The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Axon degeneration in Parkinson's disease
Open accessAbstract
Parkinson's disease (PD) is the most common neurodegenerative disease of the basal ganglia. Like other adult-onset neurodegenerative disorders, it is without a treatment that forestalls its chronic progression. Efforts to develop disease-modifying therapies to date have largely focused on the prevention of degeneration of the neuron soma, with the tacit assumption that such approaches will forestall axon degeneration as well. We herein propose that future efforts to develop neuroprotection for PD may benefit from a shift in focus to the distinct mechanisms that underlie axon degeneration. We review evidence from human post-mortem studies, functional neuroimaging, genetic causes of the disease and neurotoxin models that axon degeneration may be the earliest feature of the disease, and it may therefore be the most appropriate target for early intervention. In addition, we present evidence that the molecular mechanisms of degeneration of axons are separate and distinct from those of neuron soma. Progress is being made in understanding these mechanisms, and they provide possible new targets for therapeutic intervention. We also suggest that the potential for axon re-growth in the adult central nervous system has perhaps been underestimated, and it offers new avenues for neurorestoration. In conclusion, we propose that a new focus on the neurobiology of axons, their molecular pathways of degeneration and growth, will offer novel opportunities for neuroprotection and restoration in the treatment of PD and other neurodegenerative diseases.
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1 retracted
RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
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Cited by
Selective neuronal vulnerability in Parkinson disease
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“Quality control of axonal mitochondria, however, is of particular interest because axonal degeneration precedes the loss of the soma in neuro degenerative diseases, such as PD (Burke and O’Malley, 2013).”
Determinants of dopaminergic neuron loss in Parkinson's disease
Surmeier, D. J. (2018) · The FEBS Journal · doi:10.1111/febs.14607 · Cited by 444
Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism
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Metadata
- Authors
- Burke, R. E., & O'Malley, K.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 246
- Pages
- 72-83
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2070049573
- Cited by
- 493
- References
- 123
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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