Cited by 411Immune responses and vaccinationsImmunotherapy and Immune ResponsesImmune Response and Inflammation

Vaccination in the elderly: The challenge of immune changes with aging

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Ciabattini, Annalisa, Nardini, Christine, Santoro, Francesco, Garagnani, Paolo, Franceschi, Claudio, Medaglini, Donata·2018·Seminars in Immunology

Abstract

The unprecedented increase of life expectancy challenges society to protect the elderly from morbidity and mortality making vaccination a crucial mean to safeguard this population. Indeed, infectious diseases, such as influenza and pneumonia, are among the top killers of elderly people in the world. Elderly individuals are more prone to severe infections and less responsive to vaccination prevention, due to immunosenescence combined with the progressive increase of a proinflammatory status characteristic of the aging process (inflammaging). These factors are responsible for most age-related diseases and correlate with poor response to vaccination. Therefore, it is of utmost interest to deepen the knowledge regarding the role of inflammaging in vaccination responsiveness to support the development of effective vaccination strategies designed for elderly. In this review we analyse the impact of age-associated factors such as inflammaging, immunosenescence and immunobiography on immune response to vaccination in the elderly, and we consider systems biology approaches as a mean for integrating a multitude of data in order to rationally design vaccination approaches specifically tailored for the elderly.

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Authors
Ciabattini, A., Nardini, C., Santoro, F., Garagnani, P., Franceschi, C., & Medaglini, D.
Affiliations
  • University of Siena (IT)
  • Karolinska Institutet (SE)
  • Istituto delle Scienze Neurologiche di Bologna (IT)
Corresponding author
  • Franceschi, Claudio
  • Medaglini, Donata
Venue
Seminars in Immunology
Publisher
Elsevier BV
Published
2018-12
Volume
40
Pages
83-94
ISSN
1044-5323 (ISSN-L)
OpenAlex
W2903322118
Cited by
411
References
152
Citations by year
2026: 39 · 2025: 36 · 2024: 53 · 2023: 63 · 2022: 75 · 2021: 74 · 2020: 50 · 2019: 20
FWCI
3.68
Type
journal article
Language
en
Open access
Locations
  • Seminars in Immunology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • Use Siena air (University of Siena) (submittedVersion, cc-by-nc-nd)
Funders
  • Commission of the European Communities, Seventh Framework Programme (HEALTH-2011-280873)
  • Advanced Immunization Technologies (602757)
  • Horizon 2020 Framework Programme (634821)
  • Fondazione Cassa di Risparmio delle Province Lombarde (2015–0564)
  • Ministry of Education and Science of the Russian Federation (074-02-2018-33)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
immunosenescence, inflammaging, vaccine response, influenza vaccination, pneumococcal vaccination, age-related diseases, systems biology
MeSH terms
Immunosenescence, Aged, Aging, Animals, Humans, Inflammation, Vaccination, Systems Biology, Precision Medicine, Datasets as Topic

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