The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
MALAT‐1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility‐related genes
Open accessAbstract
MALAT‐1, a long non‐coding RNA, is associated with metastasis, but its role in the metastatic process remains unknown. Here, we show that short‐interfering RNA‐mediated MALAT‐1 silencing impaired in vitro cell motility of lung cancer cells and influenced the expression of numerous genes. In these genes, knockdown of any one of CTHRC1, CCT4, HMMR, or ROD1 clearly inhibited cell migration. In MALAT‐1 knockdown cells, pre‐mRNA levels were decreased in some but not all genes. Thus, our findings suggest that MALAT‐1 is a novel class of non‐coding RNA that promotes cell motility through transcriptional and post‐transcriptional regulation of motility related gene expression.
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Cites
Long non-coding RNAs: insights into functions
Mercer, T. R., Dinger, M. E., & Mattick, J. S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2521 · Cited by 5,654
The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686 · cited 1×
“Introduction Metastasis is the major cause of mortality in patients with solid tumors [1].”
BackgroundThe t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo
Sternlicht, H., Farr, G. W., Sternlicht, M. L., Driscoll, J. K., Willison, K., & Yaffe, M. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9422 · Cited by 341
Cited by
Long noncoding RNAs: past, present, and future
Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
Gutschner, T., Hämmerle, M., Eißmann, M., Hsu, J., Kim, Y., Hung, G., Revenko, A., Arun, G., Stentrup, M., Groß, M., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2850 · Cited by 1,415
Okugawa, Y., Toiyama, Y., Hur, K., Toden, S., Saigusa, S., Tanaka, K., Inoue, Y., Mohri, Y., Kusunoki, M., Boland, C. R., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu200 · Cited by 213
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LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21
Zhou, X., Yuan, P., Liu, Q., & Liu, Z. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.162 · Cited by 78
An Emerging Role for Long Non-Coding RNA Dysregulation in Neurological Disorders
Fenoglio, C., Ridolfi, E., Galimberti, D., & Scarpini, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020427 · Cited by 68
MALAT1: A long non‑coding RNA highly associated with human cancers (Review)
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Metadata
- Authors
- Tano, K., Mizuno, R., Okada, T., Rakwal, R., Shibato, J., Masuo, Y., Ijiri, K., & Akimitsu, N.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-10-10
- Volume
- 584
- Issue
- 22
- Pages
- 4575-4580
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2015704257
- Cited by
- 424
- References
- 3
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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