Cited by 160Telomeres, Telomerase, and SenescenceT-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

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Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

Frasca, Daniela, Diaz, Alain, Romero, Maria, Blomberg, Bonnie B.·2017·Experimental Gerontology

DOI 10.1016/j.exger.2016.12.001

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Abstract

The percentage of late/exhausted memory (LM) B cells increases with age and we show here that this is associated with a lower influenza vaccine response. To identify novel contributors to the phenotypic and functional changes observed in aged B cells, we sorted the major peripheral B cell subsets [naïve, IgM memory, switched memory (swIg) and late/exhausted memory (LM)] and determined their percentages in the peripheral blood as well as their level of immune activation by measuring basal levels of expression of multiple senescence-associated secretory phenotype (SASP) markers, such as pro-inflammatory cytokines (TNF-α/IL-6/IL-8), inflammatory micro-RNAs (miRs, miR-155/16/93), cell cycle regulators (p16 INK4). We found that only memory B cells express SASP markers, and especially the LM B cell subset, which is also showing spontaneous activation of AMP-activated protein kinase (AMPK), the energy sensing enzyme which is ubiquitously expressed in mammalian cells. LM B cells, but not IgM memory B cells, activate a p38MAPK signaling pathway, downstream of AMPK, leading to the expression of SASP mediators, while class switch recombination is downregulated. These data show that some B cell subsets are more inflammatory than others, that they are pre-activated and that this signaling through metabolic pathways is associated with a senescence phenotype, demonstrating for the first time in human B lymphocytes the link between aging, cellular senescence, SASP and metabolism.

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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
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Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature · doi:10.1038/nature11861 · Cited by 1,676
Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275
Systemic inflammation and disease progression in Alzheimer disease
Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bb95 · Cited by 1,139
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
Freund, A., Patil, C. K., & Campisi, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.69 · Cited by 1,039
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Hao, Y., O'Neill, P., Naradikian, M. S., Scholz, J. L., & Cancro, M. P. (2011) · Blood · doi:10.1182/blood-2011-01-330530 · Cited by 622
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Wei, C., Anolik, J. H., Cappione, A., Zheng, B., Pugh-Bernard, A. E., Brooks, J. C., Lee, E.-H., MILNER, E. C. B., & Sanz, I. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6624 · Cited by 605

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Authors: Frasca, D., Diaz, A., Romero, M., & Blomberg, B. B.
Affiliations: University of Miami (US)
Corresponding author: Frasca, Daniela
ORCID: Frasca, Daniela
Romero, Maria
Blomberg, Bonnie B.
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2017-01
Volume: 87
Issue: Pt A
Pages: 113-120
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/j.exger.2016.12.001
OpenAlex: W2559849490
Cited by: 160
References: 57
Citations by year: 2026: 10 · 2025: 17 · 2024: 21 · 2023: 14 · 2022: 21 · 2021: 30 · 2020: 15 · 2019: 13 · 2018: 8 · 2017: 10
FWCI: 8.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Funders: NIH (R01 AG032576, R21 AI096446, R21 AG042826, R56 AG032576)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: senescence-associated secretory phenotype, cellular senescence, B cell aging, influenza vaccine response, AMPK, p38 MAPK signaling, metabolic signaling, class switch recombination, p16INK4, inflammatory cytokines, human B lymphocytes
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Cell Line, Female, Hemagglutination Inhibition Tests, Humans, Male, Middle Aged, Biomarkers, B-Lymphocyte Subsets, Cytokines, Cellular Senescence, MAP Kinase Signaling System, MicroRNAs, Metabolic Networks and Pathways, AMP-Activated Protein Kinases

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Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

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