Biological properties of fucoxanthin in oil recovered from two brown seaweeds using supercritical CO2 extraction
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The bioactive materials in brown seaweeds hold great interest for developing new drugs and healthy foods. The oil content in brown seaweeds (Saccharina japonica and Sargassum horneri) was extracted by using environmentally friendly supercritical CO2 (SC-CO2) with ethanol as a co-solvent in a semi-batch flow extraction process and compared the results with a conventional extraction process using hexane, ethanol, and acetone mixed with methanol (1:1, v/v). The SC-CO2 method was used at a temperature of 45 °C and pressure of 250 bar. The flow rate of CO2 (27 g/min) was constant for the entire extraction period of 2 h. The obtained oil from the brown seaweeds was analyzed to determine their valuable compounds such as fatty acids, phenolic compounds, fucoxanthin and biological properties including antioxidant, antimicrobial, and antihypertension effects. The amounts of fucoxanthin extracted from the SC-CO2 oils of S. japonica and S. horneri were 0.41 ± 0.05 and 0.77 ± 0.07 mg/g, respectively. High antihypertensive activity was detected when using mixed acetone and methanol, whereas the phenolic content and antioxidant property were higher in the oil extracted by SC-CO2. The acetone-methanol mix extracts exhibited better antimicrobial activities than those obtained by other means. Thus, the SC-CO2 extraction process appears to be a good method for obtaining valuable compounds from both brown seaweeds, and showed stronger biological activity than that obtained by the conventional extraction process.
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Extraction efficiency of phenolic compounds and carotenoids increased when EtOH is used as co-solvent compared to SC-CO2 without co-solvent.
“The extraction efficiency of phenolic compounds and carotenoids increased when EtOH is used as co-solvent when compared to the use of SC-CO2 without co-solvent [21,22].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [22]
Carotenoids are natural antioxidants applied in food products; the most abundant carotenoid of marine macroalgae is fucoxanthin, which possesses antiproliferative activity; carotenoids also possess antioxidant, antimicrobial, and antihypertensive activity.
“Carotenoids are natural antioxidants and they are applied in different food products [18]. The most abundant carotenoid of marine macroalgae is fucoxanthin (Figure 4) and it possess antiproliferative activity [19,20]. Except for antiproliferative properties, carotenoids also possess antioxidant [21], antimicrobial, and antihypertensive activity [22].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [22]
SC-CO2 was used mostly for extraction of polyphenols and carotenoids at pressures mostly 20-30 MPa and temperatures 40-60 °C, with some authors using ethanol as co-solvent.
“SC-CO2 was used mostly for the extraction of polyphenols and carotenoids where applied pressures were at range mostly of 20–30 MPa and some of the authors used ethanol (EtOH) as co-solvent [21,22,37,38], whereas, temperature was applied in the range 40–60 °C.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [22]
Seaweed lipids, especially ω-3 polyunsaturated fatty acids, exhibit several advantages for human health, such as prevention of cardiovascular diseases, diabetes, hypertension, autoimmune diseases, and arterosclerosis.
“Seaweed lipids, especially ω-3 polyunsaturated fatty acids, exhibit several advantages for human health, such as the prevention of cardiovascular diseases, diabetes, hypertension and autoimmune diseases, and even for the prevention of arterosclerosis [22].”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [22]
Extracts of S. japonica and S. horneri obtained with SC-CO2 and ethanol as co-solvent showed significant antioxidant activity, good antimicrobial activity against several bacteria and fungi, and moderate antihypertensive activity.
“Sivangnanam et al. [22] obtained the extracts of S. japonica and S. horneri with SC-CO2 with ethanol as co-solvent, which showed significant antioxidant activity.”
From Overview on the Application of Modern Methods for the Extraction of Bioactive Compounds from Marine Macroalgae (2018) · cites this paper as [22]
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- Authors
- Sivagnanam, S., Yin, S., Choi, J., Park, Y., Woo, H., & Chun, B.
- Affiliations
- Department of Food Science and Technology, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 608-737, Korea
- Pukyong National University (KR)
- Corresponding author
- Chun, Byung
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2015-05-29
- Volume
- 13
- Issue
- 6
- Pages
- 3422-3442
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC4483637
- OpenAlex
- W1590661664
- Cited by
- 168
- References
- 55
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 20 · 2023: 17 · 2022: 26 · 2021: 23 · 2020: 14 · 2019: 15 · 2018: 15 · 2017: 8 · 2016: 9 · 2015: 1
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- This work was supported by Ministry of Oceans and Fisheries, Republic of Korea.
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- fucoxanthin, brown algae, Laminaria japonica, Sargassum horneri, supercritical CO2 extraction, fatty acids, phenolic compounds, antioxidant activity, antimicrobial activity, antihypertensive effect, green extraction
- MeSH terms
- Anti-Infective Agents, Antihypertensive Agents, Antioxidants, Carbon Dioxide, Fatty Acids, Laminaria, Phenols, Plant Oils, Solvents, Temperature, Xanthophylls, Sargassum
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