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Cited by 114Essential Oils and Antimicrobial ActivityNatural Compounds in Disease TreatmentSesquiterpenes and Asteraceae Studies

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages

Yoon, W.J., Moon, J.Y., Song, G., Lee, Y.K., Han, M.S., Lee, J.S., Ihm, B.S., Lee, W.J., Lee, N.H., Hyun, C.G.·2010·Food and Chemical Toxicology
DOI 10.1016/j.fct.2010.02.014
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Abstract

In the present study, the chemical constituents of Artemisia fukudo essential oil (AFE) were investigated using GC-MS. The major constituents were alpha-thujone (48.28%), beta-thujone (12.69%), camphor (6.95%) and caryophyllene (6.01%). We also examined the effects of AFE on the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6, in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Western blotting and RT-PCR tests indicated that AFE has potent dose-dependent inhibitory effects on pro-inflammatory cytokines and mediators. We investigated the mechanism by which AFE inhibits NO and PGE(2) by examining the level of nuclear factor-kappaB (NF-kappaB) activation within the mitogen-activated protein kinase (MAPK) pathway, which is an inflammation-induced signal pathway in RAW 264.7 cells. AFE inhibited LPS-induced ERK, JNK, and p38 phosphorylation. Furthermore, AFE inhibited the LPS-induced phosphorylation and degradation of Ikappa-B-alpha, which is required for the nuclear translocations of the p50 and p65 NF-kappaB subunits in RAW 264.7 cells. Our results suggest that AFE might exert an anti-inflammatory effect by inhibiting the expression of pro-inflammatory cytokines. Such an effect is mediated by a blocking of NF-kappaB activation which consequently inhibits the generation of inflammatory mediators in RAW264.7 cells. AFE may be useful for treating inflammatory diseases.

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Crossref · 10.1016/j.fct.2010.02.014

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  1. Matsuo, 1973, Chemical constituents of the essential oil of Artemisia fukudo, Flavour Indust., 4, 343

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Metadata

Authors
Yoon, W. J., Moon, J. Y., Song, G., Lee, Y. K., Han, M. S., Lee, J. S., Ihm, B. S., Lee, W. J., Lee, N. H., & Hyun, C. G.
Affiliations
  • Mokpo National University (KR)
  • Jeju National University (KR)
Corresponding author
Hyun, C.G.
ORCID
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2010-05
Volume
48
Issue
5
Pages
1222-1229
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2010.02.014
OpenAlex
W2048551183
Cited by
114
References
35
Citations by year
2026: 7 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 16 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 7
FWCI
11.27
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
  • Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Keywords
essential oils, anti-inflammatory activity, lipopolysaccharide-induced inflammation, RAW 264.7 macrophages, NF-κB signaling, MAPK signaling, α-thujone, β-thujone, camphor, caryophyllene, nitric oxide, prostaglandin E2, inflammatory cytokines, IκBα phosphorylation, ERK, JNK, p38 MAPK
MeSH terms
Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Cell Survival, Macrophages, Gas Chromatography-Mass Spectrometry, Oils, Volatile, Plant Oils, RNA, Messenger, Down-Regulation, Gene Expression, Cytokines, NF-kappa B, Inflammation Mediators, Artemisia, Gene Expression Profiling, Mitogen-Activated Protein Kinases, Cell Proliferation, Mice

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