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Pattern recognition receptors and central nervous system repair
Open accessAbstract
Pattern recognition receptors (PRRs) are part of the innate immune response and were originally discovered for their role in recognizing pathogens by ligating specific pathogen associated molecular patterns (PAMPs) expressed by microbes. Now the role of PRRs in sterile inflammation is also appreciated, responding to endogenous stimuli referred to as "damage associated molecular patterns" (DAMPs) instead of PAMPs. The main families of PRRs include Toll-like receptors (TLRs), Nod-like receptors (NLRs), RIG-like receptors (RLRs), AIM2-like receptors (ALRs), and C-type lectin receptors. Broad expression of these PRRs in the CNS and the release of DAMPs in and around sites of injury suggest an important role for these receptor families in mediating post-injury inflammation. Considerable data now show that PRRs are among the first responders to CNS injury and activation of these receptors on microglia, neurons, and astrocytes triggers an innate immune response in the brain and spinal cord. Here we discuss how the various PRR families are activated and can influence injury and repair processes following CNS injury.
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“As TLR3 is abundantly expressed in the brain187, abnormal activation of NMDA receptor signalling by quinolinic acid might be at least partially responsible for numerous neurological diseases186,188.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [187]
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Cites
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848
Lemaître, B., Nicolas, E., Michaut, L., Reichhart, J., & Hoffmann, J. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80172-5 · Cited by 4,224
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Research works printed but not linked: 1
- de Rivero Vaccari, 2013, Mincle signaling contributes to the inflammatory response after traumatic brain injury, J. Immunol., 190
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Clarke, P., Zhuang, Y., Berens, H. M., Leser, J. S., & Tyler, K. L. (2019) · Journal of Virology · doi:10.1128/jvi.02027-18 · Cited by 15
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Dantio, C. D., Fasoranti, D. O., Teng, C., & Li, X. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5523 · Cited by 16
Revisiting the immune landscape post spinal cord injury: More than black and white
Liu, Z.-G., Yang, F., Shi, J., Pengyu, C., Yu, S., & Bo-Yin, Z. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.963539 · Cited by 14
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Wei, C., Li, P., Liu, L., Zhang, H., Zhao, T., & Chen, Y. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.2c01334 · Cited by 14
Ning, J., Sun, K., Wang, X., Fan, X., Jia, K., Cui, J., & Ma, C. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00634-5 · Cited by 14
Vandermeulen, L., Geric, I., Fumagalli, L., Kreir, M., Lu, A., Nonneman, A., Premereur, J., Wolfs, L., Policarpo, R., Fattorelli, N., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00725-9 · Cited by 16
Balaji, P. G., Bhimrao, L. S., & Yadav, A. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04215-3 · Cited by 17
Role of NLRP3 Inflammasome in Chronic Pain and Alzheimer's Disease—A Review
Moradi, F., & Mokhtari, T. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70071 · Cited by 14
Luo, C., Chen, Q., Liu, B., Wang, S., Yu, H., Guan, X., Zhao, Y., & Wang, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9663208 · Cited by 16
Livni, L., Keating, B. A., Fiore, N. T., Lees, J. G., Goldstein, D., & Moalem‐Taylor, G. (2021) · Pain · doi:10.1097/j.pain.0000000000002384 · Cited by 13
Shukla, M., Garg, A., Dhole, T. N., & Chaturvedi, R. (2023) · Virology Journal · doi:10.1186/s12985-023-01966-8 · Cited by 15
Xiao, B., Adjei‐Sowah, E., & Benoit, D. S. W. (2023) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2023.102727 · Cited by 13
Shi, C., Lin, T.-H., & Qu, C. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109946 · Cited by 13
Zhang, H., Hu, Y., Wang, Y., Zhou, Y., Zhu, Z., Chen, M.-H., Wang, Y., Xu, H., & Wang, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.363184 · Cited by 14
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Yang, J., & Liu, C. Q. (2000) · PubMed · Cited by 13
Shakova, F. M., Kirova, Y. I., Silachev, D. N., Romanova, G. A., & Morozov, S. G. (2021) · Brain Sciences · doi:10.3390/brainsci11030325 · Cited by 13
“It is known that HIF-1α is a critical factor in the formation of gene-mediated adaptation mechanisms under conditions of oxygen deficiency, including angiogenesis, the glycolytic oxidation pathway, and erythropoiesis [85].”
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Balbi, M., Bonanno, G., Bonifacino, T., & Milanese, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065240 · Cited by 14
Jasim, M. H., Abbood, R. S., Sanghvi, G. V., Roopashree, R., Uthirapathy, S., Kashyap, A., Sabarivani, A., Ray, S., Mustafa, Y. F., & Yasin, H. A. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114537 · Cited by 13
Expression of C-type lectin receptor mRNA in chronic otitis media with cholesteatoma
Kim, S. H., Han, S. H., Byun, J. Y., Park, M. S., Kim, Y. I., & Yeo, S. G. (2017) · Acta Oto-Laryngologica · doi:10.1080/00016489.2016.1269196 · Cited by 12
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Seol, Y., Ki, S., Ryu, H. L., Chung, S., Lee, J.-H., & Ryu, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.593724 · Cited by 12
Wang, Y.-J., Downey, M. A., Choi, S., Shoup, T. M., & Elmaleh, D. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-00465-6 · Cited by 14
Dong, J., Xie, T., Shi, C., Feng, G., Zhang, H., Xu, Z., & Dong, L. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s543912 · Cited by 12
Chun, B. J., Aryal, S. P., Varughese, P., Sun, B., Bruno, J., Richards, C. I., Bachstetter, A. D., & Kekenes-Huskey, P. M. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1037417 · Cited by 12
Ismail, E. A. R., Nyandoro, V. O., Omolo, C. A., & Govender, T. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501146 · Cited by 10
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Kayhanian, S., Glynos, A., Mair, R. J., Lakatos, A., Hutchinson, P. J., Helmy, A. E., & Chinnery, P. F. (2022) · Neurotrauma Reports · doi:10.1089/neur.2022.0032 · Cited by 12
Microglial reprogramming by Hv1 antagonism protects neurons from inflammatory and glutamate toxicity
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Preissner, K. T., & Fischer, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119408 · Cited by 12
Zhang, R., Wang, J., Deng, Q., Xiao, X., Zeng, X., Lai, B., Li, G., Ma, Y., Ruan, J., Han, I., et al. (2023) · Neurospine · doi:10.14245/ns.2346824.412 · Cited by 9
Fukuda, Y., Nakajima, K., & Mutoh, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186456 · Cited by 9
Chen, J., Liu, Z., Zhou, F., Sun, Y., Jiang, Z., & Zhao, P. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1555307 · Cited by 8
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Siemsen, B., Landin, J., McFaddin, J., Hooker, K., Chandler, L., & Scofield, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/566034 · Cited by 8
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Kolpek, D., Kim, J., Mohammed, H., Gensel, J. C., & Park, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s497859 · Cited by 7
Jung, S. Y., Kim, S. S., Kim, Y. I., Chung, H., Kim, S. H., & Yeo, S. G. (2018) · Molecules · doi:10.3390/molecules23040734 · Cited by 7
Zhang, Y., Yan, Y., Smagghe, G. J., Yang, H., Dai, R., & Yang, W. (2023) · Insect Science · doi:10.1111/1744-7917.13298 · Cited by 7
Montagud‐Romero, S., Miñarro, J., & Rodríguez‐Arias, M. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_260 · Cited by 7
Kalaga, P., & Ray, S. K. (2025) · Brain Sciences · doi:10.3390/brainsci15020197 · Cited by 6
Zong, L., Chen, P., Shi, J., Chen, H., Lin, W., Ou, G., & Chen, X. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1695058 · Cited by 6
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Cossu, D., Yokoyama, K., Sakanishi, T., Sechi, L. A., & Hattori, N. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad015 · Cited by 6
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Eissa, N., Kermarrec, L., & Ghia, J. (2017) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-59749-2_13 · Cited by 5
Arulselvan, P., Choi, D., Sivaprakasam, G., Ganesan, P., Muniandy, K., Park, S., Cho, D.-Y., & Kim, J.-S. (2019) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.254604 · Cited by 5
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Satala, C.-B., Onofrei, A., Vrînceanu, O., & Mihalache, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052107 · Cited by 4
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Razavi, S. M., Hosseini, Y., Niknejad, A., Esmaealzadeh, N., Arab, Z. N., Mavaddat, H., Shahrahmani, F., Mortazavi, A., Momtaz, S., & Abdolghaffari, A. H. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03868-8 · Cited by 4
Stimmer, L., Confais, J., Jong, A. E. J. '., Veth, J., Fovet, C.-M., Horellou, P., Massonneau, J., Perrin, A., Miotello, G., Avazeri, É., et al. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00646-x · Cited by 4
Yurtdas, C., Zortul, H., Yılmaz, B., & Arıcıoğlu, F. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100462 · Cited by 6
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Toben, C. G., & Baune, B. T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00007-6 · Cited by 4
Rexach, J. E., Swarup, V., Chang, T. S., & Geschwind, D. H. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/597542 · Cited by 4
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Zhang, Y., Ai, H., Zhang, P., & Li, B. (2024) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.70012 · Cited by 3
Rajkovic, C. J., MacElroy, D., Spirollari, E., Vazquez, S. M., Subah, G., Lazzari, J. L., Zeller, S. L., Wainwright, J. V., Jhanwar‐Uniyal, M., & Kinon, M. D. (2025) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2025.104011 · Cited by 3
Xie, B., Ni, H., Yao, J., Xu, Z., Bian, S., Wang, H., Zhu, K., Wu, X., Song, P., Wu, Y., et al. (2025) · Communications Medicine · doi:10.1038/s43856-025-00909-4 · Cited by 3
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Lu, H., Zhang, Y., Chen, C., Xie, H., Li, Y., & Qiu, S. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03723-4 · Cited by 3
Widjaya, M. A., Lee, S., Cheng, W., & Wu, B. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230803 · Cited by 3
Ghosh, S., & Sarma, J. D. (2025) · Biogerontology · doi:10.1007/s10522-025-10252-9 · Cited by 3
Cartarozzi, L. P., Lima, B. H. D. M., Tomiyama, A. L. R. M., Santos, F. R., & de Oliveira, A. L. R. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578655 · Cited by 3
Malik, P., & Shroff, M. M. (2022) · Neuroradiology · doi:10.1007/s00234-022-03100-x · Cited by 3
Zhang, Y., Li, Z., Zhang, K., Chang, Y., Chen, J., Al‐Nusaif, M., Pan, S., & Huang, K. (2023) · Exploration of neuroscience · doi:10.37349/en.2023.00014 · Cited by 3
Ju, C. S., He, L., Pei, Y., Jiang, Y., Huang, R., Li, Y. M., Liao, L., Jang, S., & Wang, Y. P. (2015) · Journal of Fish Biology · doi:10.1111/jfb.12815 · Cited by 3
Infections and Inflammation in the Brain and Spinal Cord: A Dangerous Liaison
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Metadata
- Authors
- Kigerl, K. A., de Rivero Vaccari, J. P., Dietrich, W. D., Popovich, P. G., & Keane, R. W.
- Affiliations
- The Ohio State University Wexner Medical Center (US)
- University of Miami (US)
- Corresponding author
- Popovich, Phillip G.
- Keane, Robert W.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 258
- Pages
- 5-16
- ISSN
- 0014-4886 (ISSN-L)
- PMC
- PMC4974939
- OpenAlex
- W2031080649
- Cited by
- 490
- References
- 143
- Citations by year
- 2026: 26 · 2025: 44 · 2024: 44 · 2023: 50 · 2022: 59 · 2021: 50 · 2020: 50 · 2019: 38 · 2018: 38 · 2017: 38 · 2016: 15 · 2015: 31 · 2014: 6
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-043246, R01NS042133, NS059836, R01NS059836, R01NS043246)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- pattern recognition receptors, central nervous system injury, neuroinflammation, damage-associated molecular patterns, pathogen-associated molecular patterns, Toll-like receptors, NOD-like receptors, RIG-I-like receptors, AIM2-like receptors, C-type lectin receptors, microglia, astrocytes, neurons, CNS repair, innate immunity
- MeSH terms
- Animals, Cell Survival, Central Nervous System Diseases, Humans, Immunity, Innate, Signal Transduction, Receptors, Pattern Recognition, Toll-Like Receptors
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