Pouysségur, Jacques

Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 1,676

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J., & Mazure, N. M. (2009) · Molecular and Cellular Biology

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 1,501

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 1,348

The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

Meloche, S., & Pouysségur, J. (2007) · Oncogene

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 1,091

Hypoxia and cancer

Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J. (2007) · Journal of Molecular Medicine

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 765

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 588

Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory

Mazzucchelli, C., Vantaggiato, C., Ciamei, A., Fasano, S., Pakhotin, P., Krezel, W., Welzl, H., Wolfer, D. P., Pagès, G., Valverde, O., et al. (2002) · Neuron

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 456

Oxygen, a source of life and stress

Brahimi-Horn, M. C., & Pouysségur, J. (2007) · FEBS Letters

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 383

Growth Factor Action and Intracellular pH Regulation in Fibroblasts. Evidence for a Major Role of the Na+/H+ Antiport

L'Allemain, G., Paris, S., & Pouysségur, J. (1984) · Journal of Biological Chemistry

Ion Transport and Channel RegulationProtein Kinase Regulation and GTPase Signaling

Cited by 350

PHD2 Mutation and Congenital Erythrocytosis with Paraganglioma

Ladroue, C., Carcenac, R., Leporrier, M., Gad, S., Le Hello, C., Galateau-Salle, F., Feunteun, J., Pouysségur, J., Richard, S., & Gardie, B. (2008) · New England Journal of Medicine

Adrenal and Paraganglionic TumorsCancer, Hypoxia, and Metabolism

Cited by 323

p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts

Milanini, J., Viñals, F., Pouysségur, J., & Pagès, G. (1998) · Journal of Biological Chemistry

Angiogenesis and VEGF in CancerProtein Kinase Regulation and GTPase Signaling

Cited by 315

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H(+) symporters

Marchiq, I., & Pouysségur, J. (2016) · Journal of Molecular Medicine

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 300

Hypoxia signalling controls metabolic demand

Brahimi-Horn, M. C., Chiche, J., & Pouysségur, J. (2007) · Current Opinion in Cell Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 298

Redox regulation of the hypoxia-inducible factor

Pouysségur, J., & Mechta-Grigoriou, F. (2006) · Biological Chemistry

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 186

Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability

Pagès, G., Berra, E., Milanini, J., Levy, A. P., & Pouysségur, J. (2000) · Journal of Biological Chemistry

RNA Research and SplicingAngiogenesis and VEGF in Cancer

Cited by 184

Deletion of ERK1 and ERK2 in the CNS Causes Cortical Abnormalities and Neonatal Lethality:Erk1 Deficiency Enhances the Impairment of Neurogenesis in Erk2-Deficient Mice

Satoh, Y., Kobayashi, Y., Takeuchi, A., Pagès, G., Pouysségur, J., & Kazama, T. (2011) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 66

Transient blockade of ERK phosphorylation in the critical period causes autistic phenotypes as an adult in mice

Yufune, S., Satoh, Y., Takamatsu, I., Ohta, H., Kobayashi, Y., Takaenoki, Y., Pagès, G., Pouysségur, J., Endo, S., & Kazama, T. (2015) · Scientific Reports

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 57

Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system

Otsubo, Y., Satoh, Y., Kodama, M., Araki, Y., Satomoto, M., Sakamoto, E., Pagès, G., Pouysségur, J., Endo, S., & Kazama, T. (2012) · Pain

Pain Mechanisms and TreatmentsPain Management and Treatment

Cited by 33