Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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Extracellular vesicles: Exosomes, microvesicles, and friends

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Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers.

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Cell Death

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

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Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy

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Regulation of immune responses by extracellular vesicles

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Nanotubular Highways for Intercellular Organelle Transport

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Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

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Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

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Transfer of mitochondria from astrocytes to neurons after stroke

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An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

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Mitochondrial transfer between cells can rescue aerobic respiration

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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

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Mitochondrial dynamics and inheritance during cell division, development and disease

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Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

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ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA

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Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

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Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

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The internal structure of mitochondria

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Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells

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Mitochondrial Cristae: Where Beauty Meets Functionality

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Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

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The ATP synthase is involved in generating mitochondrial cristae morphology

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Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension

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Macropinocytosis: an endocytic pathway for internalising large gulps

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Extracellular vesicles round off communication in the nervous system

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Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

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Transcellular degradation of axonal mitochondria

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Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

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Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

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Pathogenic Mitochondrial DNA Mutations Are Common in the General Population

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Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

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Prevalence of mitochondrial DNA disease in adults

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Mammalian Mitochondria and Aging: An Update

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Mitochondrial gene replacement in primate offspring and embryonic stem cells

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Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy

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Familial mitochondrial encephalomyopathy (MERRF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease

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Extracellular vesicles: masters of intercellular communication and potential clinical interventions

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Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

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Structurally Distinct Membrane Nanotubes between Human Macrophages Support Long-Distance Vesicular Traffic or Surfing of Bacteria

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Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury

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Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

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Mitochondrial Inner-Membrane Fusion and Crista Maintenance Requires the Dynamin-Related GTPase Mgm1

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Flow of mitochondrial DNA across a species boundary.

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The rise of mitochondria in medicine

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Endosymbiotic theory for organelle origins

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Mitochondria Know No Boundaries: Mechanisms and Functions of Intercellular Mitochondrial Transfer

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Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy

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Towards germline gene therapy of inherited mitochondrial diseases

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Injection of isolated mitochondria during early reperfusion for cardioprotection

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Stemness in Cancer: Stem Cells, Cancer Stem Cells, and Their Microenvironment

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Mitochondrial Regulation in Pluripotent Stem Cells

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MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

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Cell-to-Cell Connection of Endothelial Progenitor Cells With Cardiac Myocytes by Nanotubes

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Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

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Mitochondrial Structure and Function Are Disrupted by Standard Isolation Methods

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Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase

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Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

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Tunneling nanotubes: A new route for the exchange of components between animal cells

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Mitochondrial involvement in psychiatric disorders

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Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

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Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e / g

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FRACTIONATION OF MAMMALIAN LIVER CELLS BY DIFFERENTIAL CENTRIFUGATION

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Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA

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Apoptosome Structure, Assembly, and Procaspase Activation

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Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis

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Internalization of isolated functional mitochondria: involvement of macropinocytosis

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An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

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Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry

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Stem cells in retinal regeneration: past, present and future

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Microvesicles and exosomes for intracardiac communication

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Strikingly Bacteria-Like and Gene-Rich Mitochondrial Genomes throughout Jakobid Protists

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Extracellular vesicles and intercellular communication within the nervous system

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Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

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Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine–induced neurotoxicity

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Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

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The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation

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Primary Mitochondrial Disease and Secondary Mitochondrial Dysfunction: Importance of Distinction for Diagnosis and Treatment

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Mitochondrial transplantation: From animal models to clinical use in humans

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Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease

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Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells

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Organ Donation after Cardiac Death

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Mitochondrial transplantation for therapeutic use

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Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

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Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids

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Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function

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Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice

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Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals

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Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming

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Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing

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Mitochondrial Transfer Ameliorates Cognitive Deficits, Neuronal Loss, and Gliosis in Alzheimer’s Disease Mice

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The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection

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Iron oxide nanoparticles augment the intercellular mitochondrial transfer–mediated therapy

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Forms of extracellular mitochondria and their impact in health

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Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis

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Mitochondria on the move: Horizontal mitochondrial transfer in disease and health

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Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis

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Mitochondrial stress and mitokines in aging

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Mitochondria transplantation between living cells

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Current progress of mitochondrial transplantation that promotes neuronal regeneration

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Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact

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Intranasal delivery of mitochondria for treatment of Parkinson’s Disease model rats lesioned with 6-hydroxydopamine

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Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment

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Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions

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Mitochondrial transplantation for organ rescue

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A 3D Biohybrid Real‐Scale Model of the Brain Cancer Microenvironment for Advanced In Vitro Testing

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Comparison of similar cells: Mesenchymal stromal cells and fibroblasts

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Intercellular Communication in Tumor Biology: A Role for Mitochondrial Transfer

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Mitochondrial Transplantation in Mitochondrial Medicine: Current Challenges and Future Perspectives

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Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment

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Targeted mitochondrial delivery: A therapeutic new era for disease treatment

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Autologous mitochondrial microinjection; a strategy to improve the oocyte quality and subsequent reproductive outcome during aging

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Mitochondrial Transfer as a Therapeutic Strategy Against Ischemic Stroke

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High-efficiency quantitative control of mitochondrial transfer based on droplet microfluidics and its application on muscle regeneration

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Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications

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The role of mitochondrial dysfunction in Alzheimer's disease: A potential pathway to treatment

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Radiotherapy resistance: identifying universal biomarkers for various human cancers

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Nanozyme‐Based Artificial Organelles: An Emerging Direction for Artificial Organelles

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Musculoskeletal Progenitor/Stromal Cell-Derived Mitochondria Modulate Cell Differentiation and Therapeutical Function

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Intercellular mitochondrial transfer in the brain, a new perspective for targeted treatment of central nervous system diseases

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The diversity and coexistence of extracellular mitochondria in circulation: A friend or foe of the immune system

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Pathogenic Mitochondria DNA Mutations: Current Detection Tools and Interventions

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Mitochondria: emerging therapeutic strategies for oocyte rescue

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Mitochondrial transplantation: A promising therapy for mitochondrial disorders

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Fighting Parkinson’s disease: The return of the mitochondria

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Mitochondria: A worthwhile object for ultrastructural qualitative characterization and quantification of cells at physiological and pathophysiological states using conventional transmission electron microscopy

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Primary allogeneic mitochondrial mix (PAMM) transfer/transplant by MitoCeption to address damage in PBMCs caused by ultraviolet radiation

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Platelets Facilitate Wound Healing by Mitochondrial Transfer and Reducing Oxidative Stress in Endothelial Cells

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Targeting autophagy and mitophagy for mitochondrial diseases treatment

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Bases for Treating Skin Aging With Artificial Mitochondrial Transfer/Transplant (AMT/T)

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The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease’s cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity

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Mitochondrial Transplantation for Ischemia Reperfusion Injury

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Automated Optical Tweezers Manipulation to Transfer Mitochondria from Fetal to Adult MSCs to Improve Antiaging Gene Expressions

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The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions

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Requirements for successful mitochondrial transplantation

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Extracellular mitochondria in the cerebrospinal fluid (CSF): Potential types and key roles in central nervous system (CNS) physiology and pathogenesis

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Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit

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Mitochondrial transfer - a novel promising approach for the treatment of metabolic diseases

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The Mighty Mitochondria Are Unifying Organelles and Metabolic Hubs in Multiple Organs of Obesity, Insulin Resistance, Metabolic Syndrome, and Type 2 Diabetes: An Observational Ultrastructure Study

Hayden, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094820 · Cited by 31 · see citing works

Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice

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A mitochondrial nexus in major depressive disorder: Integration with the psycho-immune-neuroendocrine network

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Use of Human Umbilical Cord and Its Byproducts in Tissue Regeneration

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Mitochondria Have Made a Long Evolutionary Path from Ancient Bacteria Immigrants within Eukaryotic Cells to Essential Cellular Hosts and Key Players in Human Health and Disease

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Mitochondrial donation in translational medicine; from imagination to reality

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Extracellular Vesicles, Apoptotic Bodies and Mitochondria: Stem Cell Bioproducts for Organ Regeneration

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Mitochondrial MicroRNAs Contribute to Macrophage Immune Functions Including Differentiation, Polarization, and Activation

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Targeting mitochondria for ovarian aging: new insights into mechanisms and therapeutic potential

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Could Mesenchymal Stem Cell-Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients?

Gardin, C., Ferroni, L., Chachques, J. C., & Zavan, B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092762 · Cited by 26 · see citing works

Mitochondrial transfer from mesenchymal stem cells: Mechanisms and functions

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Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4 + T Cells in Aging

Headley, C. A., Gautam, S., Olmo-Fontánez, A. M., Garcia‐Vilanova, A., Dwivedi, V., Akhter, A., Schami, A., Chiem, K., Ault, R., Zhang, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202303664 · Cited by 24 · see citing works

Cytoplasmic Transfer Improves Human Egg Fertilization and Embryo Quality: an Evaluation of Sibling Oocytes in Women with Low Oocyte Quality

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Decoding the nature and complexity of extracellular mtDNA: Types and implications for health and disease

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Powering prescription: Mitochondria as “Living Drugs” – Definition, clinical applications, and industry advancements

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Mitochondrial Transplantation/Transfer: Promising Therapeutic Strategies for Spinal Cord Injury

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Mitochondria: A Potential Rejuvenation Tool against Aging

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Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment

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Emerging Landscape of Cell-Penetrating Peptide-Mediated Organelle Restoration and Replacement

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Letter by McCully et al Regarding Article, “Mitochondria Do Not Survive Calcium Overload"

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The Role of Astrocytic Mitochondria in the Pathogenesis of Brain Ischemia

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Bridging the Gap: Animal Models in Next-Generation Reproductive Technologies for Male Fertility Preservation

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Stable retention of chloramphenicol-resistant mtDNA to rescue metabolically impaired cells

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Leber’s hereditary optic neuropathy: Current approaches and future perspectives on Mesenchymal stem cell-mediated rescue

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Mitochondrial transplantation and transfer: The promising method for diseases

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Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential

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Mitochondrial destabilization in tendinopathy and potential therapeutic strategies

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Mitochondrial Transplantation Moderately Ameliorates Retinal Degeneration in Royal College of Surgeons Rats

Wu, S.-F., Lin, C.-Y., Tsai, R., Wen, Y., Lin, F., Chang, C.-Y., Shen, C., Lin, S., Harn, H., Chiou, T., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10112883 · Cited by 16 · see citing works

Mitochondrial Dysfunction in Mitochondrial Medicine: Current Limitations, Pitfalls, and Tomorrow

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One step forward: extracellular mitochondria transplantation

Popov, L. (2021) · Cell and Tissue Research · doi:10.1007/s00441-021-03428-5 · Cited by 16 · see citing works

Engineered Mitochondrial Transplantation as An Anti-Aging Therapy

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Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue

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Artificial mitochondrial transplantation (AMT) reverses aging of mesenchymal stromal cells and improves their immunomodulatory properties in LPS-induced synoviocytes inflammation

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