The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrom patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function
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Objective To evaluate endothelial function with flow-mediated dilatation (FMD) and carotid intima media thickness (IMT) in young nonobese polycystic ovary syndrome (PCOS) patients.Design Prospective case-control study.Setting Healthy volunteers and nonobese young PCOS patients in clinical research.Patient(s) Thirty-nine PCOS patients with mean age of 22.82 +/- 5.53 years and 30 body mass index- and age-matched healthy controls were evaluated.Intervention(s) Insulin resistance was calculated with area under the curve, quantitative insulin sensitivity check, and the Matsuda index. Endothelial function was assessed with FMD and carotid IMT by ultrasonography.Main outcome measure(s) Antropometric, hormonal, biochemical (insulin and glucose, tumor necrosis factor-alpha, hs-c-reactive protein, and homocysteine levels, and so forth), FMD, and IMT were measured.Result(s) There was a significant insulin resistance in PCOS patients. Serum FSH, total and free testosterone, cortisol, androstenedione, and DHEA-S levels of PCOS patients were also higher than control subjects, but we could not find any significant difference in terms of endothelial function determined with FMD.Conclusion(s) Existence of insulin resistance alone may not be an adequate factor for deterioration of endothelial function and carotid IMT in young, nonobese patients with PCOS. Other factors such as duration of insulin resistance, older age, presence of obesity, and inflammatory markers may play an important role in this process.
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Young women and adolescents with PCOS have early atherosclerotic cardiovascular disease, including increased carotid intimal medial thickness and carotid plaque.
“Young women and adolescents with PCOS have been shown to have early atherosclerotic CVD, including increased carotid intimal medial thickness and carotid plaque.86, 87, 88, 89”
From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [88]
The Flow-Mediated Dilation and Carotid IMT results (page unavailable) report that carotid IMT did not differ between young, nonobese PCOS patients and controls; the Discussion reiterates this contrary finding. The paper mentions carotid plaque only as something to exclude from IMT measurements, not as an increased finding in PCOS patients. (LLM, conf=0.90)
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Research works printed but not linked: 1
- Burghen GA, Givens JR, Kitabachi AE. Correlation of hyperandrogen- ism with hyperinsulinemia in polycystic ovarian disease. J Clin Endocri- nol Metab 1980;50:113-6.
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Sorted by citations
Meyer, M. L., Malek, A. M., Wild, R. A., Korytkowski, M. T., & Talbott, E. O. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr046 · Cited by 175 · see citing works
Vine, D., Ghosh, M., Wang, T., & Bakal, J. (2024) · CJC Open · doi:10.1016/j.cjco.2023.12.010 · Cited by 53 · see citing works
- Authors
- Arikan, S., Akay, H., Bahceci, M., Tuzcu, A., & Gokalp, D.
- Affiliations
- Dicle University (TR)
- Corresponding author
- Arikan, Senay
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 91
- Issue
- 2
- Pages
- 450-455
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2072241352
- Cited by
- 49
- References
- 37
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 5 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 9
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- polycystic ovary syndrome, endothelial function, flow-mediated dilation, carotid intima-media thickness, insulin resistance, inflammatory markers, androgens, cardiovascular risk
- MeSH terms
- Adult, Age Factors, Body Weight, Brachial Artery, Carotid Arteries, Endothelium, Vascular, Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Prospective Studies, Regional Blood Flow, Ultrasonography, Vasodilation, Biomarkers, Body Mass Index, Case-Control Studies, Tunica Intima, Tunica Media, Adiposity, Waist Circumference, Young Adult
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