarcopenia, or severe sarcopenia based on previously established thresholds. Disability was measured via questionnaire at baseline in up to eight annual follow‐up examinations. The cross‐sectional relationship between sarcopenia and prevalent disability at baseline was examined using logistic regression models. The longitudinal relation between sarcopenia and incident disability over 8 years of follow‐up was examined using Cox proportional hazards models. RESULTS: At baseline, the likelihood of disability was 79% greater in those with severe sarcopenia ( P <.001) but was not significantly greater in those with moderate sarcopenia ( P= .38) than in those with normal muscle mass. During the 8‐year follow‐up, the risk of developing disability was 27% greater in those with severe sarcopenia ( P= .006) but was not statistically greater in those with moderate sarcopenia ( P= .23) than in those with normal muscle mass. CONCLUSION: Severe sarcopenia was a modest independent risk factor for the development of physical disability. The effect of sarcopenia on disability was considerably smaller in the longitudinal analysis than in the cross‐sectional analysis.
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Severe sarcopenia is associated with a 79% greater likelihood of disability.
“Severe sarcopenia is also associated with a 79% greater likelihood of disability [6].”
From Protecting muscle mass and function in older adults during bed rest (2010) · cites this paper as [6]
Many older adults are already in a sarcopenic state prior to a period of bed rest or illness/injury-induced inactivity.
“i) many older adults are already in a sarcopenic state prior to a period of bed rest or illness/injury-induced inactivity”
From Protecting muscle mass and function in older adults during bed rest (2010) · cites this paper as [6]
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- Authors
- Janssen, I.
- Affiliations
- Queen's University (CA)
- Corresponding author
- Janssen, Ian
- ORCID
- Janssen, Ian
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2005-11-17
- Volume
- 54
- Issue
- 1
- Pages
- 56-62
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1559843211
- Cited by
- 459
- References
- 29
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 19 · 2023: 17 · 2022: 27 · 2021: 23 · 2020: 26 · 2019: 23 · 2018: 28 · 2017: 17 · 2016: 27 · 2015: 21 · 2014: 42 · 2013: 33 · 2012: 40
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- sarcopenia, physical disability, skeletal muscle mass, older adults, disability risk factors, incident disability, temporal relations, severe sarcopenia, Cardiovascular Health Study
- MeSH terms
- Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Aging, Body Composition, Disability Evaluation, Female, Follow-Up Studies, Health Status, Humans, Male, Muscular Atrophy, Prospective Studies, Severity of Illness Index, Sex Factors, Socioeconomic Factors
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