Cited by 188Seaweed-derived Bioactive CompoundsPhytochemicals and Antioxidant ActivitiesCancer and biochemical research

Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro

Yuan, Yvonne V., Carrington, Meshell F., Walsh, Natalie A.·2005·Food and Chemical Toxicology

Published version of a preprint

Abstract

Previously, we reported that a 1-butanol soluble extract of the edible red alga Palmaria palmata, known as dulse, exhibited hydroxyl and stable free radical scavenging activity as well as inhibition of lipid peroxidation, attributed to the reducing activity and polyphenol content of the dulse extract. In the present study, we evaluated the antioxidant and antiproliferative activities of two grades of dulse harvested from Canadian Maritime locations differing in UV radiation exposure (i.e. west versus east coasts of Grand Manan Island, New Brunswick). The 1-butanol soluble extract from Grade 1 dulse (reduced UV-exposure) exhibited lower reducing activity versus Grade 2 dulse (greater UV exposure) reflecting a lower requirement for endogenous antioxidant protection. Grade 1 and 2 dulse extracts both inhibited (p0.03) AAPH-induced lipid peroxidation, but had no effect on AMVN-induced lipid peroxidation, demonstrating the aqueous nature of the antioxidants involved. The Grade 1 and 2 dulse extract inhibition (p<0.05) of HeLa cell proliferation was dose-dependent over 0.5-5.0mg/mL and maximal at 48 and 72h incubation. The antiproliferative effects of the Grade 1 and 2 dulse extracts in the present study likely reflect the bioactivity of the polyphenol content of these extracts.

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Crossref · 10.1016/j.fct.2005.02.012

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  • Palmaria palmata is rich in polyphenols.

    “Palmaria palmata, an edible seaweed, is rich in polyphenols with potential antioxidant and anticancer properties [161,162,163].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [163]

  • Polyphenols from Palmaria palmata have potential antioxidant properties.

    “Palmaria palmata, an edible seaweed, is rich in polyphenols with potential antioxidant and anticancer properties [161,162,163].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [163]

  • Polyphenols from Palmaria palmata have potential anticancer properties.

    “Palmaria palmata, an edible seaweed, is rich in polyphenols with potential antioxidant and anticancer properties [161,162,163].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [163]

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Authors
Yuan, Y. V., Carrington, M. F., & Walsh, N. A.
Affiliations
Toronto Metropolitan University (CA)
Corresponding author
Yuan, Yvonne V.
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2005-07
Volume
43
Issue
7
Pages
1073-1081
ISSN
0278-6915 (ISSN-L)
OpenAlex
W2030468710
Cited by
188
References
50
Citations by year
2026: 2 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 15 · 2016: 8 · 2015: 16 · 2014: 8 · 2013: 17 · 2012: 10
FWCI
3.51
Type
journal article
Language
en
Open access
closed
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Natural Sciences and Engineering Research Council of Canada
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
dulse, Palmaria palmata, red algae, antioxidant activity, antiproliferative activity, UV exposure, lipid peroxidation inhibition, free radical scavenging, polyphenols, reducing activity, HeLa cells, Grand Manan Island
MeSH terms
Rhodophyta, Antioxidants, Dose-Response Relationship, Drug, Emulsions, Flavonoids, HeLa Cells, Humans, Oxidation-Reduction, Phenols, Lipid Peroxidation, Thiobarbituric Acid Reactive Substances, Linoleic Acid, Cell Proliferation, Polyphenols

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