The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Oxygen, a source of life and stress
Abstract
Oxygen is an essential element in the survival of complex organisms, however the level of oxygen, low or high, can be a source of stress depending on the biological context. Low levels of oxygen in tissues (hypoxia) can be the consequence of a number of pathophysiological conditions including ischemic disorders and cancer while relative, higher levels (hyperoxia) can lead to retinopathy of prematurity. The local oxygen environment and oxygen consumption dictate vascular homeostasis, vaso‐proliferation and vaso‐cessation, which is deregulated in these diseases through oxygen‐dependent growth factors. In this review, we will introduce aspects of the physiology and biology of oxygen partial pressure and the molecular mechanisms implicated in oxygen sensing. We will outline the regulation and function of the key operator in cellular signalling of hypoxia, the transcription factor, hypoxia‐inducible factor. In addition, we will focus on cancer cell hypoxia and on its role in driving cell metabolism, pH regulation and survival.
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“A master regulator of hypoxia and oxygen homeostasis is HIF-1 (26,27).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [27]
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Cites
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Why Do Cancers Have High Aerobic Glycolysis?
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Angiogenesis as a therapeutic target
Ferrara, N., & Kerbel, R. S. (2005) · Nature · doi:10.1038/nature04483 · Cited by 2,653
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267
TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
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Ras, PI(3)K and mTOR signalling controls tumour cell growth
Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019
Hypoxia signalling in cancer and approaches to enforce tumour regression
Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676
Self-citationp53 Regulates Mitochondrial Respiration
Matoba, S., Kang, J.-G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., & Hwang, P. M. (2006) · Science · doi:10.1126/science.1126863 · Cited by 1,650
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Research works printed but not linked: 1
- 2001 John Wiley & Sons Ltd J. Pouyssegur A. Franchi G. Pages Novartis Found Symposium 186 196
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Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Supuran, C. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2467 · Cited by 3,226
Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,891
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., & Semenza, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800102200 · Cited by 1,601
Retracted
Metadata
- Authors
- Brahimi-Horn, M. C., & Pouysségur, J.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Brahimi-Horn, M. Christiane
- ORCID
- Pouysségur, Jacques
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-06-19
- Volume
- 581
- Issue
- 19
- Pages
- 3582-3591
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1983199304
- Cited by
- 383
- References
- 71
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 16 · 2021: 23 · 2020: 20 · 2019: 28 · 2018: 20 · 2017: 26 · 2016: 22 · 2015: 18 · 2014: 24 · 2013: 37 · 2012: 13
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- oxygen, hypoxia, hyperoxia, hypoxia-inducible factor, oxygen sensing, oxygen partial pressure, cellular metabolism, pH control, retinopathy of prematurity, ischemic disorders, vascular homeostasis
- MeSH terms
- Acidosis, Hypoxia, Glucose, Humans, Neoplasms, Oxygen, Partial Pressure, Signal Transduction, Heat-Shock Response, Hypoxia-Inducible Factor 1
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