The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
PPARγ in adipocyte differentiation and metabolism – Novel insights from genome‐wide studies
Abstract
Adipocyte differentiation is controlled by a tightly regulated transcriptional cascade in which PPARγ and members of the C/EBP family are key players. Here we review the roles of PPARγ and C/EBPs in adipocyte differentiation with emphasis on the recently published genome‐wide binding profiles for PPARγ and C/EBPα. Interestingly, these analyses show that PPARγ and C/EBPα binding sites are associated with most genes that are induced during adipogenesis suggesting direct activation of many more adipocyte genes than previously anticipated. Furthermore, an extensive overlap between the C/EBPα and PPARγ cistromes indicate a hitherto unrecognized direct crosstalk between these transcription factors. As more genome‐wide data emerge in the future, this crosstalk will likely be found to include several other adipogenic transcription factors.
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Cited by
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology
Shimano, H., & Sato, R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.91 · Cited by 1,174
The Short-Chain Fatty Acid Acetate in Body Weight Control and Insulin Sensitivity
González Hernández, M. A., Canfora, E. E., Jocken, J. W. E., & Blaak, E. E. (2019) · Nutrients · doi:10.3390/nu11081943 · Cited by 624
PPARγ and the global map of adipogenesis and beyond
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Self-citationQiao, Y., Sun, J., Xia, S., Tang, X., Shi, Y., & Le, G. (2014) · Food & Function · doi:10.1039/c3fo60630a · Cited by 367
Metadata
- Authors
- Siersbæk, R., Nielsen, R., & Mandrup, S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-06-11
- Volume
- 584
- Issue
- 15
- Pages
- 3242-3249
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2097544331
- Cited by
- 400
- References
- 90
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- closed
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