Current and emerging treatment options for endometriosis
Abstract
INTRODUCTION: Pharmacotherapy has a pivotal role in the management of endometriosis with long-term treatments balancing clinical efficacy (control of pain symptoms and prevention of recurrence of the disease after surgery) with an acceptable safety profile. Treatment choice is based on several factors including age and patient preference, reproductive plans, intensity of pain, severity of disease and incidence of adverse effects. AREAS COVERED: The aim of this review is to provide the reader with a complete overview of drugs that are currently available or are under investigation for the treatment of endometriosis highlighting on-going clinical trials. EXPERT OPINION: Almost all of the available treatment options for endometriosis suppress ovarian function and are not curative. Combined oral contraceptives and progestins are commonly administered to these patients in order to ameliorate pain symptoms. Gonadotropin-releasing hormone-agonists are prescribed when first-line therapies are ineffective, not tolerated or contraindicated. Aromatase inhibitors should be reserved only for women who are refractory to other treatments. Amongst the drugs under development, gonadotropin-releasing hormone antagonists have shown the most promising results. Presently, are a number of potential therapies currently in pre-clinical or early clinical studies which may alter treatment strategies in the future although further studies are necessary.
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Hormonal treatment impedes conception, excluding this approach in women wishing to conceive.
“However, hormonal treatment also impedes conception, excluding this approach in women wishing to conceive [1,4].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [4]
Cites
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
Bresalier, R. S., Sandler, R. S., Quan, H., Bolognese, J. A., Oxenius, B., Horgan, K., Lines, C., Riddell, R., Morton, D., Lanas, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050493 · Cited by 2,519 · see citing works
ESHRE guideline: management of women with endometriosis
Dunselman, G. A. J., Vermeulen, N., Becker, C., Calhaz-Jorge, C., D'Hooghe, T., De Bie, B., Heikinheimo, O., Horne, A. W., Kiesel, L., Nap, A., et al. (2014) · Human Reproduction · doi:10.1093/humrep/det457 · Cited by 2,211 · see citing works
Erasers of Histone Acetylation: The Histone Deacetylase EnzymesPreprint
Seto, E., & Yoshida, M. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018713 · Cited by 2,019 · see citing works
Endometriosis: pathogenesis and treatment
Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.255 · Cited by 1,940 · see citing works
Pathogenesis and pathophysiology of endometriosis
Burney, R. O., & Giudice, L. C. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.06.029 · Cited by 1,590 · see citing works
(1927) · PubMed Central · Cited by 1,008 · see citing works
Clinical Management of Endometriosis
Falcone, T., & Flyckt, R. L. (2018) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002469 · Cited by 582 · see citing works
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist
Taylor, H. S., Giudice, L. C., Lessey, B. A., Abrao, M. S., Kotarski, J., Archer, D. F., Diamond, M. P., Surrey, E., Johnson, N. P., Watts, N. B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1700089 · Cited by 511 · see citing works
Strowitzki, T., Marr, J., Gerlinger, C., Faustmann, T., & Seitz, C. (2010) · Human Reproduction · doi:10.1093/humrep/dep469 · Cited by 381 · cited 1× · see citing works
“In these studies, the severity of women’s pain symptoms decreased significantly without inter-group differences [39,40].”
BackgroundPetta, C. A., Ferriani, R. A., Abrao, M. S., Hassan, D., Rosa e Silva, J. C., Podgaec, S., & Bahamondes, L. (2005) · Human Reproduction · doi:10.1093/humrep/deh869 · Cited by 363 · see citing works
Laparoscopic surgery for endometriosis
Duffy, J. M., Arambage, K., Correa, F. J., Olive, D. L., Farquhar, C. M., Garry, R., Barlow, D. H., & Jacobson, T. Z. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011031.pub2 · Cited by 352 · see citing works
Surgical Treatment of Endometriosis: A 7-Year Follow-up on the Requirement for Further Surgery
Shakiba, K., Bena, J. F., McGill, K. M., Minger, J., & Falcone, T. (2008) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e3181758ec6 · Cited by 339 · see citing works
Progesterone resistance in endometriosis: origins, consequences and interventions
Patel, B. G., Rudnicki, M., Yu, J., Shu, Y., & Taylor, R. N. (2017) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13156 · Cited by 336 · see citing works
Phase II Study of Everolimus and Letrozole in Patients With Recurrent Endometrial Carcinoma
Slomovitz, B. M., Jiang, Y., Yates, M. S., Soliman, P. T., Johnston, T., Nowakowski, M., Levenback, C., Zhang, Q., Ring, K. L., Munsell, M. F., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.3401 · Cited by 324 · see citing works
Vercellini, P., Trespidi, L., Colombo, A., Vendola, N., Marchini, M., & Crosignani, P. G. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56039-7 · Cited by 311 · see citing works
Chwalisz, K., Perez, M. C., DeManno, D., Winkel, C., Schubert, G., & Elger, W. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0001 · Cited by 310 · see citing works
Harada, T., Momoeda, M., Taketani, Y., Hoshiai, H., & Terakawa, N. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.051 · Cited by 289 · see citing works
Dlugi, A. M., Miller, J. D., & Knittle, J. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53755-8 · Cited by 279 · see citing works
Harada, T., Momoeda, M., Taketani, Y., Asô, T., Fukunaga, M., Hagino, H., & Terakawa, N. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.080 · Cited by 277 · see citing works
Clinical Management of Endometriosis
Falcone, T., & Lebovic, D. I. (2011) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e31822adfd1 · Cited by 263 · see citing works
Laparoscopic surgery for endometriosis
Bafort, C., Beebeejaun, Y., Tomassetti, C., Bosteels, J., & Duffy, J. M. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011031.pub3 · Cited by 261 · cited 1× · see citing works
“Surgical excision of endometriosis significantly ameliorates pain symptoms [2]; however, it may be associated”
BackgroundArimidex�: A potent and selective fourth-generation aromatase inhibitor
Plourde, P. V., Dyroff, M. C., & Dukes, M. (1994) · Breast Cancer Research and Treatment · doi:10.1007/bf00682745 · Cited by 258 · see citing works
Progestagens and anti-progestagens for pain associated with endometriosis
Brown, J., Kives, S., & Akhtar, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002122.pub2 · Cited by 250 · see citing works
Estrogen-progestins and progestins for the management of endometriosis
Vercellini, P., Buggio, L., Berlanda, N., Barbara, G., Somigliana, E., & Bosari, S. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.10.022 · Cited by 243 · see citing works
Anti-Angiogenic and Anti-Inflammatory Effects of Statins: Relevance to Anti-Cancer Therapy
Dulak, J., & Józkowicz, A. (2005) · Current Cancer Drug Targets · doi:10.2174/156800905774932824 · Cited by 235 · see citing works
Ailawadi, R., Jobanputra, S., Kataria, M., Gürateş, B., & Bulun, S. E. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.09.029 · Cited by 233 · see citing works
Strowitzki, T., Faustmann, T., Gerlinger, C., & Seitz, C. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.04.002 · Cited by 227 · see citing works
Soysal, S. (2004) · Human Reproduction · doi:10.1093/humrep/deh035 · Cited by 227 · see citing works
Anastrazole and oral contraceptives: a novel treatment for endometriosis
Amsterdam, L. L., Gentry, W. L., Jobanputra, S., Wolf, M., Rubin, S. D., & Bulun, S. E. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.02.018 · Cited by 217 · see citing works
Casper, R. F. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.003 · Cited by 205 · see citing works
Vercellini, P., Pietropaolo, G., De Giorgi, O., Pasin, R., Chiodini, A., & Crosignani, P. G. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.03.083 · Cited by 197 · see citing works
Gonadotrophin-releasing hormone analogues for pain associated with endometriosis
Veth, V. B., van de Kar, M. M., McDonnell, R., Julania, S., & Hart, R. J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008475.pub2 · Cited by 182 · see citing works
Vercellini, P., De Giorgi, O., Mosconi, P., Stellato, G., Vicentini, S., & Crosignani, P. G. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02951-x · Cited by 180 · see citing works
Crosignani, P. G., Luciano, A., Ray, A., & Bergqvist, A. (2006) · Human Reproduction · doi:10.1093/humrep/dei290 · Cited by 179 · see citing works
Schlaff, W. D., Carson, S. A., Luciano, A., Ross, D., & Bergqvist, A. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.07.1315 · Cited by 168 · see citing works
Dienogest in the treatment of endometriosis: systematic review
Andres, M. P., Lopes, L. A., Baracat, E. C., & Podgaec, S. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3681-6 · Cited by 166 · see citing works
Diet and endometriosis risk: A literature review
Parazzini, F., Viganò, P., Candiani, M., & Fedele, L. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.12.011 · Cited by 165 · see citing works
Anti-TNF- treatment for deep endometriosis-associated pain: a randomized placebo-controlled trial
Koninckx, P. R., Craessaerts, M., Timmerman, D., Cornillie, F., & Kennedy, S. (2008) · Human Reproduction · doi:10.1093/humrep/den177 · Cited by 165 · see citing works
Vercellini, P., De Giorgi, O., Oldani, S., Cortesi, I., Panazza, S., & Crosignani, P. G. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70152-7 · Cited by 161 · see citing works
Cosson, M., Querleu, D., Donnez, J., Madelenat, P., Konincks, P., Audebert, A., & Manhes, H. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03270-8 · Cited by 153 · see citing works
Anti-angiogenic treatment strategies for the therapy of endometriosis
Laschke, M. W., & Menger, M. D. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms026 · Cited by 151 · see citing works
Cobellis, L., Razzi, S., Simone, S. D., Sartini, A., Fava, A., Danero, S., Gioffrè, W. R., Mazzini, M., & Petraglia, F. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.02.007 · Cited by 140 · see citing works
Stratton, P., Sinaii, N., Segars, J., Koziol, D., Wesley, R., Zimmer, C., Winkel, C., & Nieman, L. K. (2008) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000297307.35024.b5 · Cited by 140 · see citing works
Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress
Augoulea, A., Alexandrou, A. P., Creatsa, M. G., Vrachnis, N., & Lambrinoudaki, I. V. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2357-8 · Cited by 140 · see citing works
Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model.
Xu, H., Lui, W. T., Chu, C., Ng, P., Wang, C.-C., & Rogers, M. S. (2008) · Human Reproduction · doi:10.1093/humrep/den417 · Cited by 134 · see citing works
Bayoglu Tekin, Y., Dilbaz, B., Altinbas, S. K., & Dilbaz, S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.08.042 · Cited by 133 · see citing works
D’Hooghe, T. M., Nugent, N. P., Cuneo, S., Chai, D. C., Deer, F., Debrock, S., Kyama, C. M., Mihalyi, A., & Mwenda, J. M. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.043349 · Cited by 132 · see citing works
Use of GnRH antagonists in the treatment of endometriosis
Küpker, W., Felberbaum, R. E., Krapp, M., Schill, T., Malik, E., & Diedrich, K. (2002) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61590-8 · Cited by 130 · see citing works
Therapeutic Effect of Angiostatin Gene Transfer in a Murine Model of Endometriosis
Dabrosin, C., Gyorffy, S., Margetts, P. J., Ross, C. A., & Gauldie, J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64251-4 · Cited by 128 · see citing works
Walch, K., Unfried, G., Huber, J., Kurz, C., van Trotsenburg, M., Pernicka, E., & Wenzl, R. (2009) · Contraception · doi:10.1016/j.contraception.2008.07.017 · Cited by 128 · see citing works
Novella-Maestre, E., Cardá, C., Noguera, I., Ruiz‐Saurí, A., García-Velasco, J. A., Simón, C., & Pellicer, A. (2009) · Human Reproduction · doi:10.1093/humrep/den499 · Cited by 128 · see citing works
Basic mechanisms of vascularization in endometriosis and their clinical implications
Laschke, M. W., & Menger, M. D. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy001 · Cited by 128 · see citing works
Lebovic, D. I., Kir, M., & Casey, C. L. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.148 · Cited by 127 · see citing works
Hornstein, M. D., Yuzpe, A. A., Burry, K. A., Heinrichs, L. R., Buttram, V. C., & ORWOLL, E. S. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57530-x · Cited by 125 · see citing works
Treatment of pain associated with deep endometriosis: alternatives and evidence
Ferrero, S., Alessandri, F., Racca, A., & Maggiore, U. L. R. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.031 · Cited by 124 · see citing works
Self-citationZhang, R., Wild, R. A., & Ojago, J. M. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55976-7 · Cited by 124 · see citing works
Basu, S., Sarkar, C., Chakroborty, D., Nagy, J. A., Mitra, R. B., Dasgupta, P., & Mukhopadhyay, D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1600 · Cited by 123 · see citing works
Ovulation suppression for endometriosis for women with subfertility
Hughes, E., Brown, J., Collins, J. J., Farquhar, C., Fedorkow, D. M., & Vanderkerchove, P. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000155.pub2 · Cited by 121 · see citing works
Diamond, M. P., Carr, B. R., Dmowski, W. P., Koltun, W. D., O'Brien, C. F., Jiang, P. X., Burke, J., Jimenez, R., Garner, E. I. O., & Chwalisż, K. (2013) · Reproductive Sciences · doi:10.1177/1933719113497292 · Cited by 121 · see citing works
Strowitzki, T., Faustmann, T., Gerlinger, C., Schumacher, U., Ahlers, C., & Seitz, C. (2015) · International Journal of Women's Health · doi:10.2147/ijwh.s77202 · Cited by 120 · see citing works
Guzick, D. S., Huang, L., Broadman, B. A., Nealon, M., & Hornstein, M. D. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.027 · Cited by 120 · see citing works
Mariani, M., Viganò, P., Gentilini, D., Camisa, B., Caporizzo, E., Lucia, P. D., Monno, A., Candiani, M., Somigliana, E., & Panina‐Bordignon, P. (2012) · Human Reproduction · doi:10.1093/humrep/des150 · Cited by 116 · see citing works
The mTOR/AKT Inhibitor Temsirolimus Prevents Deep Infiltrating Endometriosis in Mice
Leconte, M., Nicco, C., Ngô, C., Chéreau, C., Chouzenoux, S., Marut, W., Guibourdenche, J., Arkwright, S., Weill, B. J., Chapron, C., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.04.020 · Cited by 115 · see citing works
Carr, B., Dmowski, W. P., O’Brien, C., Jiang, P., Burke, J., Jimenez, R., Garner, E., & Chwalisz, K. (2014) · Reproductive Sciences · doi:10.1177/1933719114549848 · Cited by 114 · see citing works
Molecular biology of endometriosis: from aromatase to genomic abnormalities
Monsivais, D., Kakinuma, T., Furukawa, Y., Bernardi, L., Pavone, M., Dyson, M., & Bulun, S. (2015) · Seminars in Reproductive Medicine · doi:10.1055/s-0035-1554053 · Cited by 112 · see citing works
Comparison of contraceptive ring and patch for the treatment of symptomatic endometriosis
Vercellini, P., Barbàra, G., Somigliana, E., Bianchi, S., Abbiati, A., & Fedele, L. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.071 · Cited by 112 · see citing works
Kulak, J., Fischer, C., Komm, B., & Taylor, H. S. (2011) · Endocrinology · doi:10.1210/en.2010-1010 · Cited by 112 · see citing works
Lu, Y., Nie, J., Liu, X., Zheng, Y., & Guo, S. (2010) · Human Reproduction · doi:10.1093/humrep/dep472 · Cited by 111 · see citing works
Falconer, H., Mwenda, J. M., Chai, D. C., Wagner, C. L., Song, X.-Y. R., Mihalyi, A., Simsa, P., Kyama, C. M., Cornillie, F. J., Bergqvist, A., et al. (2006) · Human Reproduction · doi:10.1093/humrep/del044 · Cited by 108 · see citing works
Norethisterone acetate in the treatment of colorectal endometriosis: a pilot study
Ferrero, S., Camerini, G., Ragni, N., Venturini, P. L., Biscaldi, E., & Remorgida, V. (2010) · Human Reproduction · doi:10.1093/humrep/dep361 · Cited by 107 · see citing works
Self-citationBraun, D. P., Ding, J., & Dmowski, W. P. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03318-6 · Cited by 105 · see citing works
Ricci, A. G., Olivares, C. N., Bilotas, M. A., Meresman, G. F., & Barañao, R. I. (2011) · Reproductive Sciences · doi:10.1177/1933719110395406 · Cited by 104 · see citing works
Endostatin inhibits the growth of endometriotic lesions but does not affect fertility
Becker, C. M., Sampson, D. A., Rupnick, M. A., Rohan, R. M., Efstathiou, J. A., Short, S. M., Taylor, G. A., Folkman, J., & D’Amato, R. J. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.040 · Cited by 102 · see citing works
Barra, F., Scala, C., & Ferrero, S. (2018) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1461840 · Cited by 100 · see citing works
Self-citationEffects of Triptorelin Versus Placebo on the Symptoms of Endometriosis
Bergqvist, A., Bergh, T., Hogström, L., Mattsson, S., Nordenskjöld, F., & Rasmussen, C. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00019-3 · Cited by 99 · see citing works
Laschke, M. W., Schwender, C., Scheuer, C., Vollmar, B., & Menger, M. D. (2008) · Human Reproduction · doi:10.1093/humrep/den245 · Cited by 98 · see citing works
Sesti, F., Pietropolli, A., Capozzolo, T., Broccoli, P., Pierangeli, S., Bollea, M. R., & Piccione, E. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.053 · Cited by 97 · see citing works
Hormonal therapy for endometriosis: from molecular research to bedside
Tosti, C., Biscione, A., Morgante, G., Bifulco, G., Luisi, S., & Petraglia, F. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.05.032 · Cited by 96 · see citing works
Kettel, L. M., Murphy, A. A., Morales, A. J., & Yen, S. S. C. (1994) · Human Reproduction · doi:10.1093/humrep/9.suppl_1.116 · Cited by 95 · see citing works
Antifibrotic properties of epigallocatechin-3-gallate in endometriosis
Matsuzaki, S., & Darcha, C. (2014) · Human Reproduction · doi:10.1093/humrep/deu123 · Cited by 95 · see citing works
Hefler, L., Grimm, C., van Trotsenburg, M., & Nagele, F. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.059 · Cited by 93 · see citing works
Dienogest: A New Therapeutic Agent for the Treatment of Endometriosis
Harada, T., & Taniguchi, F. (2010) · Women s Health · doi:10.2217/whe.09.72 · Cited by 92 · see citing works
Sakr, S., Naqvi, H., Komm, B., & Taylor, H. S. (2014) · Endocrinology · doi:10.1210/en.2013-1977 · Cited by 91 · see citing works
Maia, H., Haddad, Pinheiro, & Casoy, J. (2012) · International Journal of Women s Health · doi:10.2147/ijwh.s36825 · Cited by 87 · see citing works
Simvastatin Protects against the Development of Endometriosis in a Nude Mouse Model
Bruner‐Tran, K. L., Osteen, K. G., & Dulęba, A. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2802 · Cited by 87 · see citing works
Aromatase and endometriosis: estrogens play a role
Ferrero, S., Remorgida, V., Maganza, C., Venturini, P. L., Salvatore, S., Papaleo, E., Candiani, M., & Maggiore, U. L. R. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12411 · Cited by 84 · see citing works
Self-citationA pilot study on the off-label use of valproic acid to treat adenomyosis
Liu, X., & Guo, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.009 · Cited by 84 · see citing works
Letrozole and desogestrel‐only contraceptive pill for the treatment of stage IV endometriosis
REMORGIDA, V., ABBAMONTE, L. H., RAGNI, N., FULCHERI, E., & FERRERO, S. (2007) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2007.00722.x · Cited by 83 · see citing works
Self-citationMoggio, A., Pittatore, G., Cassoni, P., Marchino, G. L., Revelli, A., & Bussolati, B. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.003 · Cited by 82 · see citing works
Gómez, R., Abad, A., Delgado, F., Tamarit, S., Simón, C., & Pellicer, A. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.10.024 · Cited by 81 · see citing works
da Silva, D. M., Gross, L. A., Neto, E. D. P. G., Lessey, B. A., & Savaris, R. F. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00053 · Cited by 81 · see citing works
Letrozole and norethisterone acetate in colorectal endometriosis
Ferrero, S., Camerini, G., Ragni, N., Venturini, P. L., Biscaldi, E., Seracchioli, R., & Remorgida, V. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.02.023 · Cited by 80 · see citing works
Self-citationLeone Roberti Maggiore, U., Remorgida, V., Scala, C., Tafi, E., Venturini, P. L., & Ferrero, S. (2014) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.12326 · Cited by 80 · see citing works
Self-citationPorpora, M. G., Brunelli, R., Costa, G., Imperiale, L., Krasnowska, E. K., Lundeberg, T., Nofroni, I., Piccioni, M. G., Pittaluga, E., Ticino, A., et al. (2013) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2013/240702 · Cited by 80 · see citing works
Lebovic, D. I., Mwenda, J. M., Chai, D. C., Mueller, M. D., Santi, A., Fisseha, S., & D’Hooghe, T. M. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.072 · Cited by 79 · see citing works
Delgado-Rosas, F., Gómez, R., Ferrero, H., Gaytán, F., García-Velasco, J. A., Simón, C., & Pellicer, A. (2011) · Reproduction · doi:10.1530/rep-11-0223 · Cited by 79 · see citing works
Epigenetic regulation of the pathological process in endometriosis
Hsiao, K., Wu, M., & Tsai, S. (2017) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12047 · Cited by 79 · see citing works
Safety of medical treatments for endometriosis
Berlanda, N., Somigliana, E., Viganò, P., & Vercellini, P. (2016) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2016.1121991 · Cited by 78 · see citing works
Naproxen sodium in dysmenorrhea secondary to endometriosis.
Kauppila, A., & Rönnberg, L. (1985) · PubMed · Cited by 77 · see citing works
Ferrero, S., Venturini, P. L., Gillott, D. J., & Remorgida, V. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-88 · Cited by 77 · see citing works
Self-citationMachado, D. E., Berardo, P. T., Landgraf, R. G., Fernandes, P. D., Palmero, C. Y., Miranda‐Alves, L., Abrão, M. S., & Nasciutti, L. E. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.11.037 · Cited by 76 · see citing works
The Efficacy of Bevacizumab, Sorafenib, and Retinoic Acid on Rat Endometriosis Model
Özer, H., Boztosun, A., Açmaz, G., Atılgan, R., Akkar, Ö. B., & Koşar, M. İ. (2012) · Reproductive Sciences · doi:10.1177/1933719112452941 · Cited by 75 · see citing works
Wu, Y., & Guo, S. (2007) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2007.02.014 · Cited by 74 · see citing works
Fedele, L., Bianchi, S., Bocciolone, L., Di Nola, G., & Franchi, D. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55792-6 · Cited by 74 · see citing works
Morotti, M., Remorgida, V., Venturini, P. L., & Ferrero, S. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.05.016 · Cited by 72 · see citing works
Self-citationLetrozole and norethisterone acetate in rectovaginal endometriosis
Remorgida, V., Abbamonte, L. H., Ragni, N., Fulcheri, E., & Ferrero, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.027 · Cited by 72 · see citing works
Self-citationLaschke, M. W., Elitzsch, A., Scheuer, C., Holstein, J. H., Vollmar, B., & Menger, M. D. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706857 · Cited by 70 · see citing works
Dmowski, W. P., Radwańska, E., Binor, Z., Tummon, I. S., & Pepping, P. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60543-5 · Cited by 70 · see citing works
Prostaglandin biosynthesis inhibitors and endometriosis
Kauppila, A., Puolakka, J. O., & Ylikorkala, O. (1979) · Prostaglandins · doi:10.1016/0090-6980(79)90033-9 · Cited by 68 · see citing works
Cetel, N. S., Rivier, J., Vale, W., & Yen, S. S. C. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-57-1-62 · Cited by 68 · see citing works
Resveratrol and endometriosis: In vitro and animal studies and underlying mechanisms (Review)
Kolahdouz‐Mohammadi, R., & Arablou, T. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.078 · Cited by 68 · see citing works
The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis
Olivares, C., Ricci, A., Bilotas, M., Barañao, R. I., & Meresman, G. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.063 · Cited by 65 · see citing works
Ferrero, S., Remorgida, V., Venturini, P. L., & Maggiore, U. L. R. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.11.030 · Cited by 65 · see citing works
Self-citationPharmacological Treatment of Endometriosis
Ferrero, S., Venturini, P. L., Ragni, N., Camerini, G. B., & Remorgida, V. (2009) · Drugs · doi:10.2165/00003495-200969080-00001 · Cited by 64 · see citing works
Self-citationBiomarkers of progestin therapy resistance and endometrial hyperplasia progression
Upson, K., Allison, K. H., Reed, S. D., Jordan, C. D., Newton, K. M., Swisher, E. M., Doherty, J. A., & Garcia, R. L. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.05.012 · Cited by 64 · see citing works
Valproic Acid as a Therapy for Adenomyosis: A Comparative Case Series
Liu, X., Yuan, L., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110373807 · Cited by 64 · see citing works
Dienogest in the treatment of endometriosis
Bizzarri, N., Remorgida, V., Leone Roberti Maggiore, U., Scala, C., Tafi, E., Ghirardi, V., Salvatore, S., Candiani, M., Venturini, P. L., & Ferrero, S. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.943734 · Cited by 63 · see citing works
Self-citationYılmaz, B., Sucak, A., Kılıç, S., Aksakal, O., Aksoy, Y., Ünlü, N. L., Süt, N., & Gungor, T. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.10.873 · Cited by 63 · see citing works
Miller, J. D. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.106846 · Cited by 61 · see citing works
Zhang, J.-J., Xu, Z., Zhang, C.-M., et al. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq090 · Cited by 61 · see citing works
Xanthohumol inhibits growth and vascularization of developing endometriotic lesions
Rudzitis‐Auth, J., Körbel, C., Scheuer, C., Menger, M. D., & Laschke, M. W. (2012) · Human Reproduction · doi:10.1093/humrep/des095 · Cited by 61 · see citing works
Yagyu, T., Kobayashi, H., Matsuzaki, H., Wakahara, K., Kondo, T., Kurita, N., Sekino, H., Inagaki, K., Suzuki, M., Kanayama, N., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1946 · Cited by 61 · see citing works
Yao, Z., Shen, X., Capodanno, I., Donnelly, M., Fenyk-Melody, J., Hausamann, J., Nunes, C., Strauss, J., & Vakerich, K. (2005) · Journal of Investigative Surgery · doi:10.1080/08941930591004412 · Cited by 60 · see citing works
New trends for the medical treatment of endometriosis
Rocha, A. L. L., Reis, F. M., & Petraglia, F. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.683783 · Cited by 60 · see citing works
Efficacies of vitamin D and omega-3 polyunsaturated fatty acids on experimental endometriosis
Akyol, A., Şimşek, M., İlhan, R., et al. (2016) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2015.06.018 · Cited by 60 · see citing works
Delvoux, B., D'Hooghe, T., Kyama, C., Koskimies, P., Hermans, R. J. J., Dunselman, G. A., & Romano, A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2851 · Cited by 59 · see citing works
Current pharmacotherapy for endometriosis
Ferrero, S., Remorgida, V., & Venturini, P. L. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656561003685880 · Cited by 59 · see citing works
Self-citationTreatment of endometrioma for improving fertility
Maggiore, U. L. R., Gupta, J. K., & Ferrero, S. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.02.035 · Cited by 59 · see citing works
Self-citationComparison of the effects of raloxifene and anastrozole on experimental endometriosis
Altintas, D., Kokcu, A., Kandemir, B., Tosun, M., & Cetinkaya, M. B. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.02.004 · Cited by 57 · see citing works
Ferrero, S., Leone Roberti Maggiore, U., Scala, C., Di Luca, M., Venturini, P. L., & Remorgida, V. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2581-2 · Cited by 57 · see citing works
Self-citationParazzini, F., Cintio, E. D., Chatenoud, L., Moroni, S., Ardovino, I., Struzziero, E., Falsetti, L., Bianchi, A., Bracco, G., Pellegrini, A., et al. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(99)00131-1 · Cited by 57 · see citing works
Investigational drugs for the treatment of endometriosis, an update on recent developments
Barra, F., Scala, C., Mais, V., Guerriero, S., & Ferrero, S. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1471135 · Cited by 57 · see citing works
Self-citationWieser, F., Wu, J., Shen, Z., Taylor, R. N., & Sidell, N. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.03.004 · Cited by 56 · see citing works
Wu, Y., & Guo, S. (2007) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2006.07.034 · Cited by 55 · see citing works
Tomio, K., Kawana, K., Taguchi, A., Isobe, Y., Iwamoto, R., Yamashita, A., Kojima, S., Mori, M., Nagamatsu, T., Arimoto, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073085 · Cited by 55 · see citing works
Ferreira, R. A., Vieira, C. S., Silva, J. C. R. E., Rosa-e-Silva, A. C. J. S., Nogueira, A. A., & Ferriani, R. A. (2009) · Contraception · doi:10.1016/j.contraception.2009.08.003 · Cited by 55 · see citing works
Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models
Palmer, S. S., Altan, M., Denis, D., Tos, E. G., Gotteland, J., Osteen, K. G., Bruner‐Tran, K. L., & Nataraja, S. G. (2015) · Reproductive Sciences · doi:10.1177/1933719115600553 · Cited by 54 · see citing works
Naqvi, H., Sakr, S., Presti, T., Krikun, G., Komm, B., & Taylor, H. S. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.114165 · Cited by 54 · see citing works
Nasu, K., Nishida, M., Ueda, T., Yuge, A., Takai, N., & Narahara, H. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00135.2006 · Cited by 53 · see citing works
Cheewadhanaraks, S., Choksuchat, C., Dhanaworavibul, K., & Liabsuetrakul, T. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000337713 · Cited by 50 · see citing works
Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis
Netsu, S., Konno, R., Odagiri, K., Soma, M., Fujiwara, H., & Suzuki, M. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.08.014 · Cited by 49 · see citing works
Nenicu, A., Körbel, C., Gu, Y. J., Menger, M. D., & Laschke, M. W. (2014) · Human Reproduction · doi:10.1093/humrep/deu035 · Cited by 49 · see citing works
Lebovic, D. I., Mwenda, J. M., Chai, D. C., Santi, A., Xu, X., & D’Hooghe, T. M. (2010) · Endocrinology · doi:10.1210/en.2009-1076 · Cited by 48 · see citing works
Lemay, A., Maheux, R., Huot, C., Blanchet, J., & Faure, N. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90128-7 · Cited by 48 · see citing works
Yıldız, Ç., Kaçan, T., Akkar, Ö. B., Karakuş, S., Kaçan, S. B., Özer, H., & Çetin, A. (2015) · Reproductive Sciences · doi:10.1177/1933719115584448 · Cited by 47 · see citing works
Nasu, K., Yuge, A., Tsuno, A., & Narahara, H. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.06.055 · Cited by 46 · see citing works
Dienogest. A possible conservative approach in bladder endometriosis. Results of a pilot study
Angioni, S., Nappi, L., Pontis, A., Sedda, F., Luisi, S., Mais, V., & Melis, G. B. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1006617 · Cited by 45 · see citing works
Atorvastatin causes regression of endometriotic implants in a rat model
Yılmaz, B., Özat, M., Kılıç, S., Gungor, T., Aksoy, Y., Lordlar, N., Süt, N., & Aksakal, O. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.11.004 · Cited by 45 · see citing works
Inhibition of steroid sulfatase decreases endometriosis in an in vivo murine model
Colette, S., Defrere, S., Lousse, J. C., Van Langendonckt, A., Gotteland, J. P., Loumaye, E., & Donnez, J. (2011) · Human Reproduction · doi:10.1093/humrep/der079 · Cited by 45 · see citing works
Endometriosis developing during tamoxifen therapy
Ford, M. R. W., Turner, M. J., Wood, C., & Soutter, W. P. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90233-5 · Cited by 44 · see citing works
Morotti, M., Venturini, P. L., Biscaldi, E., Racca, A., Calanni, L., Vellone, V. G., Stabilini, C., & Ferrero, S. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2017.03.033 · Cited by 43 · see citing works
Self-citationKim, J., Yang, Y., Lee, K., Park, H.-J., & Choi, J. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.580 · Cited by 41 · see citing works
A Novel Angiogenesis Inhibitor Bevacizumab Induces Apoptosis in the Rat Endometriosis Model
Soysal, D., Kızıldağ, S., Saatli, B., Posacı, C., Soysal, S., Koyuncuoğlu, M., & Doğan, E. (2014) · Balkan Journal of Medical Genetics · doi:10.2478/bjmg-2014-0077 · Cited by 39 · see citing works
Susanto, L. W., Nofiarny, Susanto, L. W., et al. (2011) · International Journal of General Medicine · doi:10.2147/ijgm.s21053 · Cited by 38 · see citing works
Advances in pharmacotherapy for treating endometriosis
Tafi, E., Maggiore, U. L. R., Alessandri, F., Bogliolo, S., Gardella, B., Vellone, V. G., Grillo, F., Mastracci, L., & Ferrero, S. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1085510 · Cited by 38 · see citing works
Self-citationAgarwal, S. K., Hamrang, C., Henzl, M. R., & Judd, H. L. (1997) · PubMed · Cited by 38 · see citing works
Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain
Álvarez, P., Bogen, O., & Levine, J. D. (2014) · Pain · doi:10.1016/j.pain.2014.09.035 · Cited by 37 · see citing works
Regression of endometrial autografts in a rat model of endometriosis treated with etanercept
İslimye, M., Kılıç, S., Zülfikaroğlu, E., Topcu, O., Zergeroğlu, S., & Batıoğlu, S. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.06.029 · Cited by 35 · see citing works
Struthers, R. S., Chen, T., Campbell, B., Jimenez, R., Pan, H., Yen, S. S. C., & Bozigian, H. P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1110 · Cited by 34 · see citing works
Yamamoto, Y., Shibata, J., Yonekura, K., Sato, K., Hashimoto, A., Aoyagi, Y., Wierzba, K., Yano, S., Asao, T., Buzdar, A. U., et al. (2005) · PubMed · Cited by 34 · see citing works
Efficacy of anti-tumor necrosis factor therapy on endometriosis in an experimental rat model
Zülfikaroğlu, E., Kılıç, S., İslimye, M., Aydın, M., Zergeroğlu, S., & Batıoğlu, S. (2010) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1434-0 · Cited by 33 · see citing works
DiVasta, A. D., & Laufer, M. R. (2013) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32836343eb · Cited by 32 · see citing works
Yamamoto, Y., Shibata, J., Yonekura, K., Sato, K., Hashimoto, A., Aoyagi, Y., Wierzba, K., Yano, S., Asao, T., Buzdar, A. U., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.315.11.1 · Cited by 32 · see citing works
Etanercept causes regression of endometriotic implants in a rat model
Yıldırım, G., Attar, R., Fıçıcıoğlu, C., Karateke, A., Özkan, F., & Yeşildağlar, N. (2010) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1543-9 · Cited by 31 · see citing works
Schultze‐Mosgau, M., Waellnitz, K., Nave, R., Klein, S., Kraetzschmar, J., Rautenberg, T., Schmitz, H., & Rohde, B. (2016) · Human Reproduction · doi:10.1093/humrep/dew145 · Cited by 31 · see citing works
Grandi, G., Mueller, M. D., Bersinger, N. A., Facchinetti, F., & McKinnon, B. D. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1314458 · Cited by 31 · see citing works
Cetrorelix in the treatment of female infertility and endometriosis
Finas, D., Hornung, D., Diedrich, K., & Schultze-Mosgau, A. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.15.2155 · Cited by 30 · see citing works
The effects of sunitinib on endometriosis
Pala, H. G., Erbaş, O., Pala, E. E., Ülkümen, B., Akman, L., Akman, T., Oltulu, F., & Yavaşoğlu, A. (2014) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2014.941345 · Cited by 30 · see citing works
Yamamoto, Y., Wada, O., Takada, I., Yogiashi, Y., Shibata, J., Yanagisawa, J., Kitazato, K., & Kato, S. (2003) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2003.10.178 · Cited by 30 · see citing works
Alteration of Dopamine D2 Receptors in Human Malignant Stomach Tissue
Basu, S., & Dasgupta, P. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018862309440 · Cited by 29 · see citing works
Gonadotrophin-releasing hormone analogues and endometriosis: current strategies and new insights
Hashim, H. A. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.650751 · Cited by 29 · see citing works
Huber, A. V., Saleh, L., Prast, J., Haslinger, P., & Knöfler, M. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam032 · Cited by 29 · see citing works
Pharmacokinetic drug evaluation of ulipristal acetate for the treatment of uterine fibroids
Ferrero, S., Vellone, V. G., & Barra, F. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2018.1417389 · Cited by 29 · see citing works
Self-citationAromatase inhibitors in the treatment of bladder endometriosis
Ferrero, S., Biscaldi, E., Venturini, P. L., & Remorgida, V. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.500425 · Cited by 28 · see citing works
Self-citationSalah, M., Abdelsamie, A. S., & Frotscher, M. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00062 · Cited by 28 · see citing works
Eljarmak, D., Lis, M., Cantin, M., et al. (2008) · Hormone Research · doi:10.1159/000180041 · Cited by 27 · see citing works
Reinecke, I., Schultze‐Mosgau, M., Nave, R., Schmitz, H., & Ploeger, B. A. (2016) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.846 · Cited by 26 · see citing works
Harada, T., Ohta, I., Endo, Y., Sunada, H., Noma, H., & Taniguchi, F. (2017) · Yonago acta medica · doi:10.33160/yam.2017.12.003 · Cited by 26 · see citing works
Mifepristone 2.5, 5, 10mg versus placebo in the treatment of endometriosis
Carbonell, J. L., Riverón, A. M., Leonard, Y., González, J., Heredia, B., & Sánchez, C. (2016) · Journal of Reproductive Health and Medicine · doi:10.1016/j.jrhm.2015.09.001 · Cited by 25 · see citing works
Taniguchi, F., Higaki, H., Azuma, Y., Deura, I., Iwabe, T., Harada, T., & Terakawa, N. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000343748 · Cited by 23 · see citing works
Zhang, H., Li, M., Wang, F., Liu, S., Li, J., Wen, Z., & Ζhao, X. (2009) · Gynecological Endocrinology · doi:10.3109/09513590903366988 · Cited by 23 · see citing works
Tjandrawinata, R. R., Tandrasasmita, O. M., Sutanto, A. M., et al. (2015) · International Journal of Women s Health · doi:10.2147/ijwh.s74552 · Cited by 23 · see citing works
Kocbek, V., Grandi, G., Blank, F., Wotzkow, C., Bersinger, N. A., Mueller, M. D., Kyo, S., & McKinnon, B. D. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw054 · Cited by 22 · see citing works
The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model
Çaycı, T., Akgül, E. Ö., Kurt, Y. G., Ceyhan, T., Aydın, İ., Öngürü, Ö., Yaman, H., Çakır, E., Yasar, M., Bilgi, C., et al. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2010.01482.x · Cited by 20 · see citing works
Leuprolide acetate for the treatment of endometriosis.
Miller, J. (1990) · PubMed · Cited by 19 · see citing works
Combination therapy with telmisartan and parecoxib induces regression of endometriotic lesions
Nenicu, A., Gu, Y. J., Körbel, C., Menger, M. D., & Laschke, M. W. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13874 · Cited by 19 · see citing works
Maltais, R., Trottier, A., Roy, J., Ayan, D. P., Bertrand, N., & Poirier, D. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.12.007 · Cited by 18 · see citing works
Scala, C., Maggiore, U. L. R., Barra, F., Venturini, P. L., & Ferrero, S. (2018) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2018.01.022 · Cited by 18 · see citing works
Self-citationZhang, J., Xu, Z., Dai, H.-Y., et al. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.05.009 · Cited by 17 · see citing works
Progression of bowel endometriosis during treatment with the oral contraceptive pill
Ferrero, S., Camerini, G. B., Venturini, P. L., Biscaldi, E., & Remorgida, V. (2010) · Gynecological Surgery · doi:10.1007/s10397-010-0610-3 · Cited by 14 · see citing works
Self-citationAn Oral GnRH Antagonist for Endometriosis — A New Drug for an Old Disease
Hornstein, M. D. (2017) · New England Journal of Medicine · doi:10.1056/nejme1706000 · Cited by 14 · see citing works
Dawood, M. Y., Wn, S., Dmowski, W. P., Rd, G., Rb, G., Girard, Y., Lemay, A., Dr, M., Nagamani, M., & Rj, P. (1990) · PubMed · Cited by 13 · see citing works
Therapeutic effects of mifepristone combined withGestrinone on patients with endometriosis
Xue, H.-L., Yu, N., Wang, J., Hao, W., Li, Y., & Liu, M. (2016) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.325.10772 · Cited by 13 · see citing works
Abdelsamie, A. S., Bey, E., Gargano, E. M., van Koppen, C. J., Empting, M., & Frotscher, M. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.08.030 · Cited by 12 · see citing works
Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model
Pınar, N., Karapınar, O. S., Özcan, O., Özgür, T., & Bayraktar, S. (2017) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12293 · Cited by 12 · see citing works
An overview of early drug development for endometriosis
Maggiore, U. L. R., & Ferrero, S. (2015) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2016.1126579 · Cited by 10 · see citing works
Self-citationmTor Inhibitors for the Treatment of Endometriosis
Barra, F., & Ferrero, S. (2018) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0043-124518 · Cited by 8 · see citing works
Self-citationEpigenetic Drugs in the Treatment of Endometriosis
Barra, F., & Ferrero, S. (2018) · Reproductive Sciences · doi:10.1177/1933719118765987 · Cited by 5 · see citing works
Self-citationThe use of retinoic acid for the treatment of endometriosis
Barra, F., & Ferrero, S. (2018) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-018-4774-9 · Cited by 5 · see citing works
Self-citationOsuga, Y., Seki, Y., Tanimoto, M., Kusumoto, T., Kudou, K., & Terakawa, N. (2017) · Endocrine Abstracts · doi:10.1530/endoabs.49.gp134 · Cited by 2 · see citing works
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Rethinking mechanisms, diagnosis and management of endometriosis
Chapron, C., Marcellin, L., Borghese, B., & Santulli, P. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0245-z · Cited by 1,084 · see citing works
Donnez, J., & Dolmans, M.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051085 · Cited by 182 · see citing works
Endometriosis, an Ongoing Pain—Step-by-Step Treatment
Mechsner, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020467 · Cited by 103 · see citing works
“Furthermore, in case of ongoing pain, also under GnRha, aromatase inhibitor treatment (with or without progestin, COC, or GnRH analog, significantly reduced pain compared with GnRH analog alone [18].”
BackgroundCaruso, S., Iraci, M., Cianci, S., Vitale, S. G., Fava, V., & Cianci, A. (2019) · Journal of Pain Research · doi:10.2147/jpr.s207599 · Cited by 73 · see citing works
A comprehensive review of hormonal and biological therapies for endometriosis: latest developments
Barra, F., Grandi, G., Tantari, M., Scala, C., Facchinetti, F., & Ferrero, S. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1581761 · Cited by 69 · see citing works
Self-citationImpact of surgery for endometriosis on the outcomes of in vitro fertilization
Ferrero, S., Gazzo, I., Crosa, M., Rosato, F. P., Barra, F., & Leone Roberti Maggiore, U. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2024.102496 · Cited by 17 · see citing works
Self-citationEndometrial receptivity in women with endometriosis
Racca, A., Bernabeu, A., Bernabeu, R., & Ferrero, S. (2024) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2023.102438 · Cited by 13 · see citing works
Self-citationFerrari, F., Valenti, G., Forte, S., Ardighieri, L., Iraci Sareri, M., Barra, F., Sartori, E., & Odicino, F. (2021) · Journal of Obstetrics and Gynaecology Research · doi:10.1111/jog.14635 · Cited by 8 · see citing works
Self-citation
- Authors
- Ferrero, S., Evangelisti, G., & Barra, F.
- Affiliations
- Ospedale Policlinico San Martino (IT)
- Corresponding author
- Ferrero, Simone
- Venue
- Expert Opinion on Pharmacotherapy
- Publisher
- Informa UK Limited
- Published
- 2018-07-03
- Volume
- 19
- Issue
- 10
- Pages
- 1109-1125
- ISSN
- 1465-6566 (ISSN-L)
- 1744-7666
- OpenAlex
- W2872842744
- Cited by
- 152
- References
- 201
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 17 · 2023: 21 · 2022: 19 · 2021: 30 · 2020: 19 · 2019: 16 · 2018: 7
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, pharmacotherapy, ovarian suppression, combined oral contraceptives, progestins, GnRH agonist, GnRH antagonist, aromatase inhibitors, pain management, drug development, clinical trials
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Drug Combinations, Endometriosis, Ethinyl Estradiol, Female, Hormone Antagonists, Humans, Gonadotropin-Releasing Hormone, Norpregnenes, Progestins, Aromatase Inhibitors, Pain Management
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