Cited by 1,161Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Inflammation and insulin resistance

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de Luca, Carl, Olefsky, Jerrold M.·2008·FEBS Letters

DOI 10.1016/j.febslet.2007.11.057PMC PMC2246086

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Abstract

Obesity‐induced chronic inflammation is a key component in the pathogenesis of insulin resistance and the Metabolic syndrome. In this review, we focus on the interconnection between obesity, inflammation and insulin resistance. Pro‐inflammatory cytokines can cause insulin resistance in adipose tissue, skeletal muscle and liver by inhibiting insulin signal transduction. The sources of cytokines in insulin resistant states are the insulin target tissue themselves, primarily fat and liver, but to a larger extent the activated tissue resident macrophages. While the initiating factors of this inflammatory response remain to be fully determined, chronic inflammation in these tissues could cause localized insulin resistance via autocrine/paracrine cytokine signaling and systemic insulin resistance via endocrine cytokine signaling all of which contribute to the abnormal metabolic state.

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Authors: de Luca, C., & Olefsky, J. M.
Affiliations: University of California San Diego (US)
Corresponding author: Olefsky, Jerrold M.
ORCID: Olefsky, Jerrold M.
Venue: FEBS Letters
Publisher: Wiley
Published: 2007-11-29
Volume: 582
Issue: 1
Pages: 97-105
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2007.11.057
PMC: PMC2246086
OpenAlex: W2031882974
Cited by: 1,161
References: 66
Citations by year: 2026: 56 · 2025: 68 · 2024: 54 · 2023: 83 · 2022: 82 · 2021: 83 · 2020: 68 · 2019: 64 · 2018: 73 · 2017: 69 · 2016: 58 · 2015: 56 · 2014: 40 · 2013: 65 · 2012: 58
FWCI: 5.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK 074868, DK 033651, T32DK007494, R37DK033651, DK007494, P01DK074868)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD012303)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: insulin resistance, obesity, chronic inflammation, metabolic syndrome, inflammatory cytokines, adipose tissue, skeletal muscle, liver, insulin signaling, macrophages, autocrine and paracrine signaling
MeSH terms: Humans, Inflammation, Insulin Resistance, Signal Transduction

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