Cited by 114Essential Oils and Antimicrobial ActivityNatural Compounds in Disease TreatmentSesquiterpenes and Asteraceae Studies

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Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

Yoon, W.J., Moon, J.Y., Song, G., Lee, Y.K., Han, M.S., Lee, J.S., Ihm, B.S., Lee, W.J., Lee, N.H., Hyun, C.G.·2010·Food and Chemical Toxicology

DOI 10.1016/j.fct.2010.02.014

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Abstract

In the present study, the chemical constituents of Artemisia fukudo essential oil (AFE) were investigated using GC-MS. The major constituents were alpha-thujone (48.28%), beta-thujone (12.69%), camphor (6.95%) and caryophyllene (6.01%). We also examined the effects of AFE on the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6, in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Western blotting and RT-PCR tests indicated that AFE has potent dose-dependent inhibitory effects on pro-inflammatory cytokines and mediators. We investigated the mechanism by which AFE inhibits NO and PGE(2) by examining the level of nuclear factor-kappaB (NF-kappaB) activation within the mitogen-activated protein kinase (MAPK) pathway, which is an inflammation-induced signal pathway in RAW 264.7 cells. AFE inhibited LPS-induced ERK, JNK, and p38 phosphorylation. Furthermore, AFE inhibited the LPS-induced phosphorylation and degradation of Ikappa-B-alpha, which is required for the nuclear translocations of the p50 and p65 NF-kappaB subunits in RAW 264.7 cells. Our results suggest that AFE might exert an anti-inflammatory effect by inhibiting the expression of pro-inflammatory cytokines. Such an effect is mediated by a blocking of NF-kappaB activation which consequently inhibits the generation of inflammatory mediators in RAW264.7 cells. AFE may be useful for treating inflammatory diseases.

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Original article: HYPOCHOERIS RADICATA ATTENUATES LPS-INDUCED INFLAMMATION BY SUPPRESSING P38, ERK, AND JNK PHOSPHORYLATION IN RAW 264.7 MACROPHAGES
Kim, M., Kim, S., Kim, S. S., Lee, N. H., & Hyun, C. (2014)
Abstracts from the 16th Biennial Conference of APSA
(2017) · Animal Production Science · doi:10.1071/anv57n12abs

Authors: Yoon, W. J., Moon, J. Y., Song, G., Lee, Y. K., Han, M. S., Lee, J. S., Ihm, B. S., Lee, W. J., Lee, N. H., & Hyun, C. G.
Affiliations: Mokpo National University (KR)
Jeju National University (KR)
Corresponding author: Hyun, C.G.
ORCID: Yoon, W.J.
Moon, J.Y.
Song, G.
Venue: Food and Chemical Toxicology
Publisher: Elsevier BV
Published: 2010-05
Volume: 48
Issue: 5
Pages: 1222-1229
ISSN: 0278-6915 (ISSN-L)
DOI: 10.1016/j.fct.2010.02.014
OpenAlex: W2048551183
Cited by: 114
References: 35
Citations by year: 2026: 7 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 16 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 7
FWCI: 11.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Food and Chemical Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Keywords: essential oils, anti-inflammatory activity, lipopolysaccharide-induced inflammation, RAW 264.7 macrophages, NF-κB signaling, MAPK signaling, α-thujone, β-thujone, camphor, caryophyllene, nitric oxide, prostaglandin E2, inflammatory cytokines, IκBα phosphorylation, ERK, JNK, p38 MAPK
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Cell Survival, Macrophages, Gas Chromatography-Mass Spectrometry, Oils, Volatile, Plant Oils, RNA, Messenger, Down-Regulation, Gene Expression, Cytokines, NF-kappa B, Inflammation Mediators, Artemisia, Gene Expression Profiling, Mitogen-Activated Protein Kinases, Cell Proliferation, Mice

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Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

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