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Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain
Open accessAbstract
Objective To compare the efficacy and safety of SC depot medroxyprogesterone acetate (DMPA-SC 104) with that of leuprolide acetate in treatment of endometriosis.Design Phase 3, multicenter, randomized, evaluator-blinded, comparator-controlled trial.Setting Clinical trial sites in Canada and United States.Patient(s) Two hundred seventy-four women with surgically diagnosed endometriosis.Intervention(s) Intramuscular injections of DMPA-SC (104 mg) or leuprolide acetate (11.25 mg), given every 3 months for 6 months, with 12 months of posttreatment follow-up.Main outcome measure(s) Reduction in five endometriosis symptoms or signs (dysmenorrhea, dyspareunia, pelvic pain, pelvic tenderness, pelvic induration); change in bone mineral density (BMD), hypoestrogenic symptoms, bleeding, and weight.Result(s) The depot medroxyprogesterone acetate given SC was statistically equivalent to leuprolide in reducing four of five endometriosis symptoms or signs at the end of treatment (month 6) and in reducing all five symptoms after 12 months' follow-up (month 18). Patients in the DMPA-SC 104 group showed significantly less BMD loss than did leuprolide patients at month 6, with scores returning to baseline at 12 months' follow-up. No statistically significant differences in median weight changes were observed between groups. Compared with leuprolide, DMPA-SC 104 was associated with fewer hypoestrogenic symptoms but more irregular bleeding.Conclusion(s) Efficacy of DMPA-SC 104 was equivalent to that of leuprolide for reducing endometriosis-associated pain, with less impact on BMD and fewer hypoestrogenic side effects but more bleeding.
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In the citing paper
“Depot medroxyprogesterone acetate (MPA; 104 mg, subcutaneous injection, every 3 months) has demonstrated an efficacy equivalent to LA, but long-term use of depot MPA preparations is shown to impact adversely on bone mineral density (BMD), while the delay in resumption of ovulation that may follow discontinuation of this therapy is a contraindication to use in women wishing to conceive in the near”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Schlaff et al., 2006
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“MPA appeared to be more effective than placebo [214] and as effective as danazol [215] and GnRH-agonists [216, 217] in reducing endometriosis-related pain.”
From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [217]
The cited source says what the claim attributes to it.
In the citing paper
“Irregular uterine bleeding is a known adverse effect of treatment with progestins, including depot preparations of MPA, which have been compared in trials against LA (Vercellini et al., 2003;Crosignani et al., 2006;Schlaff et al., 2006).”
From Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial (2010) · cites this paper as Schlaff et al., 2006
In the citing paper
“In both studies DMPA-SC was statistically equivalent to GnRHa in reducing pain symptoms after 12 months' follow-up.”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [51]
In the citing paper
“Patients in the DMPA-SC group showed significantly less BMD loss than did leuprolide patients at month 6.”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [51]
In the citing paper
“Progestins were positively associated with HRQoL in women with endometriosis [20,21,23-25,27,29,30].”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [25]
In the citing paper
“Six months of GnRHa treatment improved women’s HRQoL even at one year after treatment, according to the SF-36 questionnaire [24-27,29], as well as work-related indexes [18,20].”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [25]
In the citing paper
“Moreover, six months of therapy with progestins seemed equivalent to that of GnRHa in improving HRQoL and reducing pain, according to six RCTs [20,23-25,27,29].”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [25]
In the citing paper
“Subcutaneous injections of depomedroxyprogesterone acetate (104 mg/0.65 mL) improved all pre-specified scales of the EHP-30 and SF-36 from baseline to the end of the 6-month treatment and even at the 18-month follow-up [24,25].”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [25]
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Citations
Cites
1 retracted
Friedman, A. J., & Hornstein, M. D. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56090-7 · Cited by 47
RetractedDlugi, A. M., Miller, J. D., & Knittle, J. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53755-8 · Cited by 279
Leuprolide Acetate Depot and Hormonal Add-Back in Endometriosis: A 12-Month Study
Hornstein, M. D. (1998) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00620-0 · Cited by 244
Progestins for symptomatic endometriosis: a critical analysis of the evidence
Vercellini, P., Cortesi, I., & Crosignani, P. G. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00193-3 · Cited by 229
Contraceptive efficacy and safety of DMPA-SC
Jain, J. K., Jakimiuk, A. J., Bode, F. R., Ross, D., & Kaunitz, A. M. (2004) · Contraception · doi:10.1016/j.contraception.2004.06.011 · Cited by 178
Self-citationSchwallie, P. C., & Assenzo, J. R. (1973) · Fertility and Sterility · doi:10.1016/s0015-0282(16)39669-8 · Cited by 167
Cosson, M., Querleu, D., Donnez, J., Madelenat, P., Konincks, P., Audebert, A., & Manhes, H. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03270-8 · Cited by 153
Endometriosis: Treatment Strategies
VALLE, R. F., & Sciarra, J. J. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1290.026 · Cited by 151
Westhoff, C. L. (2003) · Contraception · doi:10.1016/s0010-7824(03)00136-7 · Cited by 146
Lockhat, F. B. (2004) · Human Reproduction · doi:10.1093/humrep/deh004 · Cited by 135
Cited by
Sorted by citations
Consensus on current management of endometriosis
Johnson, N. P., Hummelshoj, L., for the World Endometriosis Society Montpellier Consortium, Abrao, M. S., Adamson, G. D., Allaire, C., Amelung, V., Andersson, E., Becker, C., Birna Árdal, K. B., et al. (2013) · Human Reproduction · doi:10.1093/humrep/det050 · Cited by 558
Strowitzki, T., Marr, J., Gerlinger, C., Faustmann, T., & Seitz, C. (2010) · Human Reproduction · doi:10.1093/humrep/dep469 · Cited by 381
Systematic review of endometriosis pain assessment: how to choose a scale?
Bourdel, N., Alves, J., Pickering, G. P., Ramilo, I. D. T. M., Roman, H., & Canis, M. J. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu046 · Cited by 378
Hormonal treatments for endometriosis: The endocrine background
Vannuccini, S., Clemenza, S., Rossi, M., & Petraglia, F. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09666-w · Cited by 336
Reevaluating response and failure of medical treatment of endometriosis: a systematic review
Becker, C. M., Gattrell, W. T., Gude, K., & Singh, S. S. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.004 · Cited by 302
Progestagens and anti-progestagens for pain associated with endometriosis
Brown, J., Kives, S., & Akhtar, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002122.pub2 · Cited by 250
Estrogen-progestins and progestins for the management of endometriosis
Vercellini, P., Buggio, L., Berlanda, N., Barbara, G., Somigliana, E., & Bosari, S. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.10.022 · Cited by 243
Endometriosis: The Role of Neuroangiogenesis
Asante, A., & Taylor, R. N. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142158 · Cited by 223
Medical treatment of endometriosis-related pain
Vercellini, P., Buggio, L., Frattaruolo, M. P., Borghi, A., Dridi, D., & Somigliana, E. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.015 · Cited by 188
Non-contraceptive benefits of hormonal and intrauterine reversible contraceptive methods
Bahamondes, L. G., Bahamondes, M. V., & SHULMAN, L. P. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv023 · Cited by 196
Endometriosis: Current Therapies and New Pharmacological Developments
Vercellini, P., Somigliana, E., Viganò, P., Abbiati, A., Barbara, G., & Crosignani, P. G. (2009) · Drugs · doi:10.2165/00003495-200969060-00002 · Cited by 182
“Waiting for Godot”: a commonsense approach to the medical treatment of endometriosis
Vercellini, P., Crosignani, P., Somigliana, E., Vigano, P., Frattaruolo, M. P., & Fedele, L. (2011) · Human Reproduction · doi:10.1093/humrep/deq302 · Cited by 180
“…GnRH agonists and aromatase inhibitors (Vercellini et al., 1993, 1996; Prentice et al., 2000, 2004; Cosson et al., 2002; Petta et al., 2005; Schlaff et al., 2006; Crosignani et al., 2006b; Davis et al., 2007; Selak et al., 2007; Harada et al., 2009; Ferrero et al., 2009b; Strowitzki et…”
BackgroundPharmacologic therapies in endometriosis: a systematic review
Soares, S. R., Martínez‐Varea, A., Hidalgo‐Mora, J. J., & Pellicer, A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.07.1120 · Cited by 154
Current and emerging treatment options for endometriosis
Ferrero, S., Evangelisti, G., & Barra, F. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1494154 · Cited by 152
Bone density recovery after depot medroxyprogesterone acetate injectable contraception use
Kaunitz, A. M., Arias, R., & McClung, M. R. (2008) · Contraception · doi:10.1016/j.contraception.2007.10.005 · Cited by 148
Gerlinger, C., Schumacher, U., Faustmann, T. A., Colligs, A., Schmitz, H., & Seitz, C. (2010) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-8-138 · Cited by 135
Endometriosis: current and future medical therapies
Vercellini, P., Somigliana, E., Viganò, P., Abbiati, A., Daguati, R., & Crosignani, P. G. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.10.001 · Cited by 136
Health-related quality of life in women with endometriosis: a systematic review
Jia, S.-Z., Leng, J.-H., Shi, J.-H., Sun, P.-R., & Lang, J.-H. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-29 · Cited by 132
“Moreover, six months of therapy with progestins seemed equivalent to that of GnRHa in improving HRQoL and reducing pain, according to six RCTs [20,23-25,27,29].”
BackgroundMethodInfluentialCurrent and Emerging Therapeutics for the Management of Endometriosis
Ferrero, S., Barra, F., & Maggiore, U. L. R. (2018) · Drugs · doi:10.1007/s40265-018-0928-0 · Cited by 135
Walch, K., Unfried, G., Huber, J., Kurz, C., van Trotsenburg, M., Pernicka, E., & Wenzl, R. (2009) · Contraception · doi:10.1016/j.contraception.2008.07.017 · Cited by 128
Treatment of pain associated with deep endometriosis: alternatives and evidence
Ferrero, S., Alessandri, F., Racca, A., & Maggiore, U. L. R. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.031 · Cited by 124
Diamond, M. P., Carr, B. R., Dmowski, W. P., Koltun, W. D., O'Brien, C. F., Jiang, P. X., Burke, J., Jimenez, R., Garner, E. I. O., & Chwalisż, K. (2013) · Reproductive Sciences · doi:10.1177/1933719113497292 · Cited by 121
Carr, B., Dmowski, W. P., O’Brien, C., Jiang, P., Burke, J., Jimenez, R., Garner, E., & Chwalisz, K. (2014) · Reproductive Sciences · doi:10.1177/1933719114549848 · Cited by 114
Kulak, J., Fischer, C., Komm, B., & Taylor, H. S. (2011) · Endocrinology · doi:10.1210/en.2010-1010 · Cited by 112
Diagnosis and treatment of bladder endometriosis: state of the art
Maccagnano, C., Pellucchi, F., Rocchini, L., Ghezzi, M., Scattoni, V., Montorsi, F., Rigatti, P., & Colombo, R. (2012) · Urologia Internationalis · doi:10.1159/000339519 · Cited by 112
Barra, F., Scala, C., & Ferrero, S. (2018) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1461840 · Cited by 100
Maccagnano, C., Pellucchi, F., Rocchini, L., Ghezzi, M., Scattoni, V., Montorsi, F., Rigatti, P., & Colombo, R. (2013) · Urologia Internationalis · doi:10.1159/000345140 · Cited by 100
Deep dyspareunia and sex life after laparoscopic excision of endometriosis
Ferrero, S., Abbamonte, L. H., Giordano, M., Ragni, N., & Remorgida, V. (2006) · Human Reproduction · doi:10.1093/humrep/del465 · Cited by 98
Hormonal therapy for endometriosis: from molecular research to bedside
Tosti, C., Biscione, A., Morgante, G., Bifulco, G., Luisi, S., & Petraglia, F. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.05.032 · Cited by 96
Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.074 · Cited by 85
WONG, A. Y. K., TANG, L. C. H., & CHIN, R. K. H. (2010) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2010.01152.x · Cited by 82
Validation of the SF-36 in patients with endometriosis
Stull, D. E., Wasiak, R., Kreif, N., Raluy, M., Colligs, A., Seitz, C., & Gerlinger, C. (2013) · Quality of Life Research · doi:10.1007/s11136-013-0442-5 · Cited by 77
Treatment strategies for endometriosis
Rodgers, A. K., & Falcone, T. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.2.243 · Cited by 72
A comprehensive review of hormonal and biological therapies for endometriosis: latest developments
Barra, F., Grandi, G., Tantari, M., Scala, C., Facchinetti, F., & Ferrero, S. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1581761 · Cited by 69
Sansone, A., Rosa, N. D., Giampaolino, P., Guida, M., Laganà, A. S., & Carlo, C. D. (2018) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-018-4851-0 · Cited by 68
Katayama, H., Katayama, T., Uematsu, K., Hiratsuka, M., Kiyomura, M., Shimizu, Y., Sugita, A., & Ito, M. (2010) · Human Reproduction · doi:10.1093/humrep/deq241 · Cited by 68
Mönckedieck, V., Sannecke, C., Husen, B., Kumbartski, M., Kimmig, R., Tötsch, M., Winterhager, E., & Grümmer, R. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap063 · Cited by 65
Elagolix, an Oral GnRH Antagonist for Endometriosis-Associated Pain: A Randomized Controlled Study
Carr, B. R., Giudice, L. C., Dmowski, W. P., O’Brien, C., Jiang, P. X., Burke, J., Jimenez, R., Hass, S., Fuldeore, M. J., & Chwalisż, K. (2013) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000157 · Cited by 64
Current pharmacotherapy for endometriosis
Ferrero, S., Remorgida, V., & Venturini, P. L. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656561003685880 · Cited by 60
Oral and depot progestin therapy for endometriosis: towards a personalized medicine
Buggio, L., Somigliana, E., Barbara, G., Frattaruolo, M. P., & Vercellini, P. (2017) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2017.1381086 · Cited by 58
Grandi, G., Mueller, M. D., Bersinger, N. A., Papadia, A., Nirgianakis, K., Cagnacci, A., & McKinnon, B. D. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12552 · Cited by 57
Gonadotropin-Releasing Hormone Agonists for Endometriosis
Olive, D. L. (2008) · New England Journal of Medicine · doi:10.1056/nejmct0803719 · Cited by 57
Seracchioli, R., Raimondo, D., Di Donato, N., Leonardi, D., Spagnolo, E., Paradisi, R., Montanari, G., Caprara, G., & Zannoni, L. (2015) · Human Reproduction · doi:10.1093/humrep/deu360 · Cited by 55
Evaluation of the American version of the 30-item Endometriosis Health Profile (EHP-30)
Jenkinson, C., Kennedy, S., & Jones, G. (2008) · Quality of Life Research · doi:10.1007/s11136-008-9403-9 · Cited by 50
Evaluation and treatment of endometriosis.
Schrager, S., Falleroni, J., & Edgoose, J. Y. C. (2013) · PubMed · Cited by 54
Dragoman, M. V., & Gaffield, M. E. (2016) · Contraception · doi:10.1016/j.contraception.2016.02.003 · Cited by 54
Endometriosis: Diagnosis and Management
Leyland, N. A., Casper, R. F., Laberge, P. Y., Singh, S. S., Allen, L. M., Arendas, K., Leyland, N. A., Allaire, C., Awadalla, A., Best, C., et al. (2010) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/228402651000200303 · Cited by 52
Cheewadhanaraks, S., Choksuchat, C., Dhanaworavibul, K., & Liabsuetrakul, T. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000337713 · Cited by 50
Management of Chronic Pelvic Pain
Shin, J. H., & Howard, F. M. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-011-0204-4 · Cited by 50
Guilbert, É., Brown, J. P., Kaunitz, A. M., Wagner, M.-S., Bérubé, J., Charbonneau, L., Francoeur, D., Gilbert, A., Gilbert, F., Roy, G., et al. (2009) · Contraception · doi:10.1016/j.contraception.2008.10.016 · Cited by 50
The place of dydrogesterone in the treatment of endometriosis and adenomyosis
Schweppe, K.-W. (2009) · Maturitas · doi:10.1016/j.maturitas.2009.11.011 · Cited by 48
Sauerbrun‐Cutler, M., & Alvero, R. J. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.09.037 · Cited by 49
Samy, A., Taher, A. M., Sileem, S., Abdelhakim, A. M., Fathi, M. M., Haggag, H. M., Ashour, K., Ahmed, S. A., Shareef, M. A., AlAmodi, A. A., et al. (2020) · Journal of Gynecology Obstetrics and Human Reproduction · doi:10.1016/j.jogoh.2020.101798 · Cited by 44
Prise en charge d'une endométriose douloureuse
Roman, H. (2007) · Journal de gynécologie, obstétrique et biologie de la reproduction. Supplément/Journal de gynécologie obstétrique et biologie de la reproduction · doi:10.1016/j.jgyn.2006.12.008 · Cited by 42
Tolerability considerations for gonadotropin-releasing hormone analogues for endometriosis
Corte, L. D., Barra, F., Mercorio, A., Evangelisti, G., Rapisarda, A. M. C., Ferrero, S., Bifulco, G., & Giampaolino, P. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2020.1789591 · Cited by 44
Jones, G. L., Budds, K., Taylor-Phillips, F., Musson, D., Raymer, J., Churchman, D., Kennedy, S., & Jenkinson, C. (2023) · Human Reproduction Update · doi:10.1093/humupd/dmad029 · Cited by 51
Long-acting contraceptives in adolescents
Tolaymat, L. L., & Kaunitz, A. M. (2007) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3282ef1cd2 · Cited by 40
Novel drug delivery methods for improving efficacy of endometriosis treatments
Garzon, S., Laganà, A. S., Barra, F., Casarin, J., Cromi, A., Raffaelli, R., Uccella, S., Franchi, M. P., Ghezzi, F., & Ferrero, S. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1829589 · Cited by 42
Gonadotropin-releasing hormone analogues for endometriosis
Veth, V. B., van de Kar, M. M., Duffy, J. M., van Wely, M., Mijatovic, V., & Maas, J. W. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd014788.pub2 · Cited by 39
Emerging drugs in endometriosis
Mihalyi, A., Simsa, P., Kyama, C. M., Meuleman, C., Mwenda, J. M., & D’Hooghe, T. (2006) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.11.3.503 · Cited by 38
Taylor, H. S., Dun, E. C., & Chwalisz, K. (2019) · Pain Management · doi:10.2217/pmt-2019-0010 · Cited by 38
Advances in pharmacotherapy for treating endometriosis
Tafi, E., Maggiore, U. L. R., Alessandri, F., Bogliolo, S., Gardella, B., Vellone, V. G., Grillo, F., Mastracci, L., & Ferrero, S. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1085510 · Cited by 38
Management of endometriosis: Toward value-based, cost-effective, affordable care
Vercellini, P., Facchin, F., Buggio, L., Barbara, G., Berlanda, N., Frattaruolo, M. P., & Somigliana, E. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2017.07.011 · Cited by 36
Effects of Dienogest on Surgically Induced Endometriosis in Rats after Repeated Oral Administration
Fischer, O. M., Kaufmann-Reiche, U., Moeller, C., & Fuhrmann, U. (2011) · Gynecologic and Obstetric Investigation · doi:10.1159/000331642 · Cited by 36
The role of progestins in treating the pain of endometriosis
Surrey, E. S. (2006) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2006.06.008 · Cited by 36
Female Sexual Function in Women with Suspected Deep Infiltrating Endometriosis
Lima, R. V., Pereira, A. M. G., Beraldo, F. B., Gazzo, C., Martins, J. A., & Lopes, R. G. C. (2018) · Revista Brasileira Ginecologia e Obstetrícia · doi:10.1055/s-0038-1639593 · Cited by 35
Advances in targeting estrogen synthesis and receptors in patients with endometriosis
Clemenza, S., Vannuccini, S., Ruotolo, A., Capezzuoli, T., & Petraglia, F. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2152325 · Cited by 34
DiVasta, A. D., & Laufer, M. R. (2013) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32836343eb · Cited by 32
Ács, N., O’Brien, C., Jiang, P. X., Burke, J., Jimenez, R., Garner, E. I. O., & Chwalisż, K. (2015) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000211 · Cited by 31
Treatment of endometriosis-related pain options and outcomes
Somigliana, E. (2009) · Frontiers in Bioscience-Elite · doi:10.2741/e41 · Cited by 29
Contraception and endometriosis: challenges, efficacy, and therapeutic importance
Fraser, I. S., & Weisberg, E. (2015) · Open Access Journal of Contraception · doi:10.2147/oajc.s56400 · Cited by 27
Behnamfar, F., Ghahiri, A., & Tavakoli, M. (2014) · Europe PMC (PubMed Central) · Cited by 27
Burke, A. E. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.04.033 · Cited by 26
Effects of hypogonadism on bone metabolism in female adolescents and young adults
Misra, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.238 · Cited by 24
Considerations for the use of progestin‐only contraceptives
Freeman, S. B., & SHULMAN, L. P. (2010) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2009.00473.x · Cited by 24
Moradan, S., Nikkhah, N., & Mirmohammadkhani, M. (2017) · Advances in Therapy · doi:10.1007/s12325-017-0509-8 · Cited by 23
Bourdel, N., Roman, H., Mage, G., & Canis, M. J. (2011) · Gynécologie Obstétrique & Fertilité · doi:10.1016/j.gyobfe.2011.07.051 · Cited by 23
Wang, S.-T., Johnson, S. J., Mitchell, D., Soliman, A. M., Vora, J. B., & Agarwal, S. K. (2019) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2018-0124 · Cited by 22
Postoperative desogestrel for pelvic endometriosis-related pain: a randomized controlled trial
Tanmahasamut, P., Saejong, R., Rattanachaiyanont, M., Angsuwathana, S., Techatraisak, K., & Sa‐nga‐areekul, N. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1296124 · Cited by 22
Templeman, C. E. (2009) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2008.12.005 · Cited by 21
A review of phase II and III drugs for the treatment and management of endometriosis
Perrone, U., Evangelisti, G., Laganà, A. S., Bogliolo, S., Ceccaroni, M., Izzotti, A., Gustavino, C., Ferrero, S., & Barra, F. (2023) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2023.2296080 · Cited by 17
Innovations in conservative endometriosis treatment: an updated review.
Ruhland, B., Agic, A., Krampe, J., Diedrich, K., & Hornung, D. (2011) · PubMed · Cited by 18
Endometriosis: An Update on Management
Bernardi, L. A., & Pavone, M. E. (2013) · Women s Health · doi:10.2217/whe.13.24 · Cited by 16
Effect of neuromuscular electrical stimulation for endometriosis-associated pain
Bi, X.-L., & Xie, C. (2018) · Medicine · doi:10.1097/md.0000000000011266 · Cited by 17
Endometriosis: associations with menopause, hormone replacement therapy and cancer
Palep-Singh, M., & Gupta, S. (2009) · Menopause international · doi:10.1258/mi.2009.009041 · Cited by 16
Update in Female Reproduction: A Life-Cycle Approach
Barbieri, R. L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0752 · Cited by 15
Bulun, S. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-47912-7.00025-1 · Cited by 14
Endométriose et douleurs pelvipérinéales chroniques
Roman, H., Bourdel, N., Rigaud, J., Delavierre, D., Labat, J.-J., & Sibert, L. (2010) · The French Journal of Urology · doi:10.1016/j.purol.2010.08.007 · Cited by 13
Rosenberger, D. C., Mennicken, E., Schmieg, I., Medkour, T., Péchard, M., Sachau, J., Fuchtmann, F., Birch, J. V., Schnabel, K., Vincent, K., et al. (2024) · Pain · doi:10.1097/j.pain.0000000000003290 · Cited by 13
Aromatase inhibitor (anastrozole) affects growth of endometrioma cells in culture
Badawy, S. Z. A., Brown, S. J., Kaufman, L., & Wojtowycz, M. (2015) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2015.01.009 · Cited by 12
National consensus on management patients with endometriosis
Запорожан, В. М., Татарчук, Т. Ф., & Володимирович, К. В. (2015) · Reproductive Endocrinology · doi:10.18370/2309-4117.2015.24.7-12 · Cited by 12
Long-term treatment of endometriosis with dienogest for up to five years
Takagi, H., Sakamoto, J., & Sasagawa, T. (2019) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog4720.2019 · Cited by 12
Injectable contraception: issues and opportunities
Kaunitz, A. M., Peipert, J. F., & Grimes, D. A. (2014) · Contraception · doi:10.1016/j.contraception.2014.03.014 · Cited by 12
Naem, A., Krentel, H., Moawad, G., Naem, J., Venezia, R., Etrusco, A., Terzic, S., & Laganà, A. S. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2024.102500 · Cited by 15
Poulos, C. M., Soliman, A. M., Tekin, S., & Agarwal, S. K. (2020) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1080/14737167.2021.1832468 · Cited by 9
The current place of progestins in the treatment of endometriosis
Schweppe, K.-W. (2012) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.11.71 · Cited by 9
Cheewadhanaraks, S., Peeyananjarassri, K., Choksuchat, C., Dhanaworavibul, K., Choobun, T., & Bunyapipat, S. (2009) · Gynecologic and Obstetric Investigation · doi:10.1159/000226090 · Cited by 9
Taylor, R. N., & Lebovic, D. I. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4907-4.00024-3 · Cited by 8
Safety and efficacy of pharmacotherapies for pelvic inflammatory disease and endometriosis
Ferrero, S., Maggiore, U. L. R., Paudice, M., Vellone, V. G., Perrone, U., & Barra, F. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2446424 · Cited by 8
Progestagens for pain symptoms associated with endometriosis
Chen, I., Kives, S. L., Zakhari, A., Nguyen, D. B., Goldberg, H. R., Choudhry, A. J., Le, A.-L., Kowalczewski, E., & Schroll, J. B. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002122.pub3 · Cited by 7
Metadata
- Authors
- Schlaff, W. D., Carson, S. A., Luciano, A., Ross, D., & Bergqvist, A.
- Affiliations
- University of Colorado Health (US)
- Baylor College of Medicine (US)
- University of Connecticut (US)
- Pfizer (United States) (US)
- Karolinska Institutet (SE)
- Corresponding author
- Schlaff, William D.
- ORCID
- Luciano, Anthony
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 85
- Issue
- 2
- Pages
- 314-325
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2017780870
- Semantic Scholar
- e24478c88204964afa49b33817b516679f38a0a8
- Cited by
- 168
- References
- 28
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 4 · 2015: 14 · 2014: 7 · 2013: 13 · 2012: 11
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- endometriosis, endometriosis-associated pain, depot medroxyprogesterone acetate, leuprolide, GnRH agonist, GnRH antagonist, subcutaneous injection, bone mineral density, dysmenorrhea, dyspareunia, pelvic pain, irregular bleeding, weight change
- MeSH terms
- Adult, Delayed-Action Preparations, Endometriosis, Estrogens, Female, Flushing, Humans, Injections, Subcutaneous, Pain, Palliative Care, Quality of Life, Uterine Hemorrhage, Bone Density, Single-Blind Method, Leuprolide, Treatment Outcome, Medroxyprogesterone Acetate
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