Vascular Dysfunction and Metabolic Parameters in Polycystic Ovary Syndrome
Abstract
CONTEXT: Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and the metabolic syndrome; however, the cardiovascular (CV) manifestations of PCOS remain unclear. OBJECTIVE: The objective of this study was to examine the relationships between IR, metabolic parameters, androgens, and markers of early CV disease in PCOS. DESIGN: We conducted an observational study examining noninvasive markers of early CV disease in women with PCOS including structural [carotid intimal media thickness (IMT)] and functional measures (arterial function with pulse wave velocity and endothelial function with brachial arterial flow-mediated vasodilation). Metabolic parameters included insulin and glucose during an oral glucose tolerance test and lipid and androgen levels. SETTING: Participants were recruited from the general community. PATIENTS: Eighty overweight women with PCOS who were nonsmokers and not on oral contraceptives or other medications known to affect IR participated in the study. RESULTS: Stepwise regression analysis showed that after adjustment for age and body mass index, IMT was significantly correlated with blood pressure (BP) load (P = 0.03) and inversely with dehydroepiandrosterone sulfate (DHEAS) (P = 0.01). After correction for androgen status, IMT was correlated with fasting glucose and area under curve (AUC) insulin. Flow-mediated vasodilation was inversely related to lipids (P = 0.02), whereas pulse wave velocity was related to BP (P < 0.001), AUC insulin (P = 0.04), and AUC glucose (P = 0.035). CONCLUSION: In overweight women with PCOS, insulin resistance and BP interacted negatively with arterial structural and functional measures. DHEAS correlated inversely with arterial structure, suggesting possible cardioprotective effects of endogenous DHEAS in women with PCOS. Additional research is needed to clarify these findings.
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Obesity exacerbates the increased CVD risk factors and clinical signs of atherosclerosis in women with PCOS.
“which are all exacerbated by obesity.”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [29]
Women with PCOS have increased individual risk factors for CVD and clinical signs of atherosclerosis.
“individual risk factors for CVD and clinical signs of atherosclerosis, 29,30”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [29]
In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD have been noted and are related to IR and obesity.
“In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD 29,30,83 have been noted and are related to IR and obesity. 84-89”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [29]
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- Authors
- Meyer, C., McGrath, B. P., Cameron, J., Kotsopoulos, D., & Teede, H. J.
- Affiliations
- Dandenong Hospital (AU)
- Corresponding author
- Teede, H. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-08-01
- Volume
- 90
- Issue
- 8
- Pages
- 4630-4635
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1992054212
- Cited by
- 101
- References
- 38
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 5
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- polycystic ovary syndrome, insulin resistance, cardiovascular risk, carotid intima-media thickness, flow-mediated dilation, pulse wave velocity, endothelial function, arterial stiffness, dehydroepiandrosterone sulfate, blood pressure, fasting blood glucose, serum lipids, metabolic syndrome, overweight women
- MeSH terms
- Adolescent, Adult, Androgens, Carotid Artery Diseases, Endothelium, Vascular, Female, Humans, Insulin Resistance, Middle Aged, Obesity, Polycystic Ovary Syndrome, Pulsatile Flow, Regression Analysis, Ultrasonography, Vasodilation, Blood Pressure Monitoring, Ambulatory
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