The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Pyruvate kinase M2 and cancer: an updated assessment
Abstract
Cancer cells are characterized by high glycolytic rates to support energy regeneration and anabolic metabolism, along with the expression of pyruvate kinase isoenzyme M2 (PKM2). The latter catalyzes the last step of glycolysis and reprograms the glycolytic flux to feed the special metabolic demands of proliferating cells. Besides, PKM2 has moonlight functions, such as gene transcription, favoring cancer. Accumulating evidence suggests a critical role played by the low‐activity‐dimeric PKM2 in tumor progression, supported by the identification of mutations which result in the down‐regulation of its activity and tumorigenesis in a nude mouse model. This review discusses PKM2 regulation and the benefits it confers to cancer cells. Further, conflicting views on PKM2's role in cancer, its therapeutic relevance and future directions in the field are also discussed.
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Cites
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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
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BackgroundCycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
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PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
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Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
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�ber den Stoffwechsel der Carcinomzelle
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Cited by
Revisiting the Warburg effect: historical dogma versus current understanding
Vaupel, P., & Multhoff, G. (2021) · The Journal of Physiology · doi:10.1113/jp278810 · Cited by 830
PKM2, function and expression and regulation
Zhang, Z., Deng, X., Liu, Y., Liu, Y., Sun, L., & Chen, F. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0317-8 · Cited by 498
The Warburg Effect 97 Years after Its Discovery
Pascale, R. M., Calvisi, D. F., Simile, M. M., Feo, C. F., & Feo, F. (2020) · Cancers · doi:10.3390/cancers12102819 · Cited by 300
Metabolic dysregulation in monogenic disorders and cancer — finding method in madness
Erez, A., & DeBerardinis, R. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3949 · Cited by 105
Mamczur, P., Borsuk, B., Paszko, J., Sas, Z., Mozrzymas, J., Wiśniewski, J. R., Gizak, A., & Rakus, D. (2015) · Glia · doi:10.1002/glia.22753 · Cited by 71
Metadata
- Authors
- Iqbal, M. A., Gupta, V., Gopinath, P., Mazurek, S., & Bamezai, R. N. K.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2014-04-18
- Volume
- 588
- Issue
- 16
- Pages
- 2685-2692
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1976093153
- Cited by
- 189
- References
- 12
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- closed
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