The DOI matches its Crossref record; 313 of the 315 references it cites were found in a registry or an index.
Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing
Open accessAbstract
Objective To evaluate the possible role of endocrine-disrupting compounds (EDCs) on female reproductive disorders emphasizing developmental plasticity and the complexity of endocrine-dependent ontogeny of reproductive organs. Declining conception rates and the high incidence of female reproductive disruptions warrant evaluation of the impact of EDCs on female reproductive health.Design Publications related to the contribution of EDCs to disorders of the ovary (aneuploidy, polycystic ovary syndrome, and altered cyclicity), uterus (endometriosis, uterine fibroids, fetal growth restriction, and pregnancy loss), breast (breast cancer, reduced duration of lactation), and pubertal timing were identified, reviewed, and summarized at a workshop.Conclusion(s) The data reviewed illustrate that EDCs contribute to numerous human female reproductive disorders and emphasize the sensitivity of early life-stage exposures. Many research gaps are identified that limit full understanding of the contribution of EDCs to female reproductive problems. Moreover, there is an urgent need to reduce the incidence of these reproductive disorders, which can be addressed by correlative studies on early life exposure and adult reproductive dysfunction together with tools to assess the specific exposures and methods to block their effects. This review of the EDC literature as it relates to female health provides an important platform on which women's health can be improved.
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“Invariably, disruption of steroid hormone action was found to be causal, particularly during critical developmental windows (39–41).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [40]
Experimental — accuracy not yet measuredIn the citing paper
“Animal studies also show that endometriosis can be promoted by adult exposures to organochlorines, a class of chemicals that includes the dioxin, tetrachlorodibenzo-p-dioxin, the pesticides methoxychlor and dichlorodiphenyltrichloroethane, and polychlorinated biphenyls with dioxin-like effects.57”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [57]
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Citations
Cites
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Self-citationThe Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585
Self-citationHormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Self-citationPathogenesis and pathophysiology of endometriosis
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Self-citationState-of-the-science of endocrine disrupting chemicals, 2012
Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
Self-citationEndocrine disrupting chemicals and disease susceptibility
Schug, T. T., Janesick, A., Blumberg, B., & Heindel, J. J. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.08.007 · Cited by 1,145
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Metadata
- Authors
- Crain, D. A., Janssen, S. J., Edwards, T. M., Heindel, J., Ho, S.-M., Hunt, P., Iguchi, T., Juul, A., McLachlan, J. A., Schwartz, J., Skakkebaek, N., Soto, A. M., Swan, S., Walker, C., Woodruff, T. K., Woodruff, T. J., Giudice, L. C., & Guillette, L. J.
- Affiliations
- Maryville College (US)
- Natural Resources Defense Council (US)
- University of Florida (US)
- National Institute of Environmental Health Sciences (US)
- University of Cincinnati (US)
- Washington State University (US)
- National Institute for Basic Biology (JP)
- Rigshospitalet (DK)
- University of California, San Francisco (US)
- Tufts University (US)
- University of Rochester Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- Northwestern University (US)
- Corresponding author
- Guillette, Louis J.
- ORCID
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 90
- Issue
- 4
- Pages
- 911-940
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC4086418
- OpenAlex
- W2154968546
- Cited by
- 465
- References
- 315
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 17 · 2023: 28 · 2022: 31 · 2021: 31 · 2020: 20 · 2019: 28 · 2018: 19 · 2017: 20 · 2016: 38 · 2015: 31 · 2014: 29 · 2013: 35 · 2012: 25
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Institute of Environmental Health Sciences (P30ES006096)
- National Institute of Dental and Craniofacial Research (UL1DE019587)
- National Center for Research Resources (UL1RR024926)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD076188, U54HD041857)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- endocrine disruptors, female reproductive disorders, developmental plasticity, early life exposure, polycystic ovary syndrome, endometriosis, uterine fibroids, fetal growth restriction, miscarriage, breast cancer, lactation length, pubertal timing, reproductive disorders
- MeSH terms
- Female, Genital Diseases, Female, Humans, Pregnancy, Pregnancy Outcome, Reproduction, Endocrine Disruptors
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