Pattern recognition receptors and central nervous system repair

The plant immune system

Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326

Tolerance, Danger and the Extended Family

Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 5,107

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080

Recent advances on signaling pathways and their inhibitors in spinal cord injury

Ding, Y., & Chen, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116938 · Cited by 29

Acidification changes affect the inflammasome in human nucleus pulposus cells

Brand, F. J., Forouzandeh, M., Kaur, H., Travascio, F., & Vaccari, J. P. D. R. (2016) · Journal of Inflammation · doi:10.1186/s12950-016-0137-0 · Cited by 29

Peripheral blood expression levels of inflammasome complex components in two different focal epilepsy syndromes

Ulusoy, C. A., Vanlı-Yavuz, E. N., Şanlı, E., Timirci‐Kahraman, Ö., Yılmaz, V., Bebek, N., Küçükali, C. İ., Baykan, B. B., & Tüzün, E. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577343 · Cited by 29

Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses

Fan, R., Zhang, Y., Botchway, B. O. A., & Liu, X. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02509-4 · Cited by 30

Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake

Marcos, J. L., Olivares-Barraza, R., Ceballo, K., Wastavino, M., Ortiz, V., Riquelme, J., Martínez-Pinto, J., Muñoz, P., Cruz, G., & Sotomayor‐Zárate, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021468 · Cited by 33

SNP detection of TLR8 gene, association study with susceptibility/resistance to GCRV and regulation on mRNA expression in grass carp, Ctenopharyngodon idella

Su, J., Su, J., Shang, X., Wan, Q., Chen, X., & Rao, Y. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.12.005 · Cited by 28

Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation

Conant, K. E., Daniele, S. G., Bozzelli, P. L., Abdi, T., Edwards, A. A., Szklarczyk, A., Olchefske, I., Ottenheimer, D. J., & Maguire‐Zeiss, K. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0827-4 · Cited by 29

Single-cell Sequence Analysis Combined with Multiple Machine Learning to Identify Markers in Sepsis Patients: LILRA5

Ning, J., Fan, X., Sun, K., Wang, X., Li, H., Jia, K., & Ma, C. (2023) · Inflammation · doi:10.1007/s10753-023-01803-8 · Cited by 26

Hypothalamic Microglial Heterogeneity and Signature under High Fat Diet–Induced Inflammation

Mendes, N. F., Jara, C. P., Zanesco, A. M., & ARAUJO, E. P. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052256 · Cited by 28

Dorsal root ganglion toll-like receptor 4 signaling contributes to oxaliplatin-induced peripheral neuropathy

Illias, A. M., Yu, K., Hwang, S., Solis, J., Zhang, H., Velasquez, J. F., Cata, J. P., & Dougherty, P. M. (2021) · Pain · doi:10.1097/j.pain.0000000000002454 · Cited by 31

Sepsis Encephalopathy Is Partly Mediated by miR370-3p-Induced Mitochondrial Injury but Attenuated by BAM15 in Cecal Ligation and Puncture Sepsis Male Mice

Hiengrach, P., Visitchanakun, P., Tongchairawewat, P., Tangsirisatian, P., Jungteerapanich, T., Ritprajak, P., Wannigama, D. L., Tangtanatakul, P., & Leelahavanichkul, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105445 · Cited by 27

The DMT and Psilocin Treatment Changes CD11b+ Activated Microglia Immunological PhenotypePreprint

Kozłowska, U., Klimczak, A., Wiatr, K., & Figiel, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.07.434103 · Cited by 27

NLRP3 inflammasome and gut microbiota–brain axis: A new perspective on white matter injury after intracerebral hemorrhage

Cai, X., Cai, X., Xie, Q., Xiao, X., Li, T., Zhou, T., & Sun, H. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00917 · Cited by 27

Liver inflammation at the time of spinal cord injury enhances intraspinal pathology, liver injury, metabolic syndrome and locomotor deficits

Goodus, M. T., Carson, K. E., Sauerbeck, A. D., Dey, P., Alfredo, A. N., Popovich, P. G., Bruno, R. S., & McTigue, D. M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113725 · Cited by 28

Role of G Protein-Coupled Receptors in Microglial Activation: Implication in Parkinson’s Disease

Gu, C., Chen, Y., Chen, Y., Liu, C., Zhu, Z., & Wang, M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.768156 · Cited by 26

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2 − in LPS/IFNγ activated glioma cells

MAZZIO, E. A., Bauer, D., Mendonca, P., Taka, E., & Soliman, K. F. A. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.11.012 · Cited by 26

Potential role of CSF cytokine profiles in discriminating infectious from non-infectious CNS disorders

Fortuna, D., Hooper, D. C., Roberts, A. L., Harshyne, L. A., Nagurney, M., & Curtis, M. T. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205501 · Cited by 25

Levels of caspase-1 in cerebrospinal fluid of patients with traumatic brain injury: correlation with intracranial pressure and outcome

Pérez‐Bárcena, J., Crespı́, C., Frontera, G., Llompart‐Pou, J. A., Salazar, O., Goliney, V. G., Ibáñez, J., Bullock, M. R., & Vaccari, J. P. D. R. (2020) · Journal of neurosurgery · doi:10.3171/2020.2.jns193079 · Cited by 26

CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages

Zaidi, N. E., Shazali, N. A. H., Leow, T. C., Osman, M. A., Ibrahim, K., Cheng, W.-H., Lai, K., & Rahman, N. M. A. N. A. (2022) · Cells · doi:10.3390/cells11223556 · Cited by 25

Progression of mesenchymal stem cell regulation on imbalanced microenvironment after spinal cord injury

Liu, Y., Zhao, C., Zhang, R., Pang, Y., Li, L., & Feng, S. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03914-x · Cited by 25

Immunity, Vascular Aging and Stroke

Louka, A. M., Sagris, D., & Ntaios, G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220103101700 · Cited by 26

Microglial Endocannabinoid Signalling in AD

Scipioni, L., Ciaramellano, F., Carnicelli, V., Leuti, A., Lizzi, A. R., Dominicis, N. D., Oddi, S., & Maccarrone, M. (2022) · Cells · doi:10.3390/cells11071237 · Cited by 26

Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease

Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13181554 · Cited by 26

Injury programs shape glioblastoma

Brooks, L. J., Ragdale, H. S., Hill, C. S., Clements, M., & Parrinello, S. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.08.006 · Cited by 22

Chromosomal and gonadal factors regulate microglial sex effects in the aging brain

Ocañas, S. R., Ansere, V. A., Kellogg, C. M., Isola, J. V. V., Chucair‐Elliott, A. J., & Freeman, W. M. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.02.008 · Cited by 25

Human microglial models to study host–virus interactions

McMillan, R. E., Wang, E. Y., Carlin, A. F., & Coufal, N. G. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114375 · Cited by 24

Chronic intermittent ethanol and lipopolysaccharide exposure differentially alter Iba1‐derived microglia morphology in the prelimbic cortex and nucleus accumbens core of male Long‐Evans rats

Siemsen, B. M., Landin, J. D., McFaddin, J. A., Hooker, K. N., Chandler, L. J., & Scofield, M. D. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24683 · Cited by 26

Microglia: Ally and Enemy in Deep Space

Rienecker, K. D. A., Paladini, M. S., Grue, K. A., Krukowski, K., & Rosi, S. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.036 · Cited by 25

Cytokines and chemokines profile in encephalitis patients: A meta-analysis

Khaboushan, A. S., Pahlevan‐Fallahy, M., Shobeiri, P., Teixeira, A. L., & Rezaei, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273920 · Cited by 26

Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1

Weng, J.-Y., Chen, X.-X., Wang, X., Ye, H.-E., Wu, Y., Sun, W., Liang, L., Duan, W.-J., Kurihara, H., Huang, F., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01095-6 · Cited by 23

Advances of Genome Editing with CRISPR/Cas9 in Neurodegeneration: The Right Path towards Therapy

Klinkovskij, A., Shepelev, M. V., Isaakyan, Y. A., Aniskin, D., & Ulasov, I. V. (2023) · Biomedicines · doi:10.3390/biomedicines11123333 · Cited by 24

Divergent age-dependent peripheral immune transcriptomic profile following traumatic brain injury

Hazy, A., Bochicchio, L. A., Oliver, A., Xie, E., Geng, S., Brickler, T., Xie, H., Li, L., Allen, I. C., & Theus, M. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-45089-z · Cited by 22

PRR-Mediated Immune Response and Intestinal Flora Profile in Soybean Meal-Induced Enteritis of Pearl Gentian Groupers, Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂

Zhang, W., Tan, B., Deng, J., Yang, Q., Chi, S., Pang, A., Yu, X., Liu, Y., & Zhang, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.814479 · Cited by 23

Microglial CD74 Expression Is Regulated by TGFβ Signaling

Jahn, J., Bollensdorf, A., Kalischer, C., Piecha, R., Weiß-Müller, J., Potru, P. S., Ruß, T., & Spittau, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810247 · Cited by 22

Role of DAMPs and cell death in autoimmune diseases: the example of multiple sclerosis

Land, W. G. (2023) · Genes and Immunity · doi:10.1038/s41435-023-00198-8 · Cited by 23

Functions of a C‐type lectin with a single carbohydrate‐recognition domain in the innate immunity and movement of the red flour beetle, Tribolium castaneum

Li, J., Bi, J., Zhang, P., Wang, Z., Zhong, Y., Xu, S., Wang, L., & Li, B. (2020) · Insect Molecular Biology · doi:10.1111/imb.12680 · Cited by 22

Living in a Hostile World: Inflammation, New Drug Development, and Coronavirus

Dobson, G. P., Biroš, E., Letson, H. L., & Morris, J. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.610131 · Cited by 22

Understanding the influence of TLR-mediated immune system on necroptosis-induced neurodegeneration in Parkinson’s disease

Jadhav, V. S., & Khatri, D. K. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102872 · Cited by 22

Phosphoinositide-3-Kinase γ Is Not a Predominant Regulator of ATP-Dependent Directed Microglial Process Motility or Experience-Dependent Ocular Dominance Plasticity

Whitelaw, B. S., Matei, E. K., & Majewska, A. K. (2020) · eNeuro · doi:10.1523/eneuro.0311-20.2020 · Cited by 20

Pathways linking Alzheimer’s disease risk genes expressed highly in microglia

Hodges, A. K., Piers, T. M., Collier, D., Cousins, O., & Pocock, J. M. (2021) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2020.60 · Cited by 21

Serum Caspase-1 as an Independent Prognostic Factor in Traumatic Brain Injured Patients

Pérez‐Bárcena, J., Pilar, J. R., Salazar, O., Crespı́, C., Frontera, G., Novo, M. A., Guardiola, B., Llompart‐Pou, J. A., Ibáñez, J., & Vaccari, J. P. D. R. (2021) · Neurocritical Care · doi:10.1007/s12028-021-01340-y · Cited by 21

The role of pyroptosis and its crosstalk with immune therapy in breast cancer

Wu, L., Lu, H., Pan, Y., Liu, C., Wang, J., Chen, B., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.973935 · Cited by 24

Proof-of-Principle Study of Inflammasome Signaling Proteins as Diagnostic Biomarkers of the Inflammatory Response in Parkinson’s Disease

Ranaldi, E. D. L. R. M. C., Nuytemans, K., Martinez, A., Luca, C. C., Keane, R. W., & Vaccari, J. P. D. R. (2023) · Pharmaceuticals · doi:10.3390/ph16060883 · Cited by 22

HIF ‐1α promotes astrocytic production of macrophage migration inhibitory factor following spinal cord injury

Hao, H., Hou, Y., Li, A., Niu, L., Li, S., He, B., Zhang, X., Song, H., Cai, R., Zhou, Y., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14300 · Cited by 20

Brain-derived extracellular vesicles mediate systemic coagulopathy and inflammation after traumatic brain injury

Li, F., Li, L., Peng, R., Liu, C., Liu, X., Liu, Y., Wang, C., Xu, J., Zhang, Q., Yang, G., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111674 · Cited by 20

The multitaskers of the brain: glial responses to viral infections and associated post-infectious neurologic sequelae

Davé, V. A., & Klein, R. S. (2023) · Glia · doi:10.1002/glia.24294 · Cited by 29

Ischemic stroke and diabetes: a TLR4-mediated neuroinflammatory perspective

Oo, T. T. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02441-9 · Cited by 22

Modulation of PI3K/AKT signaling and DFT modeling via selected pharmaceutical compounds attenuates carrageenan-induced inflammation and oxidative stress in rats

Abdrabou, A., Kamal, M., Alharbi, H. Y., Aljohani, M. S., El‐Atawy, M. A., & Kishta, M. S. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03689-1 · Cited by 20

The Therapeutic Potential of Butyrate and Lauric Acid in Modulating Glial and Neuronal Activity in Alzheimer’s Disease

Wtpsk, S., Oikari, L. E., Bharadwaj, P., Jayasena, V., Martins, R. N., & Fernando, W. M. A. D. B. (2025) · Nutrients · doi:10.3390/nu17142286 · Cited by 23

Expression and localization of absent in melanoma 2 in the injured spinal cord

Hu, J., Lü, H., Wang, S., Guo, X., Tang, J., Ding, S., Shen, L., Wang, R., & Ma, S. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.245481 · Cited by 20

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

Morozzi, G., Rothen, J., Toussaint, G., de Lange, K., Westritschnig, K., Doelemeyer, A., Ueberschlag-Pitiot, V., Kahle, P., Lambert, C., Obrecht, M., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103434 · Cited by 21

Kv1.3 K + Channel Physiology Assessed by Genetic and Pharmacological Modulation

Varanita, T., Angi, B., Scattolini, V., & Szabó, I. (2022) · Physiology · doi:10.1152/physiol.00010.2022 · Cited by 20

Nicotinic regulation of microglia: potential contributions to addiction

Soares, A. R., & Picciotto, M. R. (2023) · Journal of Neural Transmission · doi:10.1007/s00702-023-02703-9 · Cited by 25

Stress-Induced NLRP3 Inflammasome in Human Diseases

Alcocer‐Gómez, E., Castejón‐Vega, B., & Cordero, M. D. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.02.002 · Cited by 19

Epidemiology, Risk Factors, and Biomarkers of Post-Traumatic Epilepsy: A Comprehensive Overview

Kazis, D. A., Chatzikonstantinou, S., Ciobica, A. S., Kamal, F. Z., Burlui, V., Călin, G., & Mavroudis, I. A. (2024) · Biomedicines · doi:10.3390/biomedicines12020410 · Cited by 19

Neurotropic RNA Virus Modulation of Immune Responses within the Central Nervous System

Vazquez, C., & Jurado, K. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23074018 · Cited by 19

Survival motor neuron protein deficiency alters microglia reactivity

Khayrullina, G., Alipio‐Gloria, Z. A., Deguise, M., Gagnon, S., Chehadé, L., Stinson, M. W., Belous, N., Bergman, E. M., Lischka, F. W., Rotty, J. D., et al. (2022) · Glia · doi:10.1002/glia.24177 · Cited by 18

Thrombin acts as inducer of proinflammatory macrophage migration inhibitory factor in astrocytes following rat spinal cord injury

Yang, T., Jiang, H., Luo, X., Hou, Y., Li, A., He, B., Zhang, X., Hao, H., Song, H., Cai, R., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02488-w · Cited by 19

Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury

Shi, J., Tang, J., Jin, X., Jiang, N., Yang, Y., Chen, H., Han, Y., & Fu, X. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1515164 · Cited by 21

Role and mechanism of the nod-like receptor family pyrin domain-containing 3 inflammasome in oral disease

Lv, K., Wang, G., Shen, C., Zhang, X., & Yao, H. (2018) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2018.10.003 · Cited by 19

An in vitro model for studying CNS white matter: functional properties and experimental approaches

Bijland, S., Thomson, G., Euston, M., Michail, K., Thümmler, K., Mücklisch, S., Crawford, C. L., Barnett, S. C., McLaughlin, M., Anderson, T. J., et al. (2019) · F1000Research · doi:10.12688/f1000research.16802.1 · Cited by 17

Polyamine Transport Protein PotD Protects Mice against Haemophilus parasuis and Elevates the Secretion of Pro-Inflammatory Cytokines of Macrophage via JNK–MAPK and NF–κB Signal Pathways through TLR4

Dai, K., Ma, X., Yang, Z. L., Chang, Y., Cao, S., Zhao, Q., Huang, X., Wu, R. J., Huang, Y., Yan, Q., et al. (2019) · Vaccines · doi:10.3390/vaccines7040216 · Cited by 19

White Matter Lesions in the Perinatal Period

Haynes, R. L., & Folkerth, R. D. (2018) · Wiley eBooks · doi:10.1002/9781119013112.ch21 · Cited by 19

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer’s disease

Seplovich, G., Bouchi, Y., Vaccari, J. P. D. R., Pareja, J. C. M., Reisner, A., Blackwell, L. S., Mechref, Y. S., Wang, K., Tyndall, J. A., Tharakan, B., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00107 · Cited by 21

Targeting Neuroinflammation in Central Nervous System Diseases by Oral Delivery of Lipid Nanoparticles

Zou, Y., Zhang, J., Chen, L., Xu, Q., Yao, S., & Chen, H. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17030388 · Cited by 19

Association of pyroptosis and severeness of COVID-19 as revealed by integrated single-cell transcriptome data analysis

Xu, Q., Yang, Y., Zhang, X., & Cai, J. J. (2022) · ImmunoInformatics · doi:10.1016/j.immuno.2022.100013 · Cited by 18

Neuroinflammatory Response in Reward-Associated Psychostimulants and Opioids: A Review

Karimi‐Haghighi, S., Chavoshinezhad, S., Mozafari, R., Noorbakhsh, F., Borhani‐Haghighi, A., & Haghparast, A. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01223-6 · Cited by 19

The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis

Bai, P., Zhu, R., Wang, P., Jiang, F., Jin, Z., Yao, Y., Zhao, C., Liang, Z., Wang, M., Liu, B., et al. (2022) · Pharmacology Research & Perspectives · doi:10.1002/prp2.972 · Cited by 18

The inflammasome pathway: A key player in ocular surface and anterior segment diseases

Mandell, J. T., Vaccari, J. P. D. R., Sabater, A. L., & Galor, A. (2022) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2022.06.003 · Cited by 18

A pattern recognition receptor C‐type lectin TcCTL14 contributes to immune response and development in the red flour beetle, Tribolium castaneum

Zhang, Y., Ai, H., Wang, Y., Zhang, P., Du, L., Wang, J., Wang, S., Gao, H., & Li, B. (2022) · Insect Science · doi:10.1111/1744-7917.13161 · Cited by 18

MiR-124 Reduced Neuroinflammation after Traumatic Brain Injury by Inhibiting TRAF6

Yang, Y., Ye, Y., Fan, K., Luo, J., Yang, Y., & Ma, Y. (2023) · NeuroImmunoModulation · doi:10.1159/000528502 · Cited by 18

Increased production of inflammatory cytokines by circulating monocytes in mesial temporal lobe epilepsy: A possible role in drug resistance

Milano, C., Montali, M., Barachini, S., Burzi, I. S., Pratesi, F., Petrozzi, L., Chico, L., Morganti, R., Gambino, G., Rossi, L., et al. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578272 · Cited by 20

Protein biomarkers of epileptogenicity after traumatic brain injury

Agoston, D., & Kamnaksh, A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.017 · Cited by 15

The immunological role of oligodendrocytes: beyond myelin maintenance

Pasquini, J. M., & Correale, J. D. (2025) · Discovery Immunology · doi:10.1093/discim/kyaf005 · Cited by 16

Psoriasis, Is It a Microdamage of Our “Sixth Sense”? A Neurocentric View

Sonkodi, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911940 · Cited by 16

Evolution of the Major Components of Innate Immunity in Animals

Silva, R. C. M. C., & Gomes, F. M. (2024) · Journal of Molecular Evolution · doi:10.1007/s00239-024-10155-2 · Cited by 18

Quantification of Circulating Cell-Free DNA in Idiopathic Parkinson’s Disease Patients

Wojtkowska, M., Karczewska, N., Pacewicz, K., Pacak, A. M., Kopeć, P., Florczak‐Wyspianska, J., Popławska-Domaszewicz, K., Małkiewicz, T., & Sokół, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052818 · Cited by 17

Primary mitochondrial diseases: The intertwined pathophysiology of bioenergetic dysregulation, oxidative stress and neuroinflammation

Aguilar, K., Jakubek, P., Antonio Zorzano, A., & Wieckowski, M. R. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14217 · Cited by 19

Toll-Like Receptor 4 Signaling in Focal Cerebral Ischemia: a Focus on the Neurovascular Unit

Famakin, B. M., & Vemuganti, R. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01906-5 · Cited by 18

Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate

Jesudasan, S. J. B., Gupta, S. J., Churchward, M. A., Todd, K. G., & Winship, I. R. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.634020 · Cited by 16

SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in Pathogenesis

Gugliandolo, A., Chiricosta, L., Calcaterra, V., Biasin, M., Cappelletti, G., Carelli, S., Zuccotti, G., Avanzini, M. A., Bramanti, P., Pelizzo, G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158059 · Cited by 17

A possible role of tachykinin-related peptide on an immune system activity of mealworm beetle, Tenebrio molitor L.

Urbański, A., Konopińska, N., Lubawy, J., Walkowiak‐Nowicka, K., Marciniak, P., & Rolff, J. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104065 · Cited by 16

Transcriptome of microglia reveals a species‐specific expression profile in bovines with conserved and new signature genes

Tavares-Gomes, L., Monney, C., Neuhaus, G., Francisco, D. M. F., Solis, D., Summerfield, A., Erny, D., Jagannathan, V., & Oevermann, A. (2021) · Glia · doi:10.1002/glia.24002 · Cited by 17

Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death

Zhang, Y. W., Yang, X., Liu, J., Pan, Y., Zhang, M., & Chen, L. (2022) · Molecules · doi:10.3390/molecules27185925 · Cited by 16

Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease

Saavedra, J., Nascimento, M., Liz, M. A., & Cardoso, I. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1036123 · Cited by 16

Activation of inflammasomes and their effects on neuroinflammation at the microelectrode-tissue interface in intracortical implants

Franklin, M. E., Bennett, C., Arboite, M., Álvarez-Ciara, A., Corrales, N., Verdelus, J., Dietrich, W. D., Keane, R. W., Vaccari, J. P. D. R., & Prasad, A. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122102 · Cited by 17

The Interplay between Cannabinoid Receptors and Microglia in the Pathophysiology of Alzheimer’s Disease

Ferrisi, R., Gado, F., Ricardi, C., Polini, B., Manera, C., & Chiellini, G. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12237201 · Cited by 16

Neuroprotective arylpiperazine dopaminergic/serotonergic ligands suppress experimental autoimmune encephalomyelitis in rats

Popovic, M., Stanojević, Ž., Tasić, J., Isaković, A., Paunović, V., Petricevic, S. M., Martinović, T., Ćirić, D., Kravic‐Stevovic, T., Šoškić, V., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13198 · Cited by 16

Innate immune response in astrocytes infected with herpes simplex virus 1

Bansode, Y. D., Chattopadhyay, D., & Saha, B. (2019) · Archives of Virology · doi:10.1007/s00705-019-04197-x · Cited by 16

Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice

Tsujioka, H., & Yamashita, T. (2019) · BMC Genomics · doi:10.1186/s12864-019-5974-9 · Cited by 15

Nervous System

Miller, A. D., & Zachary, J. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35775-3.00014-x · Cited by 16

Ouabain-Na+/K+-ATPase Signaling Regulates Retinal Neuroinflammation and ROS Production Preventing Neuronal Death by an Autophagy-Dependent Mechanism Following Optic Nerve Axotomy In Vitro

Mázala-de-Oliveira, T., de Figueiredo, C. S., Corrêa, G. D. R., da Silva, M. S., Miranda, R., de Azevedo, M. A. G., Cossenza, M., dos Santos, A. A., & Giestal-de-Araujo, E. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03481-0 · Cited by 14

The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease

Napolitano, F., & Montuori, N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1568629 · Cited by 15

Characterization of the Leucocyte Immunoglobulin-like Receptor B4 (Lilrb4) Expression in Microglia

Kretzschmar, F., Piecha, R., Jahn, J., Potru, P. S., & Spittau, B. (2021) · Biology · doi:10.3390/biology10121300 · Cited by 14

D-dopachrome tautomerase drives astroglial inflammation via NF-κB signaling following spinal cord injury

Li, H., He, B., Zhang, X., Hao, H., Yang, T., Sun, C., Song, H., Wang, Y., Zhu, Z., Hu, Y., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00867-7 · Cited by 17

Modulation of HERV Expression by Four Different Encephalitic Arboviruses during Infection of Human Primary Astrocytes

de Castro, F. L., Brustolini, O. J. B., Geddes, V. E. V., de Souza, J. M., Alves‐Leon, S. V., Aguiar, R. S., & de Vasconcelos, A. T. R. (2022) · Viruses · doi:10.3390/v14112505 · Cited by 14

Immune Transcriptional Response in Head Kidney Primary Cell Cultures Isolated from the Three Most Important Species in Chilean Salmonids Aquaculture

Nualart, D. P., Dann, F., Oyarzún, R., Morera, F. J., & Vargas‐Chacoff, L. (2023) · Biology · doi:10.3390/biology12070924 · Cited by 15

Physiological and Pathophysiological Roles of Transient Receptor Potential Channels in Microglia-Related CNS Inflammatory Diseases

Shirakawa, H., & Kaneko, S. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00319 · Cited by 15

The impairment in the NLRP3-induced NO secretion renders astrocytes highly permissive to T. cruzi replication

Pacheco, A. D. O. L., Vicentini, G., Matteucci, K. C., Rosa‐Ribeiro, R., Weinlich, R., & Bortoluci, K. R. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ab1118-416rr · Cited by 16

The Potentials of Melatonin in the Prevention and Treatment of Bacterial Meningitis Disease

Zhang, D., Xu, S., Wang, Y., & Zhu, G. (2021) · Molecules · doi:10.3390/molecules26051419 · Cited by 16

Pattern Recognition Receptors in CNS Disease

Carpentier, P. A., Duncan, D. S., & Miller, S. D. (2007) · Springer eBooks · doi:10.1007/978-0-387-73894-9_7

Pattern Recognition Receptors in Brain: Emphasis on Toll Like Receptors and their Types

Krishnan, J. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815124545123010004

Role of Pattern Recognition Receptors (PRRs) in Spinal Cord Injury (SCI): A Comprehensive Review

Bayat, H., Amini, M., Ghaffari, N., Ebrahimi, B., Zarini, D., & Hassanzadeh, G. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06240-w

Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets

Baral, H., & Kaundal, R. K. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.03.001 · Cited by 15

Pattern recognition receptors as potential drug targets in inflammatory disorders

McKernan, D. P. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.09.001 · Cited by 65