The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Epac1 regulates integrity of endothelial cell junctions through VE‐cadherin
Open accessAbstract
We have previously shown that Rap1 as well as its guanine nucleotide exchange factor Epac1 increases cell–cell junction formation. Here, we show that activation of Epac1 with the exchange protein directly activated by cAMP (Epac)‐specific cAMP analog 8CPT‐2′O‐Me‐cAMP (007) resulted in a tightening of the junctions and a decrease in the permeability of the endothelial cell monolayer. In addition, 007 treatment resulted in the breakdown of actin stress fibers and the formation of cortical actin. These effects were completely inhibited by siRNA against Epac1. In VE‐cadherin knock‐out cells Epac1 did not affect cell permeability, whereas in cells re‐expressing VE‐cadherin this effect was restored. Finally, the effect of Epac activation on the actin cytoskeleton was independent of junction formation. From these results we conclude that in human umbilical vein endothelial cells Epac1 controls VE‐cadherin‐mediated cell junction formation and induces reorganization of the actin cytoskeleton.
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A novel endothelial-specific membrane protein is a marker of cell-cell contacts.
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Self-citationA novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
Enserink, J. M., Christensen, A. E., de Rooij, J., van Triest, M., Schwede, F., Genieser, H. G., Døskeland, S. O., Blank, J. L., & Bos, J. L. (2002) · Nature Cell Biology · doi:10.1038/ncb874 · Cited by 625
Self-citationEpac: a new cAMP target and new avenues in cAMP research
Bos, J. L. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1197 · Cited by 489
Self-citationRIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion
Lafuente, E. M., van Puijenbroek, A. A. F. L., Krause, M., Carman, C. V., Freeman, G. J., Berezovskaya, A., Constantine, E., Springer, T. A., Gertler, F. B., & Boussiotis, V. A. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.021 · Cited by 420
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The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
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Gavard, J., & Gutkind, J. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1486 · Cited by 1,018
The role of adherens junctions and VE-cadherin in the control of vascular permeability
Dejana, E., Orsenigo, F., & Lampugnani, M. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.017897 · Cited by 986
Self-citationVE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity
Giannotta, M., Trani, M., & Dejana, E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.08.020 · Cited by 854
Self-citationVestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies
Claesson-Welsh, L., Dejana, E., & McDonald, D. M. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.11.006 · Cited by 631
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Metadata
- Authors
- Kooistra, M. R. H., Corada, M., Dejana, E., & Bos, J. L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-08-15
- Volume
- 579
- Issue
- 22
- Pages
- 4966-4972
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2016095963
- Cited by
- 302
- References
- 22
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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