Cited by 100Adipose Tissue and MetabolismMitochondrial Function and PathologyMuscle Physiology and Disorders

Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone-induced body weight loss in male mice

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Usui, Taro, Kajita, Kazuo, Kajita, Toshiko, Mori, Ichiro, Hanamoto, Takayuki, Ikeda, Takahide, Okada, Hideyuki, Taguchi, Koichiro +7 more·2014·FEBS Letters

Abstract

Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with testosterone increased the expression level of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α), ATP5B and Cox4 in skeletal muscle, but not that in brown adipose tissue and liver. mRNA levels of genes involved in mitochondrial biogenesis were elevated in skeletal muscle isolated from testosterone-treated male mice, but were down-regulated in androgen receptor deficient mice. These results demonstrated that the testosterone-induced increase in energy expenditure is derived from elevated mitochondrial biogenesis in skeletal muscle.

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Crossref · 10.1016/j.febslet.2014.03.051

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Authors
Usui, T., Kajita, K., Kajita, T., Mori, I., Hanamoto, T., Ikeda, T., Okada, H., Taguchi, K., Kitada, Y., Morita, H., Sasaki, T., Kitamura, T., Sato, T., Kojima, I., & Ishizuka, T.
Affiliations
  • Gifu University (JP)
  • Gunma University (JP)
Corresponding author
Ishizuka, Tatsuo
Venue
FEBS Letters
Publisher
Wiley
Published
2014-04-12
Volume
588
Issue
10
Pages
1935-1941
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2109259286
Cited by
100
References
29
Citations by year
2026: 9 · 2025: 3 · 2024: 15 · 2023: 8 · 2022: 11 · 2021: 6 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 8
FWCI
5.55
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Gifu University Institutional Repository (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
testosterone, mitochondrial biogenesis, skeletal muscle, androgens, energy expenditure, thermogenesis, PGC-1α, ATP5B, COX4, androgen receptor, weight loss, fat mass reduction, brown adipose tissue
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Androgens, Animals, Blood Glucose, Body Weight, Cell Line, DNA, Mitochondrial, Eating, Energy Metabolism, Male, Mice, Inbred C57BL, Mitochondria, Muscle, Myoglobin, Receptors, Androgen, Testosterone, Transcription Factors, Troponin, Blotting, Western, Weight Loss, Mice, Knockout, Muscle, Skeletal, Muscle Fibers, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Cytochromes c, Nuclear Respiratory Factor 1, Mice

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