Metabolic dysregulation in monogenic disorders and cancer — finding method in madness

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Hepatocellular Carcinoma in Type 1 Gaucher Disease: A Case Report with Review of the Literature

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New Advances in the Genetics of Pheochromocytoma and Paraganglioma Syndromes

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Gaucher disease, enzyme replacement therapy, and the Patient Assistance Program.

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Fundamentals of Cancer Metabolism

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Understanding the Intersections between Metabolism and Cancer Biology

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METTL3-mediated m 6 A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

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Regulation and function of the mammalian tricarboxylic acid cycle

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Metabolic signatures of cancer cells and stem cells

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Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

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Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer

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Targeting Metabolic–Redox Circuits for Cancer Therapy

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Drugging the addict: non‐oncogene addiction as a target for cancer therapy

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A chemoproteomic portrait of the oncometabolite fumarate

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Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer

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Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

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Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma

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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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The context-specific roles of urea cycle enzymes in tumorigenesis

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Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

Fernández-Gil, B. I., Guerra‐Librero, A., Shen, Y., Florido, J., Martínez-Ruiz, L., García-López, S., Adan, C., Rodríguez-Santana, C., Acuña-Castroviejo, D., Quiñones‐Hinojosa, A., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7187128 · Cited by 92 · see citing works

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

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The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat

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On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer

Penkert, J., Ripperger, T., Schieck, M., Schlegelberger, B., Steinemann, D., & Illig, T. (2016) · Oncotarget · doi:10.18632/oncotarget.11759 · Cited by 62 · see citing works

GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone

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Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy

Chen, C., Wang, Z., & Qin, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.935536 · Cited by 60 · see citing works

Metabolomics and lipidomics strategies in modern drug discovery and development

Astarita, G., Kelly, R. S., & Lasky-Su, J. A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103751 · Cited by 59 · see citing works

Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment

Mikkilineni, L., Whitaker‐Menezes, D., Domingo‐Vidal, M., Sprandio, J. D., Avena, P., Cotzia, P., Dulau‐Florea, A., Gong, J. Z., Uppal, G. K., Zhan, T., et al. (2017) · Seminars in Oncology · doi:10.1053/j.seminoncol.2017.10.003 · Cited by 55 · see citing works

Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4

Jia, W., Zhao, X., Zhao, L., Yan, H., Li, J., Yang, H., Huang, G., & Liu, J. (2018) · Oncogene · doi:10.1038/s41388-017-0072-4 · Cited by 54 · see citing works

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy

long, Y. N., Tsai, W.-B., Wang, D., Hawke, D. H., Savaraj, N., Feun, L. G., Hung, M., Chen, H. H. W., & Kuo, M. T. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.11.028 · Cited by 51 · see citing works

The role of metabolic ecosystem in cancer progression — metabolic plasticity and mTOR hyperactivity in tumor tissues

Sebestyén, A. R., Dankó, T., Sztankovics, D., Moldvai, D., Raffay, R. E., Cervi, C., Krencz, I., Zsiros, V., Jeney, A., & Petővári, G. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10006-2 · Cited by 46 · see citing works

Rescue of TCA Cycle Dysfunction for Cancer Therapy

Marquez, J. C., Flores, J., Kim, A. H., Nyamaa, B., Nguyen, A. T. T., Park, N., & Han, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122161 · Cited by 46 · see citing works

Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy

Kumar, R., Mishra, A., Gautam, P., Feroz, Z., Vijayaraghavalu, S., Likos, E., Shukla, G. C., & Kumar, M. (2022) · Cancers · doi:10.3390/cancers14215268 · Cited by 48 · see citing works

Coumarin carboxylic acids as monocarboxylate transporter 1 inhibitors: In vitro and in vivo studies as potential anticancer agents

Jonnalagadda, S., Jonnalagadda, S. K., Alam, M. A., Ronayne, C. T., Nelson, G. L., Solano, L. N., Lueth, E. A., Drewes, L. R., & Mereddy, V. R. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.05.054 · Cited by 43 · see citing works

PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA

Shi, L., An, S., Liu, Y., Liu, J., & Wang, F. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s241717 · Cited by 45 · see citing works

ASS1 and ASL suppress growth in clear cell renal cell carcinoma via altered nitrogen metabolism

Khare, S., Kim, L. C., Lobel, G. P., Doulias, P., Ischiropoulos, H., Nissim, I., Keith, B., & Simon, M. C. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00271-8 · Cited by 43 · see citing works

The KEAP1–NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis

Ong, A. J. S., Bladen, C. E., Tigani, T. A., Karamalakis, A. P., Evason, K. J., Brown, K., & Cox, A. G. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217425120 · Cited by 43 · see citing works

Colorectal cancer and therapy response: a focus on the main mechanisms involved

Tirendi, S., Marengo, B., Domenicotti, C., Bassi, A. M., Almonti, V., & Vernazza, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1208140 · Cited by 35 · see citing works

A metabolic link between the urea cycle and cancer cell proliferation

Nagamani, S. C. S., & Erez, A. (2016) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1127314 · Cited by 36 · see citing works

Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer

Wu, H. J., Xian, Y., Zhang, S., Wang, X., Jin, Q., & Wang, W. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s105787 · Cited by 36 · see citing works

PKM2 Is the Target of a Multi-Herb-Combined Decoction During the Inhibition of Gastric Cancer Progression

Sun, Q., Yuan, M., Wang, H., Zhang, X., Zhang, R., Wang, H., Chen, X., Zhu, M., Liu, S., & Wu, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.767116 · Cited by 35 · see citing works

Seeding of proteins into amyloid structures by metabolite assemblies may clarify certain unexplained epidemiological associations

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TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis

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ASL Metabolically Regulates Tyrosine Hydroxylase in the Nucleus Locus Coeruleus

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Redox-Responsive MRI Probes Based on First-Row Transition-Metal Complexes

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Liver neoplasms in methylmalonic aciduria: An emerging complication

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Early Infiltration of Innate Immune Cells to the Liver Depletes HNF4α and Promotes Extrahepatic Carcinogenesis

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Co-opting a Bioorthogonal Reaction for Oncometabolite Detection

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Nanozymes in cancer immunotherapy: metabolic disruption and therapeutic synergy

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