The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages
Abstract
In the present study, the chemical constituents of Artemisia fukudo essential oil (AFE) were investigated using GC-MS. The major constituents were alpha-thujone (48.28%), beta-thujone (12.69%), camphor (6.95%) and caryophyllene (6.01%). We also examined the effects of AFE on the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6, in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Western blotting and RT-PCR tests indicated that AFE has potent dose-dependent inhibitory effects on pro-inflammatory cytokines and mediators. We investigated the mechanism by which AFE inhibits NO and PGE(2) by examining the level of nuclear factor-kappaB (NF-kappaB) activation within the mitogen-activated protein kinase (MAPK) pathway, which is an inflammation-induced signal pathway in RAW 264.7 cells. AFE inhibited LPS-induced ERK, JNK, and p38 phosphorylation. Furthermore, AFE inhibited the LPS-induced phosphorylation and degradation of Ikappa-B-alpha, which is required for the nuclear translocations of the p50 and p65 NF-kappaB subunits in RAW 264.7 cells. Our results suggest that AFE might exert an anti-inflammatory effect by inhibiting the expression of pro-inflammatory cytokines. Such an effect is mediated by a blocking of NF-kappaB activation which consequently inhibits the generation of inflammatory mediators in RAW264.7 cells. AFE may be useful for treating inflammatory diseases.
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In the citing paper
“α-Thujone, β-thujone, camphor, and caryophyllene were the main components of Artemisia fukudo oil that were able to inhibit the release of TNF-α, IL-1β, and IL-6 in LPS-treated RAW 264.7 cells [116].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [116]
In the citing paper
“iNOS catalises the production of large amount of NO from L-arginine and molecular oxygen, is mainly triggered and regulated by a series of signalling pathways including nuclear factor-κB (NF-κB) transcription factor and mitogen-activated protein kinases (MAPKs) [116].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [116]
In the citing paper
“The inhibitory effect of some of the essential oils on the production of pro-inflammatory cytokines reported in this chapter seems to be mediated by suppressing gene expression of these cytokines. Such was described by some authors because they found that the essential oils studied significantly suppressed the protein and mRNA expression of the cytokines in stimulated cells, assuming therefore,”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [116]
In the citing paper
“Artemisia fukudo Makino essential oil, mainly constituted by α-thujone, β-thujone, camphor, and caryophyllene attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages. The essential oil in LPS-induced inflammation act through the reduction of IκBα phosphorilation and blockage of NF-κB and translocation of p50 and p65 units to the nucleus. The same oil”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [116]
Citations
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Research works printed but not linked: 1
- Matsuo, 1973, Chemical constituents of the essential oil of Artemisia fukudo, Flavour Indust., 4, 343
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Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933
The Artemisia L. Genus: A Review of Bioactive Essential Oils
Abad, M. J., Bedoya, L. M., Ticona, L. A., & Bermejo, P. (2012) · Molecules · doi:10.3390/molecules17032542 · Cited by 620
Ehrnhöfer-Ressler, M. M., Fricke, K., Pignitter, M., Walker, J. M., Walker, J., Rychlik, M., & Somoza, V. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf305472t · Cited by 139
Bioactive Compounds and Health Benefits of Artemisia Species
Nigam, M., Atanassova, M., Mishra, A. P., Pezzani, R., Devkota, H. P., Plygun, S., Salehi, B., Setzer, W. N., & Sharifi‐Rad, J. (2019) · Natural Product Communications · doi:10.1177/1934578x19850354 · Cited by 145
Kim, K., Ko, Y.-J., Yang, H.-M., Ham, Y., Roh, S. W., Jeon, Y., Ahn, G., Kang, M., Yoon, W., Kim, D., et al. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.03.017 · Cited by 129
Metadata
- Authors
- Yoon, W. J., Moon, J. Y., Song, G., Lee, Y. K., Han, M. S., Lee, J. S., Ihm, B. S., Lee, W. J., Lee, N. H., & Hyun, C. G.
- Affiliations
- Mokpo National University (KR)
- Jeju National University (KR)
- Corresponding author
- Hyun, C.G.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 48
- Issue
- 5
- Pages
- 1222-1229
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2048551183
- Cited by
- 114
- References
- 35
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 16 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 7
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Keywords
- essential oils, anti-inflammatory activity, lipopolysaccharide-induced inflammation, RAW 264.7 macrophages, NF-κB signaling, MAPK signaling, α-thujone, β-thujone, camphor, caryophyllene, nitric oxide, prostaglandin E2, inflammatory cytokines, IκBα phosphorylation, ERK, JNK, p38 MAPK
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Cell Survival, Macrophages, Gas Chromatography-Mass Spectrometry, Oils, Volatile, Plant Oils, RNA, Messenger, Down-Regulation, Gene Expression, Cytokines, NF-kappa B, Inflammation Mediators, Artemisia, Gene Expression Profiling, Mitogen-Activated Protein Kinases, Cell Proliferation, Mice
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