Structural analysis of a fucoidan from the brown alga Fucus evanescens by MALDI-TOF and tandem ESI mass spectrometry
Abstract
A fucoidan, a heterogeneous sulfated polysaccharide from the brown alga Fucus evanescens, was depolymerized under solvolytic conditions, and its ethanol-extracted low-molecular-weight fraction was analyzed by MALDI-TOFMS and ESIMS/MS. It was found that the mixture contained unsulfated oligosaccharides including some monosulfated components, which were shown to consist of mainly (1-->3)-linked 2-O-sulfonated fucose residues (from 1 to 4). Minor components of the mixture were shown to contain 2-O- and 4-O-sulfonated xylose and galactose residues. Among them, mixed monosulfonated fucooligosaccharides were detected and characterized: Xyl-(1-->4)-Fuc, Gal-(1-->4)-Fuc, Gal-(1-->4)-Gal-(1-->4)-Fuc, Gal-(1-->4)-Gal. Fucose, galactose, and xylose residues were shown to be mainly 2-O-sulfonated with traces of 4-O-sulfonation. Glucuronic acid was also found as a part of non-sulfated fucooligosaccharides: Fuc-(1-->3)-GlcA, Fuc-(1-->4)-Fuc-(1-->3)-GlcA, Fuc-(1-->3)-Fuc-(1-->4)-Fuc-(1-->3)-GlcA.
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Glucuronic acid was detected as being a part of the non-sulfated fucooligosaccharides: Fuc-(1→3)-GlcA, Fuc-(1→4)-Fuc-(1→3)-GlcA, Fuc-(1→3)-Fuc-(1→3)-GlcA.
“Glucuronic acid (GlcA) was also detected as being a part of the non-sulfated fucooligosaccharides: Fuc-(1→3)-GlcA, Fuc-(1→4)-Fuc-(1→3)-GlcA, Fuc-(1→3)-Fuc-(1→3)-GlcA respectively [33].”
Glucuronic acid has been detected and found to be an integral part of non-sulfated fucooligosaccharides in F. evanescens.
“Glucuronic acid (GlcA) has also been detected and found to be an integral part of the non-sulfated fucooligosaccharides: Fuc-(1A3)-GlcA, Fuc-(1A4)-Fuc-(1A3)-GlcA, Fuc-(1A3)-Fuc-(1A3)-GlcA respectively.13”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [13]
More detailed analysis of F. evanescens by MALDI-TOF and tandem ESI mass spectrometry revealed minor components such as mixed mono-sulfated fucooligosaccharides containing both 2-O- and 4-O-sulfated (1→4)-bonded xylose and galactose residues.
“More detailed analysis of F. evanescens by MALDI-TOF and tandem ESI mass spectrometry has also revealed the presence of minor components such as mixed mono-sulfated fucooligosaccharides containing both 2-O-and 4-O-sulfated (1A4) bonded xylose and galactose residues: Xyl-(1A4)-Fuc, Gal-(1A4)-Fuc, Gal-(1A4)-Gal-(1A4)-Fuc, Gal-(1A4)-Gal.”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [13]
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- Authors
- Anastyuk, S. D., Shevchenko, N. M., Nazarenko, E. L., Dmitrenok, P. S., & Zvyagintseva, T. N.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Anastyuk, Stanislav D.
- Venue
- Carbohydrate Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 344
- Issue
- 6
- Pages
- 779-787
- ISSN
- 0008-6215 (ISSN-L)
- OpenAlex
- W2171423770
- Cited by
- 96
- References
- 27
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 14 · 2012: 6
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Russian Foundation for Basic Research
- Far East Branch, Russian Academy of Sciences
- Russian Academy of Sciences
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- fucoidan, Fucus evanescens, sulfated polysaccharides, glucuronic acid, brown algae polysaccharides
- MeSH terms
- Phaeophyceae, Carbohydrate Sequence, Molecular Sequence Data, Polysaccharides, Molecular Structure, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Spectrometry, Mass, Electrospray Ionization, Tandem Mass Spectrometry
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