Oxygen, a source of life and stress

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717

Why Do Cancers Have High Aerobic Glycolysis?

Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Kim, J.-W., Tchernyshyov, I., Semenza, G. L., & Dang, C. V. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.002 · Cited by 3,905

Angiogenesis as a therapeutic target

Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019

Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676

p53 Regulates Mitochondrial Respiration

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

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Glycolysis inhibition for anticancer treatment

Pelicano, H., Martin, D. S., Xu, R., & Huang, P. (2006) · Oncogene · doi:10.1038/sj.onc.1209597 · Cited by 1,546

Death by design: apoptosis, necrosis and autophagy

Edinger, A. L., & Thompson, C. B. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.011 · Cited by 1,362

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

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HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

Fukuda, R., Zhang, H., Kim, J.-W., Shimoda, L., Dang, C. V., & Semenza, G. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.047 · Cited by 1,225

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990

Tumor microenvironmental physiology and its implications for radiation oncology

Vaupel, P. W. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.008 · Cited by 966

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis

Cardone, R. A., Casavola, V., & Reshkin, S. J. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1713 · Cited by 897

The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Ullah, M. S., Davies, A. J., & Halestrap, A. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511397200 · Cited by 894

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

Zhang, H., Gao, P., Fukuda, R., Kumar, G., Krishnamachary, B., Zeller, K. I., Dang, C. V., & Semenza, G. L. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.04.001 · Cited by 885

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870

The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis: Figure 1

Greijer, A. E., & van der Wall, E. (2004) · Journal of Clinical Pathology · doi:10.1136/jcp.2003.015032 · Cited by 798

HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity

Gordan, J. D., Bertout, J. A., Hu, C.-J., Diehl, J. A., & Simon, M. C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.006 · Cited by 781

Expression of Hypoxia-Inducible Cell-Surface Transmembrane Carbonic Anhydrases in Human Cancer

Ivanov, S. V., Liao, S., Ivanova, A. V., Danilkovitch‐Miagkova, A., Tarasova, N. I., Weirich, G., Merrill, M. J., Proescholdt, M. A., Oldfield, E. H., Lee, J., et al. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64038-2 · Cited by 681

Glycolytic Enzymes Can Modulate Cellular Life Span

Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A., & Beach, D. (2005) · Cancer Research · doi:10.1158/0008-5472.177.65.1 · Cited by 647

Mitochondrial tumour suppressors: a genetic and biochemical update

Gottlieb, E., & Tomlinson, I. P. M. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1737 · Cited by 626

The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

Schieke, S. M., Phillips, D., McCoy, J. P., Aponte, A. M., Shen, R.-F., Balaban, R. S., & Finkel, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603536200 · Cited by 623

Tissue oxygen tension and brain sensitivity to hypoxia

Erecińska, M., & Silver, I. A. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00306-1 · Cited by 615

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

Rankin, E. B., Biju, M. P., Liu, Q., Unger, T. L., Rha, J., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30117 · Cited by 596

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell · doi:10.1016/j.cell.2004.08.025 · Cited by 588

Regulation of tumor pH and the role of carbonic anhydrase 9

Swietach, P., Vaughan-Jones, R. D., & Harris, A. L. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9064-0 · Cited by 539

Proline hydroxylation and gene expression

Kaelin, W. G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133142 · Cited by 468

Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3

Kubasiak, L. A., Hernandez, O. M., Bishopric, N. H., & Webster, K. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202474099 · Cited by 438

Lactate: mirror and motor of tumor malignancy

Walenta, S., & Mueller‐Klieser, W. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.004 · Cited by 432

Akt-dependent transformation: there is more to growth than just surviving

Plas, D. R., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1209097 · Cited by 431

Targeting tumor-associated carbonic anhydrase IX in cancer therapy

Thiry, A., Dogné, J., Masereel, B., & Supuran, C. T. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.09.002 · Cited by 396

Hypoxia and Glucose Metabolism in Malignant Tumors

Rajendran, J. G., Mankoff, D. A., O’Sullivan, F., Peterson, L. M., Schwartz, D. L., Conrad, E. U., Spence, A. M., Muzi, M., Farwell, D. G., & Krohn, K. A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0688-3 · Cited by 389

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

Kim, J.-W., Zeller, K. I., Wang, Y., Jegga, A. G., Aronow, B. J., O'Donnell, K. A., & Dang, C. V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5923-5936.2004 · Cited by 371

The Expanding Family of Eucaryotic Na+/H+Exchangers

Counillon, L., & Pouysségur, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.1 · Cited by 371

Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics

Gerweck, L. E., Vijayappa, S., & Kozin, S. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0024 · Cited by 362

Retinal degeneration and local oxygen metabolism

Yu, D., & Cringle, S. J. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.018 · Cited by 360

Cell-Permeating α -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

MacKenzie, E. D., Selak, M. A., Tennant, D. A., Payne, L. J., Crosby, S., Frederiksen, C. M., Watson, D. G., & Gottlieb, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01927-06 · Cited by 359

Signalling hypoxia by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.111 · Cited by 343

Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S. (2006) · Genes & Development · doi:10.1101/gad.1363206 · Cited by 321

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells

Wang, V., Davis, D. A., Haque, M., Huang, E. L., & Yarchoan, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4130 · Cited by 317

The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α

Dayan, F., Roux, D., Brahimi-Horn, M. C., Pouyssegur, J., & Mazure, N. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4564 · Cited by 294

Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents

Braun, R. D., Lanzen, J. L., Snyder, S. A., & Dewhirst, M. W. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2533 · Cited by 285

Hypoxia Inducible Carbonic Anhydrase IX, Marker of Tumour: Hypoxia, Survival Pathway and Therapy Target

Potter, C. T., & Harris, A. L. (2004) · Cell Cycle · doi:10.4161/cc.3.2.618 · Cited by 279

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

Hewitson, K. S., Liénard, B. M. R., McDonough, M. A., Clifton, I. J., Butler, D., Soares, A. S., Oldham, N. J., McNeill, L. A., & Schofield, C. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608337200 · Cited by 235

HIF‐1α and CA IX staining in invasive breast carcinomas: Prognosis and treatment outcome

Trastour, C., Benizri, E. I., Ettore, F., Ramaioli, A., Chamorey, E., Pouysségur, J., & Berra, E. (2007) · International Journal of Cancer · doi:10.1002/ijc.22436 · Cited by 233

Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications

Brahimi‐Horn, C., Mazure, N. M., & Pouysségur, J. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.04.010 · Cited by 222

Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors

Aprelikova, O. N., Chandramouli, G. V. R., Wood, M. J. A., Vasselli, J. R., Riss, J., Maranchie, J. K., Linehan, W. M., & Barrett, J. C. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20067 · Cited by 216

HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes

Shimoda, L. A., Fallon, M., Pisarcik, S., Wang, J., & Semenza, G. L. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00528.2005 · Cited by 209

The hypoxia‐inducible‐factor hydroxylases bring fresh air into hypoxia signalling

Berra, E., Ginouvès, A., & Pouysségur, J. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400598 · Cited by 205

Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer

Hussain, S. A., Ganesan, R., Reynolds, G. M., Gross, L., Stevens, A., Pastorek, J., Murray, P. G., Perunović, B., Anwar, M. S., Billingham, L. J., et al. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603530 · Cited by 198

Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel–Lindau renal cell carcinoma

Petrella, B. L., Lohi, J., & Brinckerhoff, C. (2004) · Oncogene · doi:10.1038/sj.onc.1208305 · Cited by 195

Cancer: looking outside the genome

Folkman, J., Hahnfeldt, P., & Hlatky, L. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036100 · Cited by 193

Ras Inhibition in Glioblastoma Down-regulates Hypoxia-Inducible Factor-1α, Causing Glycolysis Shutdown and Cell Death

Blum, R., Jacob‐Hirsch, J., Amariglio, N., Rechavi, G., & Kloog, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.999.65.3 · Cited by 190

Altitude is a phenotypic modifier in hereditary paraganglioma type�1: evidence for an oxygen-sensing defect

Astrom, K., Cohen, J. E., Willett-Brozick, J. E., Aston, C. E., & Baysal, B. E. (2003) · Human Genetics · doi:10.1007/s00439-003-0969-6 · Cited by 187

Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway

Pollard, P. J., Spencer‐Dene, B., Shukla, D., Howarth, K. M., Nye, E. L., El-Bahrawy, M. A., Deheragoda, M. G., Kolatsi‐Joannou, M., McDonald, S. A. C., Martin, A., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.02.005 · Cited by 182

Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death.

Blum, R., Jacob‐Hirsch, J., Amariglio, N., Rechavi, G., & Kloog, Y. (2005) · PubMed · Cited by 178

Induction of the Heat Shock Pathway during Hypoxia Requires Regulation of Heat Shock Factor by Hypoxia-inducible Factor-1

Baird, N. A., Turnbull, D. W., & Johnson, E. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608013200 · Cited by 169

RACK1 vs. HSP90: Competition for HIF-1α Degradation vs. Stabilization

Liu, Y. V., & Semenza, G. L. (2007) · Cell Cycle · doi:10.4161/cc.6.6.3981 · Cited by 162

The NHERF1 PDZ2 Domain Regulates PKA–RhoA–p38-mediated NHE1 Activation and Invasion in Breast Tumor Cells

Cardone, R. A., Bellizzi, A., Busco, G., Weinman, E. J., Dell’Aquila, M. E., Casavola, V., Azzariti, A., Mangia, A., Paradiso, A., & Reshkin, S. J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0617 · Cited by 136

Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment

Papandreou, I., Krishna, C. H. R., Kaper, F., Cai, D., Giaccia, A. J., & Denko, N. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3395 · Cited by 128

Transport Activity of MCT1 Expressed in Xenopus Oocytes Is Increased by Interaction with Carbonic Anhydrase

Becker, H. M., Hirnet, D., Fecher‐Trost, C., Sültemeyer, D. F., & Deitmer, J. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503081200 · Cited by 104

Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

Lau, K. W., Tian, Y.-M., Raval, R. R., Ratcliffe, P. J., & Pugh, C. W. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603675 · Cited by 104

Hypoxia-inducible Factor 2α Regulates Expression of the Mitochondrial Aconitase Chaperone Protein Frataxin

Oktay, Y., Dioum, E. M., Matsuzaki, S., Ding, K., Yan, L., Haller, R. G., Szweda, L. I., & Garcia, J. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611133200 · Cited by 94

BNip3 and signal-specific programmed death in the heart

Webster, K. A., Graham, R. M., & Bishopric, N. H. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.11.007 · Cited by 92

The Hypoxia-Inducible Factor and Tumor Progression Along the Angiogenic Pathway

Brahimi-Horn, M. C., & Pouysségur, J. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)42004-x · Cited by 87

Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis

Tsutsumi, S., Yanagawa, T., Shimura, T., Kuwano, H., & Raz, A. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1015 · Cited by 81

Angiogenesis and hypoxia in lymph node metastases is predicted by the angiogenesis and hypoxia in the primary tumour in patients with breast cancer

den Eynden, G. G. V., der Auwera, I. V., Laere, S. V., Colpaert, C., Turley, H., Harris, A. L., van Dam, P. A., Dirix, L. Y., Vermeulen, P., & Marck, E. A. V. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602828 · Cited by 56

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

Supuran, C. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2467 · Cited by 3,226

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891

Adipose tissue remodeling and obesity

Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941

Redox regulation of cell survival

Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781

Molecular responses to hypoxia: ancient pathways, clinical promises

Kim, W. Y., & Ivan, M. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00882.x

Hypoxia

Moses, M. A. (2013) · Springer eBooks · doi:10.1007/978-1-4419-9863-7_1546

Hypoxia‐mediated biological control

Cassavaugh, J. M., & Lounsbury, K. M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22956 · Cited by 177

Guest editorial: hypoxia biology in health and disease

Goda, N. (2012) · International Journal of Hematology · doi:10.1007/s12185-012-1084-z · Cited by 3

Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer

Ratcliffe, P. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.251470 · Cited by 294