The Outcome of 150 Babies Following the Treatment With Letrozole or Letrozole and Gonadotropins
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An abstract suggested higher risk of congenital cardiac and bone malformations in newborns with letrozole.
“The potential for teratogenic effects of letrozole has been raised, with an abstract suggesting higher risk of congenital cardiac and bone malformations in newborns. 240”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [240]
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History of Aromatase: Saga of an Important Biological Mediator and Therapeutic Target
Santen, R. J., Brodie, H. J., Simpson, E. R., Siiteri, P. K., & Brodie, A. M. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0016 · Cited by 442 · see citing works
Oktay, K., Hourvitz, A., Şahin, G., Öktem, Ö., Safro, B., Çil, A. P., & Bang, H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0962 · Cited by 418 · see citing works
“A recent abstract questioned the safety of the use of aromatase inhibitors for ovulation induction (27).”
BackgroundAssessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
Teede, H. J., Misso, M. L., Deeks, A. A., Moran, L. J., Stuckey, B. G. A., Wong, J. L. A., Norman, R. J., Costello, M. F., & Groups, O. B. O. T. G. D. (2011) · Medical Journal of Australia · doi:10.5694/mja11.10915 · Cited by 379 · see citing works
Tulandi, T., Martin, J., Al-Fadhli, R., Kabli, N., Forman, R., Hitkari, J., Librach, C., Greenblatt, E., & Casper, R. F. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.014 · Cited by 370 · see citing works
Ovulation induction in the management of anovulatory polycystic ovary syndrome
Balen, A. H. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.008 · Cited by 337 · see citing works
Blumenfeld, Z. (2007) · The Oncologist · doi:10.1634/theoncologist.12-9-1044 · Cited by 274 · see citing works
“by on January 28, 2010 www.TheOncologist.com Downloaded from for locomotor and cardiac malformations [ 80 ].”
BackgroundAromatase Inhibitors for Ovulation Induction
Casper, R. F., & Mitwally, M. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1923 · Cited by 272 · see citing works
Kyrou, D., Kolibianakis, E. M., Venetis, C. A., Papanikolaou, E. G. E., Bontis, J. N., & Tarlatzis, B. C. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.077 · Cited by 239 · see citing works
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome
Franik, S., Eltrop, S., Kremer, J. A. M., Kiesel, L., & Farquhar, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010287.pub3 · Cited by 208 · see citing works
Mild ovarian stimulation for IVF
Verberg, M. F. G., Macklon, N., Nargund, G., Frydman, R., Devroey, P., Broekmans, F. J., & Fauser, B. C. J. M. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn056 · Cited by 193 · see citing works
“Recent data have raised concerns regarding possible teratogeneity of aromatase inhibitors (Biljan et al., 2005) and ovarian stimulation is currently an off-label use again marketer's advice.”
BackgroundPolycystic ovary syndrome throughout a woman’s life
Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF), Bellver, J., Rodríguez-Tabernero, L., Robles, A., Muñoz, E., Martínez, F., Landeras, J., García-Velasco, J., Fontes, J., Álvarez, M., et al. (2018) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-017-1047-7 · Cited by 180 · see citing works
“A potential risk of teratogenic effects of letrozole was suggested in a preliminary report [80], but subsequent studies have discarded them [78].”
BackgroundRodgers, R. J., Reid, G., Koch, J., Deans, R., Ledger, W. J., Friedlander, M. L., Gilchrist, R. B., Walters, K. A., & Abbott, J. A. (2017) · Human Reproduction · doi:10.1093/humrep/dex027 · Cited by 144 · see citing works
Bosdou, J. K., Venetis, C. A., Kolibianakis, E. M., Toulis, K. A., Goulis, D. G., Zepiridis, L., & Tarlatzis, B. C. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr051 · Cited by 141 · see citing works
“Aromatase inhibitor use for ovarian stimulation has been associated with an increased incidence of congenital malformations (Biljan et al., 2005), although further published data seem to be reassuring (Tulandi et al.”
BackgroundWang, R., Kim, B. V., van Wely, M., JOHNSON, N. P., Costello, M., Zhang, H., Ng, E. H. Y., Legro, R. S., Bhattacharya, S., Norman, R. J., et al. (2017) · BMJ · doi:10.1136/bmj.j138 · Cited by 132 · see citing works
Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome
Sharpe, A., Morley, L. C., Tang, T. H., Norman, R. J., & Balen, A. H. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013505 · Cited by 133 · see citing works
Aromatase inhibitors for subfertile women with polycystic ovary syndrome
Franik, S., Kremer, J. A. M., Nelen, W. L. D. M., & Farquhar, C. M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010287.pub2 · Cited by 125 · see citing works
Costello, M., Misso, M. L., Balen, A. H., Boyle, J., Devoto, L., Garad, R. M., Hart, R. J., Johnson, L., Jordan, C., Legro, R. S., et al. (2018) · Human Reproduction Open · doi:10.1093/hropen/hoy021 · Cited by 125 · see citing works
“, 2014a,b) and concerns have been raised in an abstract on potential teratogenic effects (Biljan et al., 2005), which are as yet unconfirmed in peer-reviewed publications, yet this has sparked a series of warnings”
BackgroundSchoolcraft, W. B., Surrey, E. S., Minjarez, D. A., Stevens, J. M., & Gardner, D. K. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.02.013 · Cited by 103 · see citing works
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Casper, R. F., & Mitwally, M. F. (2011) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3182353d0f · Cited by 99 · see citing works
Ovulation induction in polycystic ovary syndrome
Tanbo, T. G., Mellembakken, J. R., Bjercke, S., Ring, E., Åbyholm, T., & Fedorcsák, P. (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13395 · Cited by 98 · see citing works
Aromatase inhibitors for PCOS: a systematic review and meta-analysis
Misso, M. L., Wong, J. L. A., Teede, H. J., Hart, R. J., Rombauts, L. J. F., Melder, A., Norman, R. J., & Costello, M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms003 · Cited by 96 · see citing works
“Initially, there was concern that the use of letrozole for infertility treatment may be associated with teratogenic effects (Biljan et al., 2005), but later publications did not find an association with fetal anomalies (Tulandi et al.”
BackgroundOvulation Induction in Polycystic Ovary Syndrome
Vause, T. D. R., Cheung, A. P., Cheung, A. P., Sierra, S., Claman, P., Graham, J., Guillemin, J.-A., Lapensée, L., Steward, S., Vause, T. D. R., et al. (2010) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34504-2 · Cited by 97 · see citing works
Badawy, A., Shokeir, T. A., ALLAM, A. F., & Abdel‐Hady, H. (2008) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340802638199 · Cited by 90 · see citing works
“(2005) suggested that the use of letrozole for infertility treatment might be associated with a higher risk of congenital cardiac and bone malformations in the newborns (7).”
BackgroundInfluentialYaralı́, H., Esinler, İ., Polat, M., Bozdağ, G., & Tıraş, B. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.04.057 · Cited by 86 · see citing works
The treatment of infertility in polycystic ovary syndrome: a brief update
Costello, M., Misso, M. L., Wong, J., Hart, R. J., Rombauts, L. J. F., Melder, A., Norman, R. J., & Teede, H. J. (2012) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2012.01448.x · Cited by 85 · see citing works
Fetal Safety of Letrozole and Clomiphene Citrate for Ovulation Induction
Forman, R., Gill, S., Moretti, M., Tulandi, T., Koren, G., & Casper, R. (2007) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32551-8 · Cited by 86 · see citing works
Comparison of different stimulation protocols used in in vitro fertilization: a review.
Shrestha, D., La, X., & Feng, H. L. (2015) · PubMed · doi:10.3978/j.issn.2305-5839.2015.04.09 · Cited by 83 · see citing works
Sharma, S., Ghosh, S., Singh, S., Chakravarty, A., Ganesh, A., Rajani, S., & Chakravarty, B. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108219 · Cited by 77 · see citing works
“The study presented by Biljan et al (2005) at ASRM meeting in which they compared 130 letrozole pregnancies with over 36,000 low risk spontaneous pregnancies, reported that letrozole might increase the risk of cardiac and bone anomalies in the newborns [6] however, the overall rate of major…”
BackgroundResultInfluentialDrugs in infertility and fetal safety
Elizur, S. E., & Tulandi, T. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.092 · Cited by 77 · see citing works
Badawy, A., Mosbah, A., & Shady, M. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.05.010 · Cited by 76 · see citing works
RetractedLetrozole for ovulation induction and controlled ovarian hyperstimulation
Pritts, E. A. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e32833beebf · Cited by 76 · see citing works
Roque, M., Tostes, A. C. I., Valle, M., Sampaio, M. A. C., & Geber, S. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1096337 · Cited by 67 · see citing works
“with letrozole, either alone or in combination with gonadotropin [32].”
BackgroundAromatase inhibitors in ovarian stimulation
Casper, R. F. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.05.025 · Cited by 68 · see citing works
Strategies to reduce multiple pregnancies due to ovulation stimulation
Dickey, R. P. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.008 · Cited by 64 · see citing works
“The safety of LET is currently under review because of a possible association with congenital anomalies (80).”
BackgroundFouda, U. M., & Sayed, A. M. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-84 · Cited by 65 · see citing works
A historical perspective of aromatase inhibitors for ovulation induction
Casper, R. F., & Mitwally, M. F. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.10.008 · Cited by 64 · see citing works
Hashim, H. A., Shokeir, T. A., & Badawy, A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.07.985 · Cited by 63 · see citing works
“Preliminary data (22) suggested an increased risk of congenital anomalies in letrozole-treated babies, whereas recent data from a retrospective trial (23) and a randomized study (24) contested these initial findings and supported its safety.”
ResultRetractedBadawy, A., Elnashar, A., & Totongy, M. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.013 · Cited by 63 · see citing works
“It suggested that the use of letrozole for infertility treatment might be associated with a higher risk of congenital cardiac malformations in the newborns (29).”
BackgroundRetractedFranik, S., Le, Q.-K., Kremer, J. A. M., Kiesel, L., & Farquhar, C. M. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010287.pub4 · Cited by 63 · see citing works
Mohsen, I. A., & Din, R. E. E. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2012.730569 · Cited by 59 · see citing works
“Despite the initial report of possibly increased congenital cardiac malformations [29], reassuring data were recently reported that show no such increase in the overall rates of malformations [30].”
BackgroundA brief update on the evidence supporting the treatment of infertility in polycystic ovary syndrome
Costello, M., Misso, M. L., Balen, A. H., Boyle, J. A., Devoto, L., Garad, R. M., Hart, R. J., Johnson, L., Jordan, C., Legro, R. S., et al. (2019) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.13051 · Cited by 58 · see citing works
Aromatase inhibitors for female infertility: a systematic review of the literature
Polyzos, N. P., Tzioras, S., Badawy, A., Valachis, A., Dritsas, C., & Mauri, D. N. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.06.008 · Cited by 57 · see citing works
Løssl, K., Andersen, A. N., Loft, A. G., Freiesleben, N. L. C., Bangsbøll, S., & Andersen, C. Y. (2006) · Human Reproduction · doi:10.1093/humrep/del221 · Cited by 55 · see citing works
“This will be important to evaluate in future studies because the increased risk of locomotor and cardiac malformations has recently been reported following the use of letrozole from days 3 to 7 for ovulation induction (Biljan et al., 2005).”
BackgroundThe Use of Aromatase Inhibitors for Ovulation Induction and Superovulation
Pavone, M. E., & Bulun, S. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1328 · Cited by 55 · see citing works
Gregoriou, O., Vlahos, N., Konidaris, S., Papadias, K., Botsis, D. S., & Creatsas, G. K. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.099 · Cited by 54 · see citing works
Tsiami, A. P., Goulis, D. G., Sotiriadis, A., & Kolibianakis, E. M. (2021) · HORMONES · doi:10.1007/s42000-021-00289-z · Cited by 54 · see citing works
Current evidence supporting "letrozole" for ovulation induction
Kar, S. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.117166 · Cited by 56 · see citing works
“Marinko Biljan presented an oral abstract at ASRM of 150 babies born after letrozole use.[3] This was compared with 36,000 spontaneous conceptions of the normal population.”
ResultInfluentialLøssl, K., Andersen, C. Y., Loft, A. G., Freiesleben, N. L. C., Bangsbøll, S., & Andersen, A. N. (2008) · Human Reproduction · doi:10.1093/humrep/den131 · Cited by 53 · see citing works
“The safety of aromatase inhibitors in assisted reproduction has been raised, as a higher prevalence of locomotor abnormalities was found among 150 children born after the use of letrozole for ovulation induction when compared to 36 000 children born after spontaneous conception in a non-infertile, low risk population…”
BackgroundThe effects of letrozole on ovarian stimulation for fertility preservation in cancer-affected women
Checa, M. Á., Corchado, A. R., Cuadri, M. E. S., González-Comadran, M., Brassesco, M., & Carreras, R. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.02.020 · Cited by 52 · see citing works
Tatsumi, T., Jwa, S. C., Kuwahara, A., et al. (2016) · Human Reproduction · doi:10.1093/humrep/dew280 · Cited by 52 · see citing works
“Letrozole use was associated with increased risks of congenital cardiac and musculoskeletal abnormalities in neonates according to a conference presentation reported in 2005 (Biljan et al., 2005; Novartis Pharmaceuticals Canada Inc., 2005; Tulandi et al., 2006), following which its manufacturers, Novartis Pharma, issu…”
BackgroundResultInfluentialInfertility and pregnancy after breast cancer: Current knowledge and future perspectives
Mastro, L. D., Catzeddu, T., & Venturini, M. (2006) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2006.05.004 · Cited by 47 · see citing works
Potential role of aromatase inhibitors in the treatment of endometriosis
Hashim, H. A. (2014) · International Journal of Women s Health · doi:10.2147/ijwh.s34684 · Cited by 46 · see citing works
“A poorly done abstract published by the ASRM in 2005, 73 which never resulted in a paper, raised concerns of increased cardiac and bone malformations in new-borns of letrozole-treated pregnancies compared with controls.”
New advances in ovulation induction
Kafy, S., & Tulandi, T. (2007) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3280c60c9a · Cited by 47 · see citing works
Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation
Bedaiwy, M. A., Forman, R., Mousa, N. A., Inany, H., & Casper, R. F. (2006) · Human Reproduction · doi:10.1093/humrep/del273 · Cited by 46 · see citing works
Lee, V. C. Y., Chan, C. C. W., Ng, E. H. Y., Yeung, W. S. B., & Ho, P. C. (2011) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.05.012 · Cited by 44 · see citing works
“One major concern of using letrozole in ovulation induction or ovarian stimulation is its possible teratogenicity (Biljan et al. 2005).”
BackgroundRisk of foetal harm with letrozole use in fertility treatment: a systematic review and meta-analysis
Pundir, J., Achilli, C., Bhide, P., Sabatini, L., Legro, R. S., Rombauts, L. J. F., Teede, H. J., Coomarasamy, A., Zamora, J., & Thangaratinam, S. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa055 · Cited by 45 · see citing works
Aromatase inhibitors for ovulation induction and ovarian stimulation
Lee, V. C. Y., & Ledger, W. J. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04006.x · Cited by 42 · see citing works
Hashim, H. A., RAKHAWY, M. E., & Elaal, I. A. (2011) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2011.01346.x · Cited by 41 · see citing works
“Preliminary data (25) suggested an increased risk of congenital anomalies in letrozole-treated babies, whereas recent data from a retrospective trial (26) and a randomized trial (27) have contested these initial findings and supported its safety.”
ResultBülow, N. S., Skouby, S. O., Warzecha, A. K., Udengaard, H., Andersen, C. Y., Holt, M. D., Grøndahl, M. L., Andersen, A. N., Sopa, N., Englund, A. L. M., et al. (2021) · Human Reproduction · doi:10.1093/humrep/deab249 · Cited by 40 · see citing works
Use of aromatase inhibitors in practice of gynecology
Usluoğullari, B., Duvan, C. Z., & Usluoğulları, C. A. (2015) · Journal of Ovarian Research · doi:10.1186/s13048-015-0131-9 · Cited by 40 · see citing works
“7 years) [63].”
Hashim, H. A., Foda, O., & Ghayaty, E. (2015) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.12673 · Cited by 37 · see citing works
“A potential safety concern regarding the newborns was initially raised (40); however, recent data have supported its safety (41,42).”
ResultPrinciples of Human Teratology: Drug Chemical and Infectious Exposure
Wilson, R. D., Wilson, R. D., Johnson, J.-A., et al. (2007) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32668-8 · Cited by 36 · see citing works
Ebrahimi, M., Akbari-Asbagh, F., & Ghalandar-Attar, M. (2017) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.15.2.101 · Cited by 35 · see citing works
“An Initial study has suggested an increase in cardiac, musculoskeletal system malformations and low birth weight in offspring of mothers who conceived with letrozole (26).”
BackgroundManagement of anovulatory infertility
Li, R., & Ng, E. H. Y. (2012) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2012.05.004 · Cited by 33 · see citing works
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Bülow, N. S., Holt, M. D., Skouby, S. O., Petersen, K. B., Englund, A. L. M., Pinborg, A. B., & Macklon, N. S. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.12.006 · Cited by 34 · see citing works
The use of aromatase inhibitors in in vitro fertilization
García-Velasco, J. A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.09.042 · Cited by 32 · see citing works
Hashim, H. A., Mashaly, A. E.-M., & Badawy, A. (2010) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1566-2 · Cited by 32 · see citing works
“[24] suggested an increased risk of congenital anomalies in letrozole treated babies, whereas recent data from retrospective and prospective trials [25, 26] have contested these initial Wndings and supported the safety of letrozole compared to traditional ovulation induction treatment.”
ResultRetractedDehbashi, S., Dehbashi, S., Kazerooni, T., Robati, M., Alborzi, S., & Shadman, A. (2009) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 32 · see citing works
Costello, M., Garad, R. M., Hart, R. J., Homer, H. A., Johnson, L., Jordan, C., Mocanu, E. V., Qiao, J., Rombauts, L. J. F., Teede, H. J., et al. (2019) · Medical Sciences · doi:10.3390/medsci7090095 · Cited by 32 · see citing works
“Initially, there were concerns regarding the potential teratogenic effect of letrozole for infertility treatment [22] but a recent review of the published literature did not find an increased risk of foetal anomalies with letrozole [17].”
BackgroundThe Clinical Manifestations of Polycystic Ovary Syndrome (PCOS) and The Treatment Options
Karkera, S., Agard, E., & Sankova, L. (2023) · European Journal of Biology and Medical Science Research · doi:10.37745/ejbmsr.2013/vol11n15791 · Cited by 34 · see citing works
Liu, A., Zheng, C., Lang, J., & Chen, W. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12393 · Cited by 31 · see citing works
Current Therapeutic Options for Controlled Ovarian Stimulation in Assisted Reproductive Technology
Racca, A., Drakopoulos, P., Neves, A. R., & Polyzos, N. P. (2020) · Drugs · doi:10.1007/s40265-020-01324-w · Cited by 33 · see citing works
Nakasuji, T., Kawai, K., Ishikawa, T., et al. (2019) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12263 · Cited by 30 · see citing works
Ovulation Induction in Polycystic Ovary Syndrome
Vause, T. D. R., Cheung, A. P., Sierra, S., Claman, P., Graham, J., Guillemin, J., Lapensée, L., Steward, S., Vause, T. D. R., & Wong, B. C.-M. (2010) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2010.07.001 · Cited by 28 · see citing works
“These findings reported a higher incidence of both cardiac and bone abnormalities in the letrozole group [67].”
BackgroundAromatase inhibitors for subfertile women with polycystic ovary syndrome
Franik, S., Kremer, J. A. M., Nelen, W. L. D. M., et al. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010287 · Cited by 30 · see citing works
Potential of Aromatase Inhibitors for Ovulation and Superovulation Induction in Infertile Women
Mitwally, M. F., & Casper, R. F. (2006) · Drugs · doi:10.2165/00003495-200666170-00001 · Cited by 29 · see citing works
Ovulation triggers in anovulatory women undergoing ovulation induction
George, K., Nair, R., & Tharyan, P. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006900.pub2 · Cited by 28 · see citing works
Shapira, M., Orvieto, R., Lebovitz, O., Nahum, R., Aizer, A., Segev-Zahav, A., & Haas, J. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00666-z · Cited by 27 · see citing works
Hashim, H. A. (2012) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2261-2 · Cited by 28 · see citing works
“According to an abstract published by the American Society for Reproductive Medicine (ASRM) in 2005 [61], the use of letrozole for ovulation induction has been discouraged, since there was a signiWcant increase in congenital cardiac and bone malformations in newborns in letrozoletreated pregnancies compared with contr…”
Treatment Strategies for the Infertile Polycystic Ovary Syndrome Patient
Tannus, S., Burke, Y. Z., & Kol, S. (2015) · Women s Health · doi:10.2217/whe.15.40 · Cited by 27 · see citing works
Yu, Q., Hu, S., Wang, Y., et al. (2019) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0461-3 · Cited by 27 · see citing works
Yland, J. J., Chiu, Y., Rinaudo, P. F., Hsu, J., Hernán, M. Á., & Hernández–Dı́az, S. (2022) · Human Reproduction · doi:10.1093/humrep/deac005 · Cited by 23 · see citing works
ART: iatrogenic multiple pregnancy?
Verberg, M. F. G., Macklon, N., Heijnen, E., & Fauser, B. C. J. M. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.09.011 · Cited by 22 · see citing works
Malloch, L., & Rhoton-Vlasak, A. S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.040 · Cited by 22 · see citing works
Role of androgens in the treatment of patients with low ovarian response
Feigenberg, T., Simon, A., Ben‐Meir, A., Gielchinsky, Y., & Laufer, N. (2009) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2009.09.012 · Cited by 21 · see citing works
“Recently, an abstract was presented during a meeting of the American Society for Reproductive Medicine (ASRM) (Biljan et al., 2005), raising the concern that the use of letrozole for infertility treatment might be associated with a higher risk of congenital cardiac and bone malformations in newborns.”
BackgroundElassar, A. A., Engmann, L., NULSEN, J. C., & Benadiva, C. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.03.103 · Cited by 19 · see citing works
Therapeutic options in the polycystic ovary syndrome
Bhathena, R. K. (2007) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610601113797 · Cited by 18 · see citing works
“The possible teratogenicity of letrozole needs to be carefully evaluated (Biljan et al. 2005).”
BackgroundPhenotypic and pharmacogenetic aspects of ovulation induction in WHO II anovulatory women
Overbeek, A., & Lambalk, C. B. (2009) · Gynecological Endocrinology · doi:10.1080/09513590802571118 · Cited by 17 · see citing works
“Nevertheless, in an abstract presentation on the 2005 annual ASRM meeting, the authors reported an increased incidence in cardiac and locomotor malformations in the letrozole group [43].”
BackgroundSene, A. A., Ghorbani, S., & Ashrafi, M. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13644 · Cited by 17 · see citing works
“letrozole compared with 36 005 newborns from spontaneous pregnancies, which resulted in the prohibition of letrozole use to induce ovulation in many countries.(6) However, there were significant methodological errors in this study.”
BackgroundResultIs the use of letrozole to induce ovulation teratogenic?
Gill, S. K., Moretti, M. E., & Koren, G. (2008) · PubMed Central · Cited by 20 · see citing works
Ben‐Haroush, A., Farhi, J., Ben‐Aharon, I., et al. (2011) · PubMed · Cited by 16 · see citing works
Lambertini, M., Pescio, M. C., Viglietti, G., Goldrat, O., Mastro, L. D., Anserini, P., & Demeestere, I. (2016) · Expert Review of Quality of Life in Cancer Care · doi:10.1080/23809000.2017.1270760 · Cited by 16 · see citing works
“increased risk of congenital cardiac and musculoskeletal anomalies in the newborns [52]; hence, its manufacturer issued a warning to physicians to stop using letrozole for”
BackgroundEffects of a non-steroidal aromatase inhibitor on ovarian function in cattle
Yapura, J., Mapletoft, R. J., Singh, J. K., Pierson, R. A., Naile, J. E., Giesy, J. P., Chang, H., Higley, E. B., Hecker, M., & Adams, G. P. (2011) · Reproduction Fertility and Development · doi:10.1071/rd11239 · Cited by 16 · see citing works
“[133].”
The Risk of Congenital Anomalies by Fertility Treatment Modality
Chung, E. H., Harris, B. S. H., Muasher, S. J., et al. (2021) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000855 · Cited by 15 · see citing works
“In 2005, one retrospective analysis (N = 150) raised concerns for increased incidence of cardiovascular and skeletal anomalies in letrozole-conceived pregnancies compared with natural pregnancies.(75) Since then, numerous concerns have been voiced regarding the study's methodology.”
BackgroundOvulation triggers in anovulatory women undergoing ovulation induction
George, K., Kamath, M. S., Nair, R., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006900.pub3 · Cited by 14 · see citing works
Fatum, M., McVeigh, E., & Child, T. J. (2013) · Human Fertility · doi:10.3109/14647273.2013.800650 · Cited by 14 · see citing works
“A small study presented as an Abstract to the American Society for Reproductive Medicine meeting in 2005 suggested that Letrozole could cause serious foetal anomalies (Biljan et al., 2005).”
BackgroundNo. 362-Ovulation Induction in Polycystic Ovary Syndrome
Smithson, D. S., Vause, T. D. R., & Cheung, A. P. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2017.12.004 · Cited by 14 · see citing works
Fouda, U. M., & Sayed, A. M. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.579661 · Cited by 13 · see citing works
- Authors
- Biljan, M. M., Hemmings, R., & Brassard, N.
- Affiliations
- St Mary's Hospital Centre (CA)
- ORCID
- Hemmings, R.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 84
- Pages
- S95
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2115337926
- Cited by
- 206
- References
- 0
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 6 · 2012: 17
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- letrozole, gonadotropins, ovulation induction, aromatase inhibitors, pregnancy outcomes, infertility treatment, assisted reproduction
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