Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain
Open accessAbstract
Endometriosis is an estrogen-dependent chronic inflammatory disease associated with pelvic pain symptoms that are often severe, mainly dysmenorrhea, nonmenstrual pelvic pain and dyspareunia. This condition is also associated with peripheral and central sensitization. The current medical treatment options for endometriosis-associated pain are limited. Recently, the US FDA approved the novel, oral, nonpeptide gonadotropin-releasing hormone antagonist elagolix for the management of moderate to severe endometriosis-associated pain. Elagolix produces dose-dependent estrogen suppression, from partial suppression at lower doses to nearly full suppression at higher doses. This review article summarizes the current understanding of the pathophysiology of endometriosis, with a focus on the role of estrogen and the mechanisms of pain symptoms, and reviews the clinical development of elagolix in women with endometriosis-associated pain.
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The recommended treatment duration in women with normal liver function or mild hepatic impairment is up to 24 months with elagolix 150 mg once daily, and up to 6 months with 200 mg twice daily.
“As reported by Taylor et al. [107], the recommended treatment duration in women with normal liver function or mild hepatic impairment is up to 24 months with elagolix 150 mg once daily, and up to 6 months with 200 mg twice daily.”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [107]
Elagolix is rapidly absorbed after oral administration and its mean plasma half-life ranges from 2.4 to 6.3 h.
“Elagolix is rapidly absorbed after oral administration and its mean plasma half-life (t1/2) ranges from 2.4 to 6.3 h [99,107,110].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [107]
The pharmacokinetic properties of elagolix at 150 mg once daily and 200 mg twice daily do not appear to be affected, to a clinically meaningful extent, by body weight, body mass index, race/ethnicity or the presence of endometriosis.
“Overall, the pharmacokinetic properties of elagolix at 150 mg once daily and 200 mg twice daily do not appear to be affected, to a clinically meaningful extent, by body weight, body mass index, race/ethnicity or the presence of endometriosis [102,103,107].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [107]
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Role of Nuclear Steroid Receptors in Apoptosis
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Endometriosis Is Associated with Rare Copy Number Variants
Chettier, R., Ward, K. J., & Albertsen, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103968 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Donnez, J., & Dolmans, M.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051085 · Cited by 182 · see citing works
- Authors
- Taylor, H. S., Dun, E. C., & Chwalisz, K.
- Affiliations
- Yale University (US)
- AbbVie Inc., 1 North Waukegan Road, Bldg. AP4A-3, North Chicago, IL60064, USA
- Venue
- Pain Management
- Publisher
- Informa UK Limited
- Published
- 2019-08-22
- Volume
- 9
- Issue
- 5
- Pages
- 497-515
- ISSN
- 1758-1869 (ISSN-L)
- 1758-1877
- OpenAlex
- W2969537575
- Semantic Scholar
- 2f0bcb55f0902828a86d0f0f33c21aee02cb4b26
- Cited by
- 38
- References
- 98
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 6 · 2017: 2
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Pain Management (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- AbbVie Inc
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- elagolix, endometriosis-associated pain, GnRH antagonist, estrogen suppression, dysmenorrhea, dyspareunia, peripheral sensitization, central sensitization, endometriosis pathophysiology, clinical development
- MeSH terms
- Administration, Oral, Animals, Clinical Trials as Topic, Endometriosis, Estrogen Antagonists, Female, Humans, Hydrocarbons, Fluorinated, Gonadotropin-Releasing Hormone, Pain, Pyrimidines, Treatment Outcome, Pain Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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