Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice
Open accessAbstract
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with testosterone increased the expression level of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α), ATP5B and Cox4 in skeletal muscle, but not that in brown adipose tissue and liver. mRNA levels of genes involved in mitochondrial biogenesis were elevated in skeletal muscle isolated from testosterone-treated male mice, but were down-regulated in androgen receptor deficient mice. These results demonstrated that the testosterone-induced increase in energy expenditure is derived from elevated mitochondrial biogenesis in skeletal muscle.
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Mice treated with exogenous testosterone have transcriptionally upregulated mitochondrial biogenesis.
“Corroborating this, mice that are treated with exogenous T have transcriptionally upregulated mitochondrial biogenesis.131”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [131]
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- Authors
- Usui, T., Kajita, K., Kajita, T., Mori, I., Hanamoto, T., Ikeda, T., Okada, H., Taguchi, K., Kitada, Y., Morita, H., Sasaki, T., Kitamura, T., Sato, T., Kojima, I., & Ishizuka, T.
- Affiliations
- Gifu University (JP)
- Gunma University (JP)
- Corresponding author
- Ishizuka, Tatsuo
- ORCID
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2014-04-12
- Volume
- 588
- Issue
- 10
- Pages
- 1935-1941
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2109259286
- Cited by
- 100
- References
- 29
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 15 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 8
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Gifu University Institutional Repository (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- testosterone, mitochondrial biogenesis, skeletal muscle, androgens, energy expenditure, thermogenesis, PGC-1α, ATP5B, COX4, androgen receptor, weight loss, fat mass reduction, brown adipose tissue
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Androgens, Animals, Blood Glucose, Body Weight, Cell Line, DNA, Mitochondrial, Eating, Energy Metabolism, Male, Mice, Inbred C57BL, Mitochondria, Muscle, Myoglobin, Receptors, Androgen, Testosterone, Transcription Factors, Troponin, Blotting, Western, Weight Loss, Mice, Knockout, Muscle, Skeletal, Muscle Fibers, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Cytochromes c, Nuclear Respiratory Factor 1, Mice
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