Cited by 1,161Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Inflammation and insulin resistance

Open access

de Luca, Carl, Olefsky, Jerrold M.·2008·FEBS Letters

DOI 10.1016/j.febslet.2007.11.057PMC PMC2246086

Open this paper in CoChat — free account Open PDF

Abstract

Obesity‐induced chronic inflammation is a key component in the pathogenesis of insulin resistance and the Metabolic syndrome. In this review, we focus on the interconnection between obesity, inflammation and insulin resistance. Pro‐inflammatory cytokines can cause insulin resistance in adipose tissue, skeletal muscle and liver by inhibiting insulin signal transduction. The sources of cytokines in insulin resistant states are the insulin target tissue themselves, primarily fat and liver, but to a larger extent the activated tissue resident macrophages. While the initiating factors of this inflammatory response remain to be fully determined, chronic inflammation in these tissues could cause localized insulin resistance via autocrine/paracrine cytokine signaling and systemic insulin resistance via endocrine cytokine signaling all of which contribute to the abnormal metabolic state.

Integrity signals

Registry

Crossref · 10.1016/j.febslet.2007.11.057

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss, R., Dziura, J., Burgert, T. S., Tamborlane, W. V., Taksali, S. E., Yeckel, C. W., Allen, K., Lopes, M., Savoye, M., Morrison, J. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031049 · Cited by 3,495

Show all 66 references

Research works printed but not linked: 2

Solinas G. Vilcu C. Neels J.G. Luo J.-L. Naugler W. Olefsky J.M. and Karin M. (2007) JNK in macrophages plays a key role in the development of obesity-induced insulin resistance in: Proceedings of Keystone Symposium: Metabolic Syndrome and Cardiovascular Disease Steamboat Springs CO.
deLuca C. Saberi M. Schenk S. Lu J.-C. Castorena C. Greenberg A.W. and Olefsky J.M. (2007) Myeloid-derived Toll-like receptor 4 (Tlr4) is required for high fat diet induced hepatic insulin resistance in: Proceedings of Keystone Symposium: Metabolic Syndrome and Cardiovascular Disease Steamboat Springs CO.

Sorted by citations

Items 801–900 of 1,000

Acute hyperglycaemia in cystic fibrosis pulmonary exacerbations
Merjaneh, L., Toprak, D., McNamara, S., Nay, L., Sullivan, E. M., & Rosenfeld, M. (2020) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.208 · Cited by 7
Special Issue: The intersection of inflammation and metabolism in neuropsychiatric disorders
Felger, J. C., & Capuron, L. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.025 · Cited by 7
Potential associations between variants of genes encoding regulators of inflammation, and mediators of inflammation in type 2 diabetes and insulin resistance
Özbayer, C., Kebapçı, M. N., Kurt, H., Çolak, E., Güneş, H. V., & Değirmenci, İ. (2021) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13471 · Cited by 7
Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients
Ding, L., Munck, T. J. I. D., Oligschlaeger, Y., Verbeek, J., Koek, G. H., Houben, T., & Shiri‐Sverdlov, R. (2021) · BioMolecular Concepts · doi:10.1515/bmc-2021-0011 · Cited by 7
Relationship between Testosterone Level, Serum Omentin-1 and Insulin Resistance in Obese Men
El-Kaream, S. A. A., Abdel-Monem, S. M., Khalil, M., & Mohassab, G. I. (2015) · American Journal of Biomedical Sciences · doi:10.5099/aj150300134 · Cited by 7
Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation
van Eijk, M., Aten, J., Bijl, N., Ottenhoff, R., van Roomen, C. P. A. A., Dubbelhuis, P. F., Seemann, I., der Vlugt, K. G., Overkleeft, H. S., ARBEENY, C. M., et al. (2009) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2009.06.130 · Cited by 7
Approach to metabolic syndrome in childhood cancer survivors
Scott, J., Latha, M. S., & Aruna, R. M. (2015) · Indian Journal of Cancer · doi:10.4103/0019-509x.175840 · Cited by 8
Prospective associations of occupational and leisure-time physical activity with risk of diabetes: a cohort study from the United States
Matthews, T. A., Liu, X., Chen, L., & Li, J. (2024) · Annals of Work Exposures and Health · doi:10.1093/annweh/wxae034 · Cited by 7
Risk of Cardiovascular Events Associated with Chronic Obstructive Pulmonary Disease and/or Metabolic Syndrome: A Large-Scale Nationwide Population-Based Cohort Study
Noh, E., Jeong, H., Cho, I.-S., Chang, M.-S., Yu, I., Park, S., Lee, J.-H., Lee, S. J., Lee, W., Yong, S. J., et al. (2024) · International Journal of COPD · doi:10.2147/copd.s458779 · Cited by 6
Targeting Ferroptosis in Parkinson’s: Repurposing Diabetes Drugs as a Promising Treatment
Duţă, C., Muscurel, C., Dogaru, C. B., & Stoian, I. A.-M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041516 · Cited by 7
Managing Diabetic Complications with Alternative Therapeutic Strategies
Srivastava, S. P., Upadhyay, P., Das, S., Tiwari, N., Mishra, S. K., & Tripathi, S. M. (2023) · Current Diabetes Reviews · doi:10.2174/1573399820666230907112430 · Cited by 10
Anti-Inflammatory and Anti-Adipocyte Dysfunction Effects of Ficus lindsayana Latex and Root Extracts
Karinchai, J., Buacheen, P., Rodthayoy, D., Yodweerapong, T., Imsumran, A., Wongnoppavich, A., Chantarasuwan, B., Suttisansanee, U., Temviriyanukul, P., & Pitchakarn, P. (2024) · Pharmaceuticals · doi:10.3390/ph17030287 · Cited by 8
The Impact of Sodium-Glucose Co-Transporter-2 Inhibition on Insulin Resistance and Inflammation in Patients with Type 2 Diabetes: A Retrospective Study
Iordan, L., Lazăr, S., Timar, R. Z., Popescu, S. D., Sorescu, T., Albai, O., Braha, A., Timar, B., & Gaiţă, L. (2025) · Medicina · doi:10.3390/medicina61020209 · Cited by 9
The energy model of insulin resistance: A unifying theory linking seed oils to metabolic disease and cancer
Shanahan, C. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1532961 · Cited by 7
Effect of Phyllanthus emblica L. fruit on improving regulation of methylglyoxal-induced insulin resistance in 3T3-L1 cells
Chen, H.-C., Tung, Y., Chen, S.-Y., Lin, J., & Yen, G. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.4170 · Cited by 6
Etiopathogenesis of insulin resistance
Gupta, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820234-0.00010-x · Cited by 7
Construction of PIK3C3 Transgenic Pig and Its Pathogenesis of Liver Damage
Wang, J., Khan, S. U., Cao, P., Chen, X., Wang, F., Zou, D., Li, H., Zhao, H., Xu, K., Jiao, D., et al. (2022) · Life · doi:10.3390/life12050630 · Cited by 6
Effects of Nut Consumption on Cardiovascular Risk Factors and Coronary Heart Diseases
Zibaeenezhad, M. J., & Elyaspour, Z. (2022) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v12i11.1022 · Cited by 8
Serum gamma‐glutamyltransferase levels are related to insulin sensitivity and secretion in subjects with abnormal glucose regulation
Bianchi, C., Penno, G., Crisci, I., Daniele, G., Agostini, A., Prato, S. D., & Miccoli, R. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1069 · Cited by 6
Inflammation Friend or Foe?
Lewis, T. J., & Trempe, C. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812112-2.00007-0 · Cited by 8
Unprotected daily sun exposure is differently associated with central adiposity and beta-cell dysfunction by gender: The Korean national health and nutrition examination survey (KNHANES) V
Ohn, J. H., Kwon, I. H., Park, J., Ryu, O. H., Lee, S. J., Kim, D. M., Ihm, S., Choi, M. G., Yoo, H. J., & Hong, E. (2014) · Environmental Research · doi:10.1016/j.envres.2014.05.033 · Cited by 7
Depot-specific alterations to insulin signaling in mesenteric adipose tissue during intestinal inflammatory response
de Oliveira, C. C., Acedo, S. C., Pedrazzoli, J., Saad, M. J. A., & Gambero, A. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2008.12.015 · Cited by 6
Metabolic syndrome in psoriasis
Szponar-Bojda, A., Krasowska, D., Pietrzak, A., & Chodorowska, G. (2012) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2012.31488 · Cited by 6
Biomarkers, Obesity, and Cardiovascular Diseases
Meza, M. N., & Carrillo, J. A.-B. (2016) · InTech eBooks · doi:10.5772/62555 · Cited by 7
The Triglyceride-Glucose Index: A Novel Marker for Clinical Atherosclerotic Cardiovascular Disease Risk Stratification
Chikatimalla, R., Ruhela, N., Hazique, M., Trivedi, Y. V., Jain, P., Singh, B., & Jain, R. (2025) · Annals of African Medicine · doi:10.4103/aam.aam_74_25 · Cited by 5
Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes
Rajala, R., & Griffin, C. T. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.323140 · Cited by 5
Ethnic differences in adipose tissue dysfunction and insulin resistance: a scoping review
AlShehab, M., Costabile, A., Patterson, M., & Hakim, O. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112363 · Cited by 6
The relationship between the triglyceride-glucose index and lung function in healthy individuals: a cross-sectional study of 89,809 participants from Kangbuk Samsung health study
Gil, H., Lim, S., Kwon, M., Ham, S., Lee, J. H., & Song, J. (2025) · BMC Pulmonary Medicine · doi:10.1186/s12890-025-03869-6 · Cited by 5
Novel piperazine–triazole hybrids as PTP1B and alpha-amylase inhibitors: synthesis, biological evaluation and computational validation through network pharmacology, molecular docking, MD simulations, DFT and MMPBSA analysis
Haroon, M., Kamal, S., Mansha, A., & Zahoor, A. F. (2026) · RSC Advances · doi:10.1039/d6ra00931j · Cited by 5
Safety and antidiabetic activity of Lagenaria siceraria (Molina) Standl. juice in streptozotocin -induced diabetic rats
Das, M. J., Banerjee, D., Banerjee, A., Muchahary, S., Sinha, A., Gogoi, D., Chattopadhyay, P., Dasgupta, S., & Deka, S. C. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117111 · Cited by 5
Histone Deacetylase 9 Deletion Inhibits Hepatic Steatosis and Adipose Tissue Inflammation in Male Diet‐Induced Obese Mice
Hu, S., Kang, H., Bae, M., Kim, M., Jang, H., Corvino, O., Pham, T. X., Lee, Y., Smyth, J. A., Park, Y., et al. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16856 · Cited by 6
Insulin resistance and laminitis in broodmares
Galantino‐Homer, H. L., & Engiles, J. B. (2012) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2012.08.220 · Cited by 5
Effect of Gestational Diabetes Mellitus on the Growth, Development, and Stem Cells of Offspring
Zhang, M., Ma, M., Wang, J., Wang, Y., Yang, X., & Fu, S. (2021) · Maternal-Fetal Medicine · doi:10.1097/fm9.0000000000000130 · Cited by 5
Exploring the Therapeutic Potential of Apigenin in Obesity-Associated Fibrinolytic Dysfunction: Insights From an Animal Study
Qadi, H. H., Bendary, M., Almaghrabi, S., Zaher, M., Karami, M. M., Alsehli, A. M., Babateen, O., Arbaeen, A. F., Burzangi, A. S., & Bazuhair, M. A. (2023) · Cureus · doi:10.7759/cureus.40943 · Cited by 6
Management Updates on Prepartal Stress Effects on Transition Cow and Calf Health
Nikkhah, A., & Alimirzaei, M. (2023) · World s Veterinary Journal · doi:10.54203/scil.2023.wvj27 · Cited by 5
Benzyl isothiocyanate inhibits TNFα-driven lipolysis via suppression of the ERK/PKA/HSL signaling pathway in 3T3-L1 adipocytes
Li, C., Liu, K., Lii, C., Yan, W.-Y., Lo, C., Chen, C.-C., Yang, Y., & Chen, H.-W. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.11.007 · Cited by 5
Exploring the Link Between Metabolic Syndrome and Cellulite
Adamidis, N., Papalexis, P., & Adamidis, S. (2024) · Cureus · doi:10.7759/cureus.63464 · Cited by 5
Associations between dose–response of serum creatinine and type 2 diabetes mellitus risk: consistent and robust evidence from a systematic review and meta-analysis
Phuong, V. T. M., Quynh, V. T., Di, K. N., Duc, T. Q., & Hoang, N. H. (2024) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2024.2436890 · Cited by 6
Flavonoids Derived from Opuntia ficus-indica Fruit Alleviate Renal Injury in Diabetic Nephropathy Mice by Altering Gut Microbiota and Promoting the Production of SCFAs
Liao, H., Zhao, Y., Liang, Y., & Zou, K. (2025) · Nutrients · doi:10.3390/nu17111800 · Cited by 5
Perspectives on diabetes mortality as the result of residual confounding and reverse causality by common disease
Thuesen, A. C. B., & Vaag, A. A. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13238 · Cited by 5
Research Progresses of the Mechanism of Insulin Resistance in Type II Diabetes
Liu, X. (2019) · E3S Web of Conferences · doi:10.1051/e3sconf/20197801006 · Cited by 5
Effect of dietary fish oil on enhanced inflammation and disturbed lipophagy in white adipose tissue caused by a high fat diet
Saitoh, K., Yoshimura, T., Sun, L., Yang, M. H., Wang, Y., Taniyama, S., Hara, K., Murayama, F., Nikawa, T., Tachibana, K., et al. (2019) · Fisheries Science · doi:10.1007/s12562-019-01374-4 · Cited by 5
Obesity: A Prerequisite for Major Chronic Illnesses
Afolabi, H. A., Zakarıa, Z., Salleh, M. S. M., Ch’ng, E. S., Nafi, S. N. M., Aziz, A. A. A., Al-Mhanna, S. B., Irekeola, A. A., Wada, Y., & Daku, A. B. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.111935 · Cited by 8
Vagal Splenic‐Dependent Effects Influence Glucose Homeostasis, Insulin Secretion, and Histopathology of the Endocrine Pancreas in Hypothalamic Obese Male Rats
Siqueira, B. S., Gomes, E. C. Z., Rentz, T., Malta, A., Mathias, P. C. D. F., Balbo, S. L., & Grassiolli, S. (2025) · The Scientific World JOURNAL · doi:10.1155/tswj/9910997 · Cited by 4
Therapeutic efficacy of rhoifolin in type 2 diabetes mellitus: Effects on metabolic parameters, hepatic function, and oxidative stress: a dose-dependent study
Fattiny, S. Z. A., Binobead, M. A., Yagoub, A. E. A., Alshammari, G. M., Saleh, A. Y., & Yahya, M. A. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1595323 · Cited by 4
High N‐Terminal Pro‐B‐Type Natriuretic Peptide Levels Are Associated With Lower Physical Function Independent of Sarcopenia in Community‐Dwelling Older Adults: The Shizuoka Study
Kato, M., Tanaka, Y., Adachi, T., Kito, K., Nakano, W., Nakano, S., Kurita, Y., Miyoshi, K., Takagi, D., Kushida, O., et al. (2026) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.70494 · Cited by 4
The Psychiatric‐Metabolic Interface: Exploring the Interplay Between Mental Disorders and Metabolic Syndrome
Elias, L., Saroufine, K., Alagha, M., Beaini, C. E., Bekai, E. A., Semaan, S., Elkhoury, E., Harb, F., Azar, S. T., Khoury, N. B. E., et al. (2026) · Mental Illness · doi:10.1155/mij/4208707 · Cited by 4
Mapping the knowledge structure of research on insulin resistance and metabolic syndrome: a global perspective
Zyoud, S. H., Shakhshir, M. H., Abushanab, A. S., Koni, A. A., Shahwan, M. J., Jairoun, A. A., Taha, A. A., Abushamma, F., & Al‐Jabi, S. W. (2024) · Translational Medicine Communications · doi:10.1186/s41231-024-00165-z · Cited by 5
Contemporary insights into neuroimmune interactions across development and aging
Yeo, X. Y., Choi, Y., Hong, Y., Kwon, H. N., & Jung, S. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1611124 · Cited by 5
IRAK inhibitor can improve insulin sensitivity in insulin-resistant mice fed with a high-fat diet
Allahyari, M., Rajaie, A., & Fallah, H. (2020) · Asian Biomedicine · doi:10.1515/abm-2020-0034 · Cited by 4
Nutraceutical and Cosmeceutical Potential of Seaweed Derived Fucoxanthin
Sil, A., & Dasgupta, U. (2021) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.814 · Cited by 4
Different Structures—Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?
Zhuravlev, A. V., Cruz, A., Aksenov, V., Golovanov, A., Lluch, J. M., Kühn, H., González‐Lafont, À., & Ivanov, I. (2023) · Molecules · doi:10.3390/molecules28145418 · Cited by 4
The protective effects of sesamin against metabolic syndrome: A mechanistic review
Parsa, E., Javadi, B., & Sahebkar, A. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100625 · Cited by 7
Effect of Vitamin D Supplementation on Glycemic Control in Newly Diagnosed Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Kumar, K., Bordoloi, T., Narang, S., Kotru, M., & Singh, A. (2024) · Cureus · doi:10.7759/cureus.70224 · Cited by 4
Pathological Sequelae of SARS-CoV-2: A Review for Clinicians
Nyarko, J. A., Dogbe, P. M., Ativi, L. A. E., Wutsika, J., Agyenim, E. B., Awere‐Duodu, A., Botaeng, A. T., & Ntim, N. A. A. (2024) · The Yale Journal of Biology and Medicine · doi:10.59249/dqjh2274 · Cited by 4
Adipokines Have a Role to Play in the Treatment of Metabolic Disease
Russell, S. T. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.10.265 · Cited by 4
Effect of statins on atherogenic serum amyloid A and α1-antitrypsin low-density lipoprotein complexes
Miyazaki, Y., Katanasaka, Y., Sunagawa, Y., Hirano-Sunagawa, S., Funamoto, M., Morimoto, E., Komiyama, M., Shimatsu, A., Satoh‐Asahara, N., Yamakage, H., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.09.116 · Cited by 4
Association of mitochondrial dysfunction and lipid metabolism with type 2 diabetes mellitus: A review of literature
Haghani, K., Asadi, P., Taheripak, G., Noori-Zadeh, A., Darabi, S., & Bakhtiyari, S. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1521-3 · Cited by 4
Purpurin, a Natural Anthroquinone Ameliorates Streptozotocin-induced Diabetic Nephropathy via Attenuating Hyperglycemia, Dyslipidemia, and Inflammation in Rats
Shang, Y., & Mohideen, A. P. (2023) · Pharmacognosy Magazine · doi:10.1177/09731296231158477 · Cited by 4
Gooseberry anthocyanins alleviate insulin resistance by regulating ceramide metabolism in high fat diet mice
TANG, X., Gao, J., Huang, J., ZHANG, C., Liu, H., & Wei, J. (2023) · TURKISH JOURNAL OF BIOLOGY · doi:10.55730/1300-0152.2668 · Cited by 4
Obesity, Insulin Resistance, and Inflammaging
Itariu, B. K., & Stulnig, T. M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00013-7 · Cited by 5
Serum amylase and lipase activities in newly diagnosed patients with type 2 diabetes mellitus.
Kalita, S., Deori, R., Bhattacharyya, K., & Goswami, R. (2016) · International Journal of Advanced Research · doi:10.21474/ijar01/996 · Cited by 4
Physiological effects of carotenoids on hyperglycemia and associated events
Swamy, V., Alugoju, P., & Periyasamy, L. (2020) · Studies in natural products chemistry · doi:10.1016/b978-0-12-817903-1.00010-3 · Cited by 4
Adiposity and weight gain in Mangalarga Marchador horses subjected to hypercaloric diet
Ribeiro, R. M., Ribeiro, D. S. F., Paz, C. F. R., Gobesso, A. A. D. O., & Faleiros, R. R. (2020) · Pesquisa Veterinária Brasileira · doi:10.1590/1678-5150-pvb-6178 · Cited by 4
Viral clearance ameliorates hematological and inflammatory markers among diabetic patients infected with hepatitis C genotype 4
Moneim, A., Suleiman, H. A., Mahmoud, B., Mabrouk, D., & Zaky, M. Y. (2020) · Clinical and Experimental Medicine (Testo stampato) · doi:10.1007/s10238-019-00605-3 · Cited by 4
Tumor suppressor and anti-inflammatory protein: an expanded view on insulin-degrading enzyme (IDE)Preprint
Radulescu, R. T. (2008) · arXiv (Cornell University) · doi:10.48550/arxiv.0812.0160 · Cited by 4
Antidiabetic activities of ethyl acetate and aqueous extracts of pappea capensis, senna spectabilis, maytenus obscura, ocimum americanum and launaea cornuta
Karau, G. M. (2014) · Cited by 4
Astaxanthin and Fucoxanthin
Barbosa, M., Valentão, P., & Andrade, P. B. (2020) · Wiley eBooks · doi:10.1002/9781119143802.ch59 · Cited by 5
Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis
Albers, F. E. M., Swain, C. T. V., Lou, M. W. C., Dashti, S. G., Rinaldi, S., Viallon, V., Karahalios, A., Brown, K. A., Gunter, M. J., Milne, R. L., et al. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-24-1304 · Cited by 5
Combined effect of chronic inflammation and insulin resistance on stroke: a cohort study and mediation analysis
Gao, Y., Duan, Z., Li, J., Du, S., Song, L., Zhao, R., Hou, Y., Zhao, Y., & Li, Y. (2025) · European journal of medical research · doi:10.1186/s40001-025-03375-9 · Cited by 3
Metabolic and inflammatory axes of insulin resistance in normoglycemic adults with high HIV burden
Liweleya, S., Halubanza, B., Muchaili, L., Mweene, B. C., Siame, L., Lwiindi, P. C., Hamooya, B. M., Povia, J. P., Chabala, F. M., Sinkala, M., et al. (2026) · PLOS Global Public Health · doi:10.1371/journal.pgph.0005589 · Cited by 3
Impaired cytokines in diabetes and diabetic foot ulcers: mechanisms and prospects
Alam, A., Momi, S., Riyaz, H., Behado, O., & Rai, V. (2026) · Exploration of Endocrine and Metabolic Diseases · doi:10.37349/eemd.2026.101457 · Cited by 3
Insulin resistance in type 1 diabetes: the silent burden unmasked by eGDR
Ismael, A. H., & Hameed, E. K. (2026) · Acta Diabetologica · doi:10.1007/s00592-026-02641-4 · Cited by 3
Capillary-Associated Microglia in Neurovascular Coupling: Localization, Mechanisms, and Disease Implications
Lu, H., Zhang, Y., Chen, C., Xie, H., Li, Y., & Qiu, S. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03723-4 · Cited by 3
Insulin resistance as a modifiable contributor to breast cancer: mechanisms, biomarkers, and therapeutic implications
Marouf, S. P., Meskar, Z., & Rezaei, N. (2026) · Discover Oncology · doi:10.1007/s12672-026-04828-1 · Cited by 3
SARS-CoV-2 Main Protease Dysregulates Hepatic Insulin Signaling and Glucose Uptake: Implications for Post-COVID-19 Diabetogenesis
Nhau, P. T., Gamede, M. W., Khathi, A., & Sibiya, N. H. (2025) · Pathophysiology · doi:10.3390/pathophysiology32030039 · Cited by 3
N-Lactoyl Phenylalanine Disrupts Insulin Signaling, Induces Inflammation, and Impairs Mitochondrial Respiration in Cell Models
Hedaya, L., Naja, K., Almuraikhy, S., Anwardeen, N. R., Elashi, A. A., Al‐Asmakh, M., Zughaier, S. M., Espino‐Guarch, M., Al-Dirbashi, O. Y., Davey, G. P., et al. (2025) · Cells · doi:10.3390/cells14161296 · Cited by 3
Absence of association between −286C>A>T polymorphism in the CRP gene and metabolic syndrome in Iranian pediatric
Nikpour, P., Emadi‐Baygi, M., Fatemi, S. G., & Kelishadi, R. (2015) · Advanced Biomedical Research · doi:10.4103/2277-9175.166147 · Cited by 3
Simulation of Cellular Energy Restriction in Quiescence (ERiQ)—A Theoretical Model for Aging
Alfego, D., & Kriete, A. (2017) · Biology · doi:10.3390/biology6040044 · Cited by 3
A Study of Insulin Resistance in Rheumatoid Arthritis
Dihingia, P., Choudhury, D., & Baruah, S. M. (2020) · International Journal of Contemporary Medical Research [IJCMR] · doi:10.21276/ijcmr.2020.7.2.23 · Cited by 3
Pathogenesis of Gestational Diabetes Mellitus
Kintiraki, E., Mintziori, G., & Goulis, D. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-25519-9_15 · Cited by 3
Altered insulin sensitivity and immune function in patients with colorectal cancer
Baban, B., Eklund, D., Tuerxun, K., Alshamari, M., Laviano, A., Ljungqvist, O. H., & Särndahl, E. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.09.917 · Cited by 3
Severe Insulin Resistance in a Patient Treated With Nivolumab and Brentuximab-Vedotin for Hodgkin Lymphoma
Tama, E., Black, M., Moustafa, M. A., & Hurtado, M. D. (2023) · JCEM Case Reports · doi:10.1210/jcemcr/luad121 · Cited by 3
The role of body mass index on the association between the energy-adjusted dietary inflammatory index and hyperuricemia: a mediation analysis based on NHANES (2007–2016)
He, Q., Zheng, Q., Diao, H., Li, M., Zhu, Q., Fang, F., & Cui, W. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01418-x · Cited by 3
Association between dietary insulin index and load with brain derived neurotrophic factor, adropin and metabolic health status in Iranian adults
Nematbakhsh, R., Hajhashemy, Z., Lotfi, K., Shahdadian, F., Rouhani, P., & Saneei, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-48056-x · Cited by 3
Physical Activity and Inflammation
Fenza, R. D., & Fiorina, P. (2012) · Springer eBooks · doi:10.1007/978-88-470-2418-2_10 · Cited by 3
Paraneoplastic Syndromes in Pancreatic Cancer
Werner, J., & Herzig, S. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7193-0_27 · Cited by 3
Paraneoplastic Syndromes in Pancreatic Cancer
Werner, J., & Herzig, S. (2009) · Springer eBooks · doi:10.1007/978-0-387-77498-5_27 · Cited by 3
Restoration of pro-inflammatory cytokines and histopathological changes in pancreas and liver of hyperglycemic rats by Murraya koenigii leaves extract
Husna, F., Suyatna, F. D., Arozal, W., Purwaningsih, E. H., & Sani, Y. (2020) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2020.101002 · Cited by 3
The Associations between Erythropoietic Response with Inflammation Markers and Perfluorinated Chemicals in Hemodialysis Patients
Liu, W., Lin, C.-H., Tan, A. C., Lai, Y., Liu, T., Chan, H., Li, S., Chen, C.-F., Chen, Y., Chen, T., et al. (2023) · Healthcare · doi:10.3390/healthcare11030442 · Cited by 3
Type 1 Diabetes and Beta Cells
Owens-Collins, S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1001513 · Cited by 3
Metabolic Syndrome in Humans and Horses: The Relationship Between Obesity and Insulin Resistance
Burns, T., & Toribio, R. (2016) · doi:10.1002/9781119169239.ch18 · Cited by 3
Free triiodothyronine and triglyceride-glucose index interaction on metabolic dysfunction-associated steatotic liver disease risk in euthyroid individuals
Gao, L., Cui, W., Pan, F., Mu, D., Zhou, W., & Hu, Y. F. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1526198 · Cited by 2
A randomised controlled trial of short-term Intermittent Energy Restriction [IER] versus Continuous Energy Restriction [CER] on body fat stores and measures of insulin resistance in women with obesity at increased risk of breast cancer
Harvie, M., Coe, P. O., Higham, C., Peach, N., Howell, A., Evans, D. G., Williams, S., Sellers, K., Malcomson, L., Pegington, M., et al. (2025) · BMC Nutrition · doi:10.1186/s40795-025-01181-4 · Cited by 2
Brain insulin resistance as an early target to attenuate neuroinflammation, oxidative stress and proteinopathies in Alzheimer’s disease: A systematic review of five natural products
Mohamed, R. A., Abdelaziz, R. H., Mohamed, M. S., Ahmed, N. H., & Ahmed, R. M. (2025) · Next research. · doi:10.1016/j.nexres.2025.100979 · Cited by 7
Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response
Lê, S., Sturaro, E., Thomas, C., Canceill, T., Ekambi, B., Fellouah, N., Knauf, C., Abot, A., Tenailleau, C., Duployer, B., et al. (2025) · International Journal of Oral Science · doi:10.1038/s41368-025-00403-6 · Cited by 3
Gestational Diabetes Mellitus and Future Risk of Cardiovascular Disease
Bhake, R. C., Chittake, V., Lumpatki, S. B., Tiwari, S., & Unnikrishnan, A. G. (2025) · Chronicle of Diabetes Research and Practice · doi:10.4103/cdrp.cdrp_12_25 · Cited by 2
Powder bergamot juice attenuates skeletal muscle complications in an experimental model of metabolic syndrome
Sormani, L. E., Cruzeiro, J., Belin, M. A. F., dos Santos, M. D. P. S., Siqueira, J. S. [., Vieira, T. A., Grandini, N. A., Tanganini, M. D., Palacio, T. L. N., Romualdo, G. R., et al. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112828 · Cited by 2
Nutrition, Diabetes, and Cancer
LaValle, J. B. (2008) · Frontiers in diabetes · doi:10.1159/000152029 · Cited by 2
Comprehensive analysis of circulating miRNA expression profiles in insulin resistance and type 2 diabetes in Qatari population
Errafii‬, K., Jayyous, A., Arredouani, A., Khatib, H., Azizi, F., Mohammad, R. M., Abdul‐Ghani, M. A., & Chikri, M. (2022) · All Life · doi:10.1080/26895293.2022.2033853 · Cited by 2

Authors: de Luca, C., & Olefsky, J. M.
Affiliations: University of California San Diego (US)
Corresponding author: Olefsky, Jerrold M.
ORCID: Olefsky, Jerrold M.
Venue: FEBS Letters
Publisher: Wiley
Published: 2007-11-29
Volume: 582
Issue: 1
Pages: 97-105
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2007.11.057
PMC: PMC2246086
OpenAlex: W2031882974
Cited by: 1,161
References: 66
Citations by year: 2026: 56 · 2025: 68 · 2024: 54 · 2023: 83 · 2022: 82 · 2021: 83 · 2020: 68 · 2019: 64 · 2018: 73 · 2017: 69 · 2016: 58 · 2015: 56 · 2014: 40 · 2013: 65 · 2012: 58
FWCI: 5.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 074868, DK 033651, T32DK007494, R37DK033651, DK007494, P01DK074868)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD012303)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: insulin resistance, obesity, chronic inflammation, metabolic syndrome, inflammatory cytokines, adipose tissue, skeletal muscle, liver, insulin signaling, macrophages, autocrine and paracrine signaling
MeSH terms: Humans, Inflammation, Insulin Resistance, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation and insulin resistance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks