Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro
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Abstract
Previously, we reported that a 1-butanol soluble extract of the edible red alga Palmaria palmata, known as dulse, exhibited hydroxyl and stable free radical scavenging activity as well as inhibition of lipid peroxidation, attributed to the reducing activity and polyphenol content of the dulse extract. In the present study, we evaluated the antioxidant and antiproliferative activities of two grades of dulse harvested from Canadian Maritime locations differing in UV radiation exposure (i.e. west versus east coasts of Grand Manan Island, New Brunswick). The 1-butanol soluble extract from Grade 1 dulse (reduced UV-exposure) exhibited lower reducing activity versus Grade 2 dulse (greater UV exposure) reflecting a lower requirement for endogenous antioxidant protection. Grade 1 and 2 dulse extracts both inhibited (p0.03) AAPH-induced lipid peroxidation, but had no effect on AMVN-induced lipid peroxidation, demonstrating the aqueous nature of the antioxidants involved. The Grade 1 and 2 dulse extract inhibition (p<0.05) of HeLa cell proliferation was dose-dependent over 0.5-5.0mg/mL and maximal at 48 and 72h incubation. The antiproliferative effects of the Grade 1 and 2 dulse extracts in the present study likely reflect the bioactivity of the polyphenol content of these extracts.
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Palmaria palmata is rich in polyphenols.
“Palmaria palmata, an edible seaweed, is rich in polyphenols with potential antioxidant and anticancer properties [161,162,163].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [163]
Polyphenols from Palmaria palmata have potential antioxidant properties.
“Palmaria palmata, an edible seaweed, is rich in polyphenols with potential antioxidant and anticancer properties [161,162,163].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [163]
Polyphenols from Palmaria palmata have potential anticancer properties.
“Palmaria palmata, an edible seaweed, is rich in polyphenols with potential antioxidant and anticancer properties [161,162,163].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [163]
Cites
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works
Antioxidant Activity of Various Tea Extracts in Relation to Their Antimutagenicity
Yen, G., & Chen, H.-Y. (1995) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00049a007 · Cited by 2,634 · see citing works
Screening of Plant Extracts for Antioxidant Activity: a Comparative Study on Three Testing Methods
Koleva, I. I., van Beek, T. A., Linssen, J. P. H., de Groot, C. P. G. M., & Evstatieva, L. N. (2002) · Phytochemical Analysis · doi:10.1002/pca.611 · Cited by 1,785 · see citing works
Chia seeds as a source of natural lipid antioxidants
Taga, M. S., Miller, E. E., & Pratt, D. E. (1984) · Journal of the American Oil Chemists Society · doi:10.1007/bf02542169 · Cited by 1,049 · see citing works
Estimates of the world‐wide prevalence of cancer for 25 sites in the adult population
Pisani, P., Bray, F., & Parkin, D. M. (2001) · International Journal of Cancer · doi:10.1002/ijc.1571 · Cited by 722 · see citing works
Natural antioxidants : chemistry, health effects, and applications
Shahidi, F. (1997) · Cited by 677 · see citing works
Seaweed in food products: biochemical and nutritional aspects
Mabeau, S., & Fleurence, J. (1993) · Trends in Food Science & Technology · doi:10.1016/0924-2244(93)90091-n · Cited by 622 · see citing works
[3] Free radical initiators as source of water- or lipid-soluble peroxyl radicals
Niki, E. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86095-d · Cited by 569 · see citing works
Fucoxanthin as the Major Antioxidant inHijikia fusiformis, a Common Edible Seaweed
Xiaojun, Y. A. N., Chuda, Y., SUZUKI, M., & Nagata, T. (1999) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.63.605 · Cited by 475 · see citing works
Antioxidant activity of dulse (Palmaria palmata) extract evaluated in vitro
Yuan, Y., Bone, D. E., & Carrington, M. F. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2004.04.039 · Cited by 423 · see citing works
Self-citationAntioxidant activity of fresh and processed edible seaweeds
Jiménez‐Escrig, A., Jiménez‐Jiménez, I., Pulido, R., & Saura-Calixto, F. D. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.842 · Cited by 417 · see citing works
Antioxidant and Prooxidant Actions of Prenylated and Nonprenylated Chalcones and Flavanones in Vitro
Miranda, C. L., Stevens, J. F., Ivanov, V. O., McCall, M. R., Frei, B. B., Deinzer, M. L., & Buhler, D. R. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0002995 · Cited by 355 · see citing works
Telomerase Inhibition, Telomere Shortening, and Senescence of Cancer Cells by Tea Catechins
Naasani, I., Seimiya, H., & Tsuruo, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9075 · Cited by 238 · see citing works
Review of chemical constituents of the red algaPalmaria palmata (dulse)
Morgan, K. C., Wright, J. L. C., & Simpson, F. J. (1980) · Economic Botany · doi:10.1007/bf02859553 · Cited by 201 · see citing works
Chan, J. C.-C., Cheung, P. C. K., & Ang, P. O. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9701749 · Cited by 193 · see citing works
Antioxidative activities in some common seaweeds
Yan, X., Nagata, T., & Xiao, F. (1998) · Plant Foods for Human Nutrition · doi:10.1023/a:1008007014659 · Cited by 190 · see citing works
Aguilera, J. M., Bischof, K., Karsten, U., Hanelt, D., & Wiencke, C. (2002) · Marine Biology · doi:10.1007/s00227-002-0792-y · Cited by 181 · see citing works
Shi, H., Noguchi, N., & Niki, E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00053-2 · Cited by 180 · see citing works
Galland-Irmouli, A.-V., Pons, L., Luçon, M., Villaume, C., Mrabet, N. T., Guéant, J. L., & Fleurence, J. (2000) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(99)00433-8 · Cited by 178 · see citing works
Tutour, B. L., Benslimane, F., Gouleau, M., Gouygou, J., Saadan, B., & Quéméneur, F. (1998) · Journal of Applied Phycology · doi:10.1023/a:1008007313731 · Cited by 138 · see citing works
Antioxidant metabolism in the intertidal red seaweed Stictosiphonia arbuscula following desiccation
Burritt, D. J., Larkindale, J., & Hurd, C. L. (2002) · Planta · doi:10.1007/s00425-002-0805-6 · Cited by 137 · see citing works
Aguilera, J. M., Dummermuth, A., Karsten, U., Schriek, R., & Wiencke, C. (2002) · Polar Biology · doi:10.1007/s00300-002-0362-2 · Cited by 125 · see citing works
Karsten, U., & Wiencke, C. (1999) · Journal of Plant Physiology · doi:10.1016/s0176-1617(99)80124-2 · Cited by 117 · see citing works
Bergé, J. P., Débiton, E., Dumay, J., Durand, P., & Barthomeuf, C. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020290y · Cited by 115 · see citing works
Distribution of catechins in Japanese seaweeds
Yoshie, Y., Wang, W., Petillo, D., & Suzuki, T. (2000) · Fisheries Science · doi:10.1046/j.1444-2906.2000.00160.x · Cited by 114 · see citing works
Takano, S., Nakanishi, A., Uemura, D., & Hiratå, Y. (1979) · Chemistry Letters · doi:10.1246/cl.1979.419 · Cited by 103 · see citing works
Antioxidative activities of algal extracts, synergistic effect with vitamin E
Tutour, B. L. (1990) · Phytochemistry · doi:10.1016/0031-9422(90)85327-c · Cited by 99 · see citing works
History and characteristics of Okinawan longevity food
Sho, H. (2001) · Asia Pacific Journal of Clinical Nutrition · doi:10.1111/j.1440-6047.2001.00235.x · Cited by 97 · see citing works
Hiqashi-Okaj, K., Otani, S., & Okai, Y. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00047-6 · Cited by 83 · see citing works
YAMAMOTO, I., & Maruyama, H. (1985) · Cancer Letters · doi:10.1016/0304-3835(85)90047-3 · Cited by 82 · see citing works
YAMAMOTO, I., Maruyama, H., & Moriguchi, M. (1987) · Cancer Letters · doi:10.1016/0304-3835(87)90033-4 · Cited by 80 · see citing works
Action of DCFH and BODIPY as a Probe for Radical Oxidation in Hydrophilic and Lipophilic Domain
Yoshida, Y., Shimakawa, S., Itoh, N., & Niki, E. (2003) · Free Radical Research · doi:10.1080/1071576031000148736 · Cited by 78 · see citing works
Antioxidant effect of the constituents of susabinori (Porphyra yezoensis)
Nakayama, R., Tamura, Y., Kikuzaki, H., & Nakatani, N. (1999) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-999-0017-3 · Cited by 78 · see citing works
Okai, Y., Higashi‐Okai, K., Yano, Y., & Otani, S. (1996) · Cancer Letters · doi:10.1016/0304-3835(95)04101-x · Cited by 75 · see citing works
Skibola, C. F. (2004) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-4-10 · Cited by 70 · see citing works
Anggadiredja, Andyani, Hayati, et al. (1997) · Journal of Applied Phycology · doi:10.1023/a:1008075625735 · Cited by 68 · see citing works
Telomerase inhibition by sulfoquinovosyldiacylglycerol from edible purple laver (Porphyra yezoensis)
Eitsuka, T., Nakagawa, K., Igarashi, M., & Miyazawa, T. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.03.019 · Cited by 64 · see citing works
Droplet composition affects the rate of oxidation of emulsified ethyl linoleate
Coupland, J. N., Zhu, Z., Wan, H., et al. (1996) · Journal of the American Oil Chemists Society · doi:10.1007/bf02517957 · Cited by 52 · see citing works
YAMAMOTO, I., Maruyama, H., Takahashi, M., & Komiyama, K. (1986) · Cancer Letters · doi:10.1016/0304-3835(86)90080-7 · Cited by 51 · see citing works
Lahaye, M., Michel, C., & Barry, J. L. (1993) · Food Chemistry · doi:10.1016/0308-8146(93)90298-t · Cited by 49 · see citing works
The consumption of seaweed as a protective factor in the etiology of breast cancer
Teas, J. (1981) · Medical Hypotheses · doi:10.1016/0306-9877(81)90004-9 · Cited by 43 · see citing works
Natural Antioxidants from Oilseeds
Shahidi, F. (1997) · Springer eBooks · doi:10.1007/978-4-431-67017-9_59 · Cited by 40 · see citing works
Nagata, C., Shimizu, H., Takami, R., Hayashi, M., Takeda, N., & Yasuda, K. (2003) · Preventive Medicine · doi:10.1016/s0091-7435(03)00052-5 · Cited by 38 · see citing works
Maruyama, H., Watanabe, K., & YAMAMOTO, I. (1991) · Nutrition and Cancer · doi:10.1080/01635589109514130 · Cited by 29 · see citing works
A Novel Antioxidant Derived from Seaweed
Dunlap, W. C., Masaki, K., Yamamoto, Y., Larsen, R. M., & Karube, I. (1998) · Springer eBooks · doi:10.1007/978-1-4757-5983-9_7 · Cited by 28 · see citing works
Cutter, H., Wu, L., Kim, C., et al. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00631-5 · Cited by 26 · see citing works
Antimutagenic and Cancer Cell Growth Inhibitory Effects of Seaweeds
Cho, E. J., Rhee, S., & Park, K. (1997) · Preventive Nutrition and Food Science · Cited by 23 · see citing works
Sekikawa, I., Kubota, C., Hiraoki, T., & 辻野, 勇. (1986) · Cited by 18 · see citing works
Physical Characteristics and Antioxidative Capacity of Major Seaweeds
Han, K., Lee, E., & Sung, M. (1999) · Preventive Nutrition and Food Science · Cited by 11 · see citing works
Reddy, B. S., Numoto, S., & Choi, C. (1985) · Nutrition and Cancer · doi:10.1080/01635588509513840 · Cited by 10 · see citing works
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Marine Natural Products: A Source of Novel Anticancer Drugs
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works
Nwosu, F., Morris, J., Lund, V. A., Stewart, D., Ross, H. A., & McDougall, G. J. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2010.11.111 · Cited by 306 · see citing works
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Cornish, M. L., & Garbary, D. J. (2010) · ALGAE · doi:10.4490/algae.2010.25.4.155 · Cited by 290 · see citing works
Sivagnanam, S., Yin, S., Choi, J., Park, Y., Woo, H., & Chun, B. (2015) · Marine Drugs · doi:10.3390/md13063422 · Cited by 168 · see citing works
McLaughlin, C. M., Harnedy-Rothwell, P. A., Lafferty, R. A., Sharkey, S., Parthsarathy, V., Allsopp, P. J., McSorley, E. M., FitzGerald, R. J., & O’Harte, F. P. M. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02583-3 · Cited by 45 · see citing works
- Authors
- Yuan, Y. V., Carrington, M. F., & Walsh, N. A.
- Affiliations
- Toronto Metropolitan University (CA)
- Corresponding author
- Yuan, Yvonne V.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 43
- Issue
- 7
- Pages
- 1073-1081
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2030468710
- Cited by
- 188
- References
- 50
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 15 · 2016: 8 · 2015: 16 · 2014: 8 · 2013: 17 · 2012: 10
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- dulse, Palmaria palmata, red algae, antioxidant activity, antiproliferative activity, UV exposure, lipid peroxidation inhibition, free radical scavenging, polyphenols, reducing activity, HeLa cells, Grand Manan Island
- MeSH terms
- Rhodophyta, Antioxidants, Dose-Response Relationship, Drug, Emulsions, Flavonoids, HeLa Cells, Humans, Oxidation-Reduction, Phenols, Lipid Peroxidation, Thiobarbituric Acid Reactive Substances, Linoleic Acid, Cell Proliferation, Polyphenols
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