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Cited by 203

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR–RXR complex

Ziouzenkova, Ouliana, Plutzky, Jorge·2008·FEBS Letters
DOI 10.1016/j.febslet.2007.11.081
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Abstract

Retinoids, naturally‐occurring vitamin A derivatives, regulate metabolism by activating specific nuclear receptors, including the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). RXR, an obligate heterodimeric partner for other nuclear receptors, including peroxisome proliferator‐activated receptors (PPARs), helps coordinate energy balance. Recently, many groups have identified new connections between retinoid metabolism and PPAR responses. We found that retinaldehyde (Rald), a molecule that can yield RA through the action of retinaldehyde dehydrogenases (Raldh), is present in fat in vivo and can inhibit PPARγ‐induced adipogenesis. In vitro, Rald inhibits RXR and PPARγ activation. Raldh1‐deficient mice have increased Rald levels in fat, higher metabolic rates and body temperatures, and are protected against diet‐induced obesity and insulin resistance. Interestingly, one specific asymmetric β‐carotene cleavage product, apo‐14′‐carotenal, can also inhibit PPARγ and PPARα responses. These data highlight how pathways of β‐carotene metabolism and specific retinoid metabolites may have direct distinct metabolic effects.

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Metadata

Authors
Ziouzenkova, O., & Plutzky, J.
Venue
FEBS Letters
Publisher
Wiley
Published
2007-12-07
Volume
582
Issue
1
Pages
32-38
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/j.febslet.2007.11.081
OpenAlex
W2048732925
Cited by
203
References
10
FWCI
5.51
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR–RXR complex. https://app.cochat.ai/papers/10.1016/j.febslet.2007.11.081
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Ziouzenkova, O., & Plutzky, J. (2008). Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR–RXR complex. FEBS Letters. https://doi.org/10.1016/j.febslet.2007.11.081

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.