Overweight Women with Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease

Meyer, C.; McGrath, B. P.; Teede, H. J.

doi:10.1210/jc.2005-0011

Cited by 273Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

Overweight Women with Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease

Meyer, C., McGrath, B. P., Teede, H. J.·2005·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2005-0011

Open this paper in CoChat — free account

Abstract

CONTEXT: Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR) and the metabolic syndrome. There are no adequate data demonstrating significantly increased cardiovascular disease (CVD) mortality. In the absence of clinical outcome studies, surrogate markers of early CVD can provide insight into early CVD. OBJECTIVE: The aim of this study was to clarify whether overweight women with PCOS have an increased prevalence of cardiovascular risk factors and early CVD, compared with age- and body mass index-matched controls, to determine the contribution of PCOS per se to CVD status. DESIGN AND PATIENTS: This was a case control study of 100 overweight women with PCOS and 20 subjects of similar body mass index and age. MAIN OUTCOME MEASURES: Noninvasive markers of early CVD [carotid intimal media thickness, pulse wave velocity (PWV), and brachial arterial flow-mediated vasodilation] were measured. Metabolic parameters studied included insulin, glucose, C-reactive protein, lipids, and androgens. RESULTS: Subjects with PCOS had elevated testosterone (2.5 +/- 0.2 vs. 1.3 +/- 0.1 nmol/liter), dehydroepiandrosterone sulfate (4.9 +/- 0.3 vs. 3.6 +/- 0.4 mmol/liter), fasting insulin (19.6 +/- 1.4 vs. 6.8 +/- 0.8 microU/ml), and homeostasis model assessment of IR (4.1 +/- 0.3 vs. 1.3 +/- 0.2), compared with controls. In addition, those with PCOS had elevated cholesterol (5.1 +/- 0.1 vs. 4.6 +/- 0.2 mmol/liter) and triglycerides (1.4 +/- 0.1 vs. 0.9 +/- 0.1 mmol/liter), whereas there were no differences in either C-reactive protein or 24-h ambulatory blood pressure parameters. Subjects with PCOS also had increased arterial stiffness (PWV, 7.4 +/- 0.1 vs. 6.6 +/- 0.2 m/sec) and endothelial dysfunction (flow-mediated vasodilation, 9.8 +/- 0.4 vs. 13.3 +/- 0.9), compared with controls. There was no difference in mean intimal media thickness between the groups. Stepwise regression in PCOS subjects showed that IR and lipids were independent predictors of PWV. CONCLUSION: Overweight women with PCOS have increased cardiovascular risk factors and evidence of early CVD, compared with weight-matched controls, potentially related to IR.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/jc.2005-0011

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Women with PCOS have increased individual risk factors for CVD and clinical signs of atherosclerosis.
“individual risk factors for CVD and clinical signs of atherosclerosis, 29,30”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [30]
Obesity exacerbates the increased CVD risk factors and clinical signs of atherosclerosis in women with PCOS.
“which are all exacerbated by obesity.”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [30]
In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD have been noted and are related to IR and obesity.
“In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD 29,30,83 have been noted and are related to IR and obesity. 84-89”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [30]
IR is a key aetiological feature in PCOS, worsening the reproductive and metabolic features, type 2 diabetes and CVD risk.
“IR is a key aetiological feature in PCOS, worsening the reproductive and metabolic features, type 2 diabetes and CVD risk. 30,99,100”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [30]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742 · see citing works
Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
Laurent, S., Boutouyrie, P., Asmar, R., Gautier, I., Laloux, B., Guize, L., Ducimetiere, P., & Benetos, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.5.1236 · Cited by 3,856 · see citing works
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,761 · see citing works
Clinical assessment of body hair growth in women.
Ferriman, D., & Gallwey, J. D. (1961) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem-21-11-1440 · Cited by 2,556 · see citing works
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967 · see citing works
Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients
Boutouyrie, P., Tropeano, A., Asmar, R. G., Gautier, I., Bénétos, A., Lacolley, P. J., & Laurent, S. (2002) · Hypertension · doi:10.1161/hy0102.099031 · Cited by 1,745 · see citing works
Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.
Celermajer, D. S., Sørensen, K. E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J. T. C., & Deanfield, J. E. (1993) · Circulation · doi:10.1161/01.cir.88.5.2149 · Cited by 1,532 · see citing works
Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients
Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1111 · Cited by 1,493 · see citing works
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/er.18.6.774 · Cited by 1,167 · see citing works
Cardiovascular disease in women with polycystic ovary syndrome at long‐term follow‐up: a retrospective cohort study
Wild, S., Pierpoint, T., McKeigue, P., & Jacobs, H. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01000.x · Cited by 970 · see citing works
Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
McVeigh, G. E., Brennan, G. M., Johnston, G. D., McDermott, B. J., McGrath, L. T., Henry, W. R., Andrews, J. W., & Hayes, J. R. (1992) · Diabetologia · doi:10.1007/bf00429099 · Cited by 916 · see citing works
Passive Smoking and Impaired Endothelium-Dependent Arterial Dilatation in Healthy Young Adults
Celermajer, D. S., Adams, M. R., Clarkson, P., Robinson, J. T. C., McCredie, R. J., Donald, A. E., & Deanfield, J. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601183340303 · Cited by 907 · see citing works
Insulin resistance and hypersecretion in obesity: European Group for the Study of Insulin Resistance (EGIR)
Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119628 · Cited by 898 · see citing works
A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome*
NESTLER, J. E., POWERS, L. P., MATT, D. W., STEINGOLD, K. A., PLYMATE, S. R., RITTMASTER, R. S., CLORE, J. N., & BLACKARD, W. G. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-83 · Cited by 815 · see citing works
Central Pulse Pressure and Mortality in End-Stage Renal Disease
Safar, M. E., Blacher, J., Pannier, B., Guérin, A. P., Marchais, S. J., Guyonvarc’h, P.-M., & London, G. M. (2002) · Hypertension · doi:10.1161/hy0202.098325 · Cited by 806 · see citing works
Polycystic Ovary Syndrome (PCOS): Arguably the Most Common Endocrinopathy Is Associated with Significant Morbidity in Women
Carmina, E., & Lobo, R. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5803 · Cited by 528 · see citing works
Evidence for Association Between Polycystic Ovary Syndrome and Premature Carotid Atherosclerosis in Middle-Aged Women
Talbott, E. O., Guzick, D. S., Sutton-Tyrrell, K., McHugh-Pemu, K. P., Zborowski, J. V., Remsberg, K. E., & Kuller, L. H. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.11.2414 · Cited by 511 · see citing works
Mortality of Women with Polycystic Ovary Syndrome at Long-term Follow-up
Pierpoint, T., McKeigue, P. M., Isaacs, A. J., Wild, S. H., & Jacobs, H. S. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00035-3 · Cited by 504 · see citing works
Lipoprotein Lipid Concentrations and Cardiovascular Risk in Women with Polycystic Ovary Syndrome
Wild, R. A., Painter, P. C., Coulson, P. B., CARRUTH, K. B., & Ranney, G. B. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-61-5-946 · Cited by 480 · see citing works
Polycystic Ovary Syndrome Is Associated With Endothelial Dysfunction
Paradisi, G., Steinberg, H. O., Hempfling, A., Cronin, J., Brechtel, G., Shepard, M. K., & Baron, A. (2001) · Circulation · doi:10.1161/01.cir.103.10.1410 · Cited by 476 · see citing works
Endothelial Dysfunction Is Detectable in Young Normotensive First-Degree Relatives of Subjects With Type 2 Diabetes in Association With Insulin Resistance
Balletshofer, B. M., Rittig, K., Enderle, M. D., Volk, A., Maerker, E., Jacob, S., Matthaei, S., Kristian, R. E. T. T., & Häring, H. U. (2000) · Circulation · doi:10.1161/01.cir.101.15.1780 · Cited by 437 · see citing works
Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus
Ovalle, F., & Azziz, R. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03111-4 · Cited by 428 · see citing works
Insulin Causes Endothelial Dysfunction in Humans: Sites and Mechanisms
Arcaro, G., Cretti, A., Balzano, S., Lechi, A., Muggeo, M., Bonora, E., & Bonadonna, R. C. (2002) · Circulation · doi:10.1161/hc0502.103333 · Cited by 407 · see citing works
Reproducibility of In Vivo Carotid Intima-Media Thickness Measurements
Kanters, S. D. J. M., Algra, A., van Leeuwen, M. S., & Banga, J.-D. (1997) · Stroke · doi:10.1161/01.str.28.3.665 · Cited by 365 · see citing works
Relation of extent of extracranial carotid artery atherosclerosis as measured by B-mode ultrasound to the extent of coronary atherosclerosis.
Wofford, J. L., Kahl, F. R., Howard, G., McKinney, W. M., Toole, J. F., & Crouse, J. R. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.6.1786 · Cited by 335 · see citing works
Early Impairment of Endothelial Structure and Function in Young Normal-Weight Women with Polycystic Ovary Syndrome
Orio, F., Palomba, S., Cascella, T., Simone, B. D., Biase, S. D., Russo, T., Labella, D., Zullo, F., Lombardi, G., & Colao, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031867 · Cited by 330 · see citing works
Adverse Lipid and Coronary Heart Disease Risk Profiles in Young Women with Polycystic Ovary Syndrome: Results of a Case-Control Study
Talbott, E. O., Clerici, A., Berga, S. L., Kuller, L. H., Guzick, D. S., Detre, K. M., Daniels, T. L., & Engberg, R. A. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00010-9 · Cited by 312 · see citing works
Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*
Hollenbeck, C. B., & Reaven, G. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1169 · Cited by 306 · see citing works
Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome: Relationship with Insulin Resistance and Low-Grade Chronic Inflammation
Tarkun, İ., ARSLAN, B., Cantürk, Z., Türemen, E., Şahı̇n, T., & Duman, C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0751 · Cited by 297 · see citing works
Vascular dysfunction in diabetes mellitus
Feener, E. P., & King, G. L. (1997) · The Lancet · doi:10.1016/s0140-6736(97)90022-2 · Cited by 287 · see citing works
Non-invasive measurements of arterial structure and function: repeatability, interrelationships and trial sample size
Liang, Y., Teede, H. J., Kotsopoulos, D., Shiel, L. M., Cameron, J. D., Dart, A. M., & McGrath, B. P. (1998) · Clinical Science · doi:10.1042/cs0950669 · Cited by 277 · see citing works
Self-citation
Altered Vascular Function in Young Women with Polycystic Ovary Syndrome
Kelly, C. J., Speirs, A., Gould, G. W., Petrie, J. R., Lyall, H., & Connell, J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8199 · Cited by 257 · see citing works
Defects in beta-cell function in functional ovarian hyperandrogenism
O’Meara, N., Blackman, J. D., Ehrmann, D. A., Barnes, R. B., Jaspan, J. B., Rosenfield, R. L., & Polonsky, K. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.5.8496316 · Cited by 243 · see citing works
Insulin resistance and the endothelium
Hsueh, W. A., Lyon, C. J., & Quiñones, M. J. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.02.042 · Cited by 234 · see citing works
Carotid atherosclerosis in women with polycystic ovary syndrome: Initial results from a case-control study
Guzick, D. S., Talbott, E. O., Sutton-Tyrrell, K., Herzog, H. C., Kuller, L. H., & Wolfson, S. K. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70665-8 · Cited by 210 · see citing works
Estimation of arterial stiffness, compliance, and distensibility from M-mode ultrasound measurements of the common carotid artery.
Gamble, G. D., Zorn, J., Sanders, G. P., MacMahon, S. W., & Sharpe, N. (1994) · Stroke · doi:10.1161/01.str.25.1.11 · Cited by 204 · see citing works
Insulin, insulin sensitivity and hypertension
Ferrari, P., & Weidmann, P. U. (1990) · Journal of Hypertension · doi:10.1097/00004872-199006000-00001 · Cited by 184 · see citing works
Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI‐1) activity in lean women with and without the polycystic ovary syndrome
Sampson, M., Kong, C. H., Patel, A. K., Unwin, R. J., & Jacobs, H. S. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.00863.x · Cited by 184 · see citing works
Elevated ambulatory day-time blood pressure in women with polycystic ovary syndrome: a sign of a pre-hypertensive state?
Holte, J., Gennarelli, G., Berne, C., Bergh, T., & Lithell, H. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019028 · Cited by 181 · see citing works
Polycystic ovary syndrome: lack of hypertension despite profound insulin resistance
Zimmermann, S., Phillips, R. A., Dunaif, A. E., Finegood, D. T., Wilkenfeld, C., Ardeljan, M., Gorlin, R., & Krakoff, L. R. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.2.1639952 · Cited by 146 · see citing works
Obesity, lipids, cardiovascular risk, and androgen excess
Wild, R. A. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80056-4 · Cited by 145 · see citing works
Glucose-to-Insulin Ratio Rather than Sex Hormone-Binding Globulin and Adiponectin Levels Is the Best Predictor of Insulin Resistance in Nonobese Women with Polycystic Ovary Syndrome
Ducluzeau, P., Cousin, P., Malvoisin, E., Bornet, H., Vidal, H., Laville, M., & PUGEAT, M. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030219 · Cited by 137 · see citing works
The biological variation of testosterone and sex hormone-binding globulin (SHBG) in polycystic ovarian syndrome: implications for SHBG as a surrogate marker of insulin resistance.
Jayagopal, V., Kilpatrick, E. S., Jennings, P. E., Hepburn, D. A., & Atkin, S. L. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020557 · Cited by 137 · see citing works
Normal Endothelial Function Despite Insulin Resistance in Healthy Women with the Polycystic Ovary Syndrome
Mather, K. J., Verma, S., Corenblum, B., & Anderson, T. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.5.6587 · Cited by 123 · see citing works
Troglitazone Therapy Improves Endothelial Function to Near Normal Levels in Women with Polycystic Ovary Syndrome
Paradisi, G., Steinberg, H. O., Shepard, M. K., Brechtel, G., & Baron, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020386 · Cited by 111 · see citing works
The influence of body weight on lipoprotein lipids in patients with polycystic ovary syndrome
Wild, R. A., & Bartholomew, M. J. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(88)80099-1 · Cited by 93 · see citing works
Sex hormone-binding globulin levels and cardiovascular risk factors in morbidly obese subjects before and after weight reduction induced by diet or malabsorptive surgery
Mingrone, G., Greco, A., Giancaterini, A., Scarfone, A., Castagneto, M., & Pugeat, M. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00667-0 · Cited by 89 · see citing works
Intima-media thickness of elastic and muscular arteries of young women with polycystic ovaries
LAKHANI, K. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.04.007 · Cited by 88 · see citing works

Flagged first, then by citations

Sorted by citations

Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline
Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2350 · Cited by 1,919 · see citing works
Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan
Teede, H., Deeks, A., & Moran, L. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-41 · Cited by 1,565 · see citing works
Self-citation
Impaired Glucose Tolerance, Type 2 Diabetes and Metabolic Syndrome in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Moran, L. J., Misso, M. L., Wild, R. A., & Norman, R. J. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq001 · Cited by 1,108 · see citing works
Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp
Stepto, N. K., Cassar, S., Joham, A. E., Hutchison, S. K., Harrison, C. L., Goldstein, R. F., & Teede, H. J. (2013) · Human Reproduction · doi:10.1093/humrep/des463 · Cited by 747 · see citing works
Self-citation
The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global who guidance
Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., Stener-Victorin, E., Fauser, B. C. J. M., Norman, R. J., & Teede, H. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw025 · Cited by 705 · see citing works
Self-citation
The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
Lim, S. S., Norman, R. J., Davies, M. J., & Moran, L. J. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01053.x · Cited by 539 · see citing works
Treatment of obesity in polycystic ovary syndrome: A position statement of the Androgen Excess and Polycystic Ovary Syndrome Society
Moran, L. J., Pasquali, R., Teede, H. J., Hoeger, K. M., & Norman, R. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.018 · Cited by 444 · see citing works
Self-citation
Withdrawn: Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measurements at High Risk for Worsening Cardiovascular Event-Free Survival: Results from the National Institutes of Health—National Heart, Lung, and Blood Institute Sponsored Women’s Ischemia Syndrome Evaluation
Shaw, L. J., Bairey Merz, C. N., Azziz, R., Stanczyk, F. Z., Sopko, G., Braunstein, G. D., Kelsey, S. F., Kip, K. E., Cooper-DeHoff, R. M., Johnson, B. D., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0425 · Cited by 427 · see citing works
Retracted
Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline
Teede, H. J., Misso, M. L., Deeks, A. A., Moran, L. J., Stuckey, B. G. A., Wong, J. L. A., Norman, R. J., Costello, M. F., & Groups, O. B. O. T. G. D. (2011) · Medical Journal of Australia · doi:10.5694/mja11.10915 · Cited by 379 · see citing works
Self-citation
Metabolic features of the reproductive phenotypes of polycystic ovary syndrome
Moran, L., & Teede, H. (2009) · Human Reproduction Update · doi:10.1093/humupd/dmp008 · Cited by 362 · see citing works
Self-citation
Metabolic syndrome in polycystic ovary syndrome: a systematic review, meta‐analysis and meta‐regression
Lim, S. S., Kakoly, N. S., Tan, J. W. J., Fitzgerald, G., Bahri Khomami, M., Joham, A. E., Cooray, S. D., Misso, M. L., Norman, R. J., Harrison, C. L., et al. (2019) · Obesity Reviews · doi:10.1111/obr.12762 · Cited by 316 · see citing works
Self-citation
Lifestyle changes in women with polycystic ovary syndrome
Moran, L. J., Hutchison, S. K., Norman, R. J., & Teede, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub3 · Cited by 292 · see citing works
Self-citation
Exercise therapy in polycystic ovary syndrome: a systematic review
Harrison, C. L., Lombard, C. B., Moran, L. J., & Teede, H. J. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq045 · Cited by 267 · see citing works
Self-citation
The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials
Hoeger, K., Davidson, K., Kochman, L., Cherry, T., Kopin, L., & Guzick, D. S. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0461 · Cited by 256 · see citing works
Effects of Exercise on Insulin Resistance and Body Composition in Overweight and Obese Women with and without Polycystic Ovary Syndrome
Hutchison, S. K., Stepto, N. K., Harrison, C. L., Moran, L. J., Strauss, B. J., & Teede, H. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0828 · Cited by 192 · see citing works
Self-citation
Effects of Medical Therapy on Insulin Resistance and the Cardiovascular System in Polycystic Ovary Syndrome
Meyer, C., McGrath, B. P., & Teede, H. J. (2007) · Diabetes Care · doi:10.2337/dc06-0618 · Cited by 148 · see citing works
Self-citation
Women With Polycystic Ovary Syndrome Have an Increased Risk of Major Cardiovascular Events: a Population Study
Berni, T. R., Morgan, C. L., & Rees, D. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab392 · Cited by 146 · see citing works
Physical activity and mental health in women with Polycystic Ovary Syndrome
Banting, L. K., Gibson-Helm, M., Polman, R., Teede, H. J., & Stepto, N. K. (2014) · BMC Women's Health · doi:10.1186/1472-6874-14-51 · Cited by 121 · see citing works
Self-citation
Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta‐analysis of randomised trials
Pundir, J., Psaroudakis, D., Savnur, P., Bhide, P., Sabatini, L., Teede, H., Coomarasamy, A., & Thangaratinam, S. (2018) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14754 · Cited by 115 · see citing works
Self-citation
The impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome
Harrison, C. L., Stepto, N. K., Hutchison, S. K., & Teede, H. J. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04160.x · Cited by 80 · see citing works
Self-citation
Endothelial function and insulin resistance in polycystic ovary syndrome: The effects of medical therapy
Teede, H. J., Meyer, C., Hutchison, S. K., Zoungas, S., McGrath, B. P., & Moran, L. J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.034 · Cited by 68 · see citing works
Self-citation
A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome
Moran, L. J., Hutchison, S. K., Meyer, C., Zoungas, S., & Teede, H. J. (2009) · Clinical Science · doi:10.1042/cs20080218 · Cited by 59 · see citing works
Self-citation
The evaluation of endothelial function with flow-mediated dilatation and carotid intima media thickness in young nonobese polycystic ovary syndrom patients; existence of insulin resistance alone may not represent an adequate condition for deterioration of endothelial function
Arikan, S., Akay, H., Bahceci, M., Tuzcu, A., & Gokalp, D. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.11.057 · Cited by 49 · see citing works
Performance of mass spectrometry steroid profiling for diagnosis of polycystic ovary syndrome
Handelsman, D. J., Teede, H. J., Desai, R., Norman, R. J., & Moran, L. J. (2017) · Human Reproduction · doi:10.1093/humrep/dew328 · Cited by 47 · see citing works
Self-citation
The effects of 8 months of metformin on circulating GGT and ALT levels in obese women with polycystic ovarian syndrome: PCOS, NAFLD and metformin therapy
Preiss, D., Sattar, N., Harborne, L., Norman, J., & Fleming, R. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01825.x · Cited by 39 · see citing works
The effect of modifying dietary protein and carbohydrate in weight loss on arterial compliance and postprandial lipidemia in overweight women with polycystic ovary syndrome
Moran, L. J., Noakes, M., Clifton, P. M., & Norman, R. J. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.02.057 · Cited by 17 · see citing works
Oral contraceptives (OCs) in combination with metformin versus OCs alone on metabolism in nonobese polycystic ovary syndrome: a meta-analysis and systematic review of randomized controlled trials
Wu, L., Liu, Y., Huang, X., Lin, K., Liu, Y., Li, Z., Wei, T., Song, L., Hua, Y., & Wang, X. (2023) · Clinical Endocrinology · doi:10.1111/cen.14895 · Cited by 17 · see citing works

Subclinical Hypothyroidism
Nyström, E., Berg, G. E. B., Jansson, S. K. G., et al. (2010) · Springer eBooks · doi:10.1007/978-3-642-13262-9_13 · Cited by 3 · see citing works
Insulin resistance 'and polycystic ovary syndrome (PCOS) ': Part 1. The impact of insulin resistance
McEwen, B. J., & Hartmann, G. (2018) · Journal of the Australian Traditional-Medicine Society · Cited by 2 · see citing works
The relationship between epicardial fat thickness and insulin resistance in women with polycystic ovarian disease
Shahebrahimi, K., Rahimi, M., Salehi, N., et al. (2017) · Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Kirmānshāh · doi:10.22110/jkums.v21i1.2715
Insulin Resistance in Polycystic Ovary Syndrome Mechanism and Treatment Methods
Pei-pe, M. (2010) · Medical Recapitulate
The metabolic syndrome: Insulin resistance
Mikhail, N. E. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0027-4 · Cited by 80 · see citing works

Authors: Meyer, C., McGrath, B. P., & Teede, H. J.
Affiliations: Dandenong Hospital (AU)
Corresponding author: Teede, H. J.
ORCID: Teede, H. J.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2005-10
Volume: 90
Issue: 10
Pages: 5711-5716
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2005-0011
OpenAlex: W2113278318
Cited by: 273
References: 49
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 13 · 2014: 18 · 2013: 14 · 2012: 18
FWCI: 19.34
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: polycystic ovary syndrome, overweight women, subclinical cardiovascular disease, insulin resistance, arterial stiffness, endothelial dysfunction, carotid intima-media thickness, pulse wave velocity, flow-mediated dilation, cardiovascular risk factors, metabolic syndrome, androgens, dyslipidemia, cardiovascular risk stratification, cardiovascular mortality, cardiovascular disease prevention, cardiovascular screening
MeSH terms: Adult, Androgens, Australia, Blood Circulation, Blood Pressure, Brachial Artery, Cardiovascular Diseases, Carotid Arteries, Female, Hormones, Humans, Lipids, Menstruation, Obesity, Polycystic Ovary Syndrome, Risk Factors, Body Mass Index, Blood Pressure Monitoring, Ambulatory

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Overweight Women with Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks