Cited by 383Cancer, Hypoxia, and MetabolismRedox biology and oxidative stressAngiogenesis and VEGF in Cancer

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Oxygen, a source of life and stress

Brahimi-Horn, M. Christiane, Pouysségur, Jacques·2007·FEBS Letters

DOI 10.1016/j.febslet.2007.06.018

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Abstract

Oxygen is an essential element in the survival of complex organisms, however the level of oxygen, low or high, can be a source of stress depending on the biological context. Low levels of oxygen in tissues (hypoxia) can be the consequence of a number of pathophysiological conditions including ischemic disorders and cancer while relative, higher levels (hyperoxia) can lead to retinopathy of prematurity. The local oxygen environment and oxygen consumption dictate vascular homeostasis, vaso‐proliferation and vaso‐cessation, which is deregulated in these diseases through oxygen‐dependent growth factors. In this review, we will introduce aspects of the physiology and biology of oxygen partial pressure and the molecular mechanisms implicated in oxygen sensing. We will outline the regulation and function of the key operator in cellular signalling of hypoxia, the transcription factor, hypoxia‐inducible factor. In addition, we will focus on cancer cell hypoxia and on its role in driving cell metabolism, pH regulation and survival.

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Authors: Brahimi-Horn, M. C., & Pouysségur, J.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Brahimi-Horn, M. Christiane
ORCID: Pouysségur, Jacques
Venue: FEBS Letters
Publisher: Wiley
Published: 2007-06-19
Volume: 581
Issue: 19
Pages: 3582-3591
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2007.06.018
OpenAlex: W1983199304
Cited by: 383
References: 71
Citations by year: 2026: 3 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 16 · 2021: 23 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 26 · 2016: 22 · 2015: 18 · 2014: 24 · 2013: 37 · 2012: 13
FWCI: 1.88
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Centre National de la Recherche Scientifique
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: oxygen, hypoxia, hyperoxia, hypoxia-inducible factor, oxygen sensing, oxygen partial pressure, cellular metabolism, pH control, retinopathy of prematurity, ischemic disorders, vascular homeostasis
MeSH terms: Acidosis, Hypoxia, Glucose, Humans, Neoplasms, Oxygen, Partial Pressure, Signal Transduction, Heat-Shock Response, Hypoxia-Inducible Factor 1

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