Evaluation of the American version of the 30-item Endometriosis Health Profile (EHP-30)
Abstract
Objectives Health status instruments, which measure the subjective functioning and well-being of respondents, are increasingly being used in international, multi-centre trials of new treatments. If the results of such trials in different countries are to be pooled, it is vitally important for researchers to know how comparable the instruments are across cultures. In this study, we evaluated the response rate, data quality, score reliability and scaling assumptions of the 30-item Endometriosis Health Profile (EHP-30) in the USA.Methods Data were obtained from a multi-centre study which recruited 225 patients from 43 clinic sites in the United States of America. It was a randomised, evaluator-blinded, Phase III study. In the evaluation of the EHP-30 reported here, the two groups (Depot Medroxyprogesterone Acetate [DMPA] and Leuprolide Acetate [LA]) are combined, and analyses are based on the data gained at baseline. Questionnaires were self-completed by patients when they visited the clinics.Results Data completeness was very high, with 97.33% of respondents completing all of the items on the EHP-30. Furthermore, there were no more than a maximum of two missing responses for any given item. No floor and ceiling effects were found for any of the dimensions of the questionnaire. Internal consistency reliability was high for all dimensions (alpha ranged from 0.84 to 0.91). The psychometric properties of the instrument, outlined in the development of the UK version, are supported in the American context.Conclusions The data presented here suggest that the EHP-30 is a valid and reliable measure that can be appropriately and meaningfully used in studies that include respondents from the USA.
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EHP-30 and its abbreviated form EHP-5 are the sole validated instruments specific to endometriosis for measuring HRQoL.
“To date, the only validated endometriosis-specific HRQoL instruments are EHP-30 and its shorter version, EHP-5 (25-29).”
From Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity (2011) · cites this paper as [25]
The EHP-30 and EHP-5 instruments have been translated and validated in multiple populations.
“The endometriosis-specific surveys EHP-30/EHP-5 have been translated and validated in several populations (25, 30, 31, 44); however, these valuable instruments have not been widely used.”
From Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity (2011) · cites this paper as [25]
Items on the EHP-30 do not appear to reflect a single underlying construct, and scores from the questionnaire are best interpreted as subscale scores.
“Consequently, items on the EHP-30 do not appear to reflect a single underlying construct as suggested by Jenkinson et al. (2008), and scores from the questionnaire are best interpreted as subscale scores.”
From Health-related quality of life in women with endometriosis: psychometric validation of the Endometriosis Health Profile 30 questionnaire using confirmatory factor analysis (2022) · cites this paper as Jenkinson et al., 2008
To date, four studies have supported the original five-factor structure of the EHP-30, one study found a four-factor structure, one obtained mixed results and suggested four to five factors, and two recent studies suggested a three-factor structure.
“To date, four studies have supported the original five-factor structure of the EHP-30 (Jenkinson et al., 2008 (American); Jia et al., 2013 (Chinese); Nojomi et al., 2011 (Persian); van de Burgt et al., 2011 (Dutch)), one study found a four-factor structure (Jones et al., 2006 (English)), and one obtained mixed results and suggested four to five factors (Chauvet et al., 2017 (French)). Two recent”
From Health-related quality of life in women with endometriosis: psychometric validation of the Endometriosis Health Profile 30 questionnaire using confirmatory factor analysis (2022) · cites this paper as Jenkinson et al., 2008
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- Authors
- Jenkinson, C., Kennedy, S., & Jones, G.
- Affiliations
- University of Oxford (GB)
- University of Sheffield (GB)
- Corresponding author
- Jenkinson, Crispin
- Venue
- Quality of Life Research
- Published
- 2008-10-10
- Volume
- 17
- Issue
- 9
- Pages
- 1147-1152
- ISSN
- 0962-9343 (ISSN-L)
- 1573-2649
- OpenAlex
- W2045705248
- Cited by
- 50
- References
- 18
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Quality of Life Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Education › Health Education and Validation
- Keywords
- endometriosis, health status questionnaires, psychometric validation, cross-cultural comparability, internal consistency, response rate, data quality, floor and ceiling effects, US patients, quality of life
- MeSH terms
- Adult, Endometriosis, Female, Health Status, Humans, Psychometrics, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, United States, Leuprolide, Medroxyprogesterone Acetate, Antineoplastic Agents, Hormonal
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