Cited by 1,161Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Inflammation and insulin resistance

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de Luca, Carl, Olefsky, Jerrold M.·2008·FEBS Letters

DOI 10.1016/j.febslet.2007.11.057PMC PMC2246086

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Abstract

Obesity‐induced chronic inflammation is a key component in the pathogenesis of insulin resistance and the Metabolic syndrome. In this review, we focus on the interconnection between obesity, inflammation and insulin resistance. Pro‐inflammatory cytokines can cause insulin resistance in adipose tissue, skeletal muscle and liver by inhibiting insulin signal transduction. The sources of cytokines in insulin resistant states are the insulin target tissue themselves, primarily fat and liver, but to a larger extent the activated tissue resident macrophages. While the initiating factors of this inflammatory response remain to be fully determined, chronic inflammation in these tissues could cause localized insulin resistance via autocrine/paracrine cytokine signaling and systemic insulin resistance via endocrine cytokine signaling all of which contribute to the abnormal metabolic state.

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Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Toll-like receptor control of the adaptive immune responses
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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss, R., Dziura, J., Burgert, T. S., Tamborlane, W. V., Taksali, S. E., Yeckel, C. W., Allen, K., Lopes, M., Savoye, M., Morrison, J. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031049 · Cited by 3,495

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Solinas G. Vilcu C. Neels J.G. Luo J.-L. Naugler W. Olefsky J.M. and Karin M. (2007) JNK in macrophages plays a key role in the development of obesity-induced insulin resistance in: Proceedings of Keystone Symposium: Metabolic Syndrome and Cardiovascular Disease Steamboat Springs CO.
deLuca C. Saberi M. Schenk S. Lu J.-C. Castorena C. Greenberg A.W. and Olefsky J.M. (2007) Myeloid-derived Toll-like receptor 4 (Tlr4) is required for high fat diet induced hepatic insulin resistance in: Proceedings of Keystone Symposium: Metabolic Syndrome and Cardiovascular Disease Steamboat Springs CO.

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Alnaeeli, M., Raaka, B. M., Gavrilova, O., Teng, R., Chanturiya, T., & Noguchi, C. T. (2014) · Diabetes · doi:10.2337/db13-0883 · Cited by 53
Cross-Kingdom Actions of Phytohormones: A Functional Scaffold Exploration
Lin, L., & Tan, R. X. (2011) · Chemical Reviews · doi:10.1021/cr100061j · Cited by 54
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Magee, M. J., Salindri, A. D., Kyaw, N. T. T., Auld, S. C., HAW, J. S., & Umpierrez, G. E. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1036-y · Cited by 59
Role of Cannabinoid Receptor Type 1 in Insulin Resistance and Its Biological Implications
Nagappan, A., Shin, J., & Jung, M. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092109 · Cited by 56
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Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome and diabetes.
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Mao, W., Ning, M., Liu, Z., Zhu, Q., Leng, Y., & Zhang, A. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.03.008 · Cited by 50
Increased Smad signaling and reduced MRF expression in skeletal muscle from obese subjects
Watts, R., McAinch, A. J., Dixon, J. B., O’Brien, P. E., & Cameron‐Smith, D. (2013) · Obesity · doi:10.1002/oby.20070 · Cited by 52
Long‐term dietary supplementation with low‐dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet‐induced obesity
Kim, Y., Choi, M., Woo, J. T., Jeong, M. J., Kim, S. R., & Jung, U. J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600889 · Cited by 50
Association between dietary inflammatory index score and muscle mass and strength in older adults: a study from National Health and Nutrition Examination Survey (NHANES) 1999–2002
Chen, L., Ming, J., Chen, T., Hébert, J. R., Sun, P., Zhang, L., Wang, H., Wu, Q., Zhang, C., Shivappa, N., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-02941-9 · Cited by 50
Garcinol suppresses inflammation‐associated colon carcinogenesis in mice
Tsai, M., Chiou, Y., Chiou, L., Ho, C., & Pan, M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400149 · Cited by 49
Inflammatory NF-κB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production
Tsai, J., Zhang, R., Qiu, W., Su, Q., Naples, M., & Adeli, K. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90540.2008 · Cited by 49
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Omega‐3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers
Ferguson, J. F., Mulvey, C. K., Patel, P., Shah, R. Y., Doveikis, J., Zhang, W., Tabita‐Martinez, J., Terembula, K., Eiden, M. J., Koulman, A., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300368 · Cited by 48
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Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre‐diabetic women: a randomized double‐blind clinical trial
Kazemi, S., yaghooblou, F., Siassi, F., Foroushani, A. R., Ghavipour, M., Koohdani, F., & Sotoudeh, G. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8414 · Cited by 48
The role of glucose-6-phosphate dehydrogenase in adipose tissue inflammation in obesity
Park, Y. J., Choe, S. S., Sohn, J. H., & Kim, J. B. (2017) · Adipocyte · doi:10.1080/21623945.2017.1288321 · Cited by 48
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Authors: de Luca, C., & Olefsky, J. M.
Affiliations: University of California San Diego (US)
Corresponding author: Olefsky, Jerrold M.
ORCID: Olefsky, Jerrold M.
Venue: FEBS Letters
Publisher: Wiley
Published: 2007-11-29
Volume: 582
Issue: 1
Pages: 97-105
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2007.11.057
PMC: PMC2246086
OpenAlex: W2031882974
Cited by: 1,161
References: 66
Citations by year: 2026: 56 · 2025: 68 · 2024: 54 · 2023: 83 · 2022: 82 · 2021: 83 · 2020: 68 · 2019: 64 · 2018: 73 · 2017: 69 · 2016: 58 · 2015: 56 · 2014: 40 · 2013: 65 · 2012: 58
FWCI: 5.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 074868, DK 033651, T32DK007494, R37DK033651, DK007494, P01DK074868)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD012303)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: insulin resistance, obesity, chronic inflammation, metabolic syndrome, inflammatory cytokines, adipose tissue, skeletal muscle, liver, insulin signaling, macrophages, autocrine and paracrine signaling
MeSH terms: Humans, Inflammation, Insulin Resistance, Signal Transduction

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