The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic
Open accessAbstract
Objective To examine the association between body weight and measures of male reproductive potential. Design Cross-sectional study Setting Fertility clinic in an academic medical center. Patients 483 male partners of subfertile couples. Interventions None Main outcome measures Standard semen analysis, sperm DNA fragmentation and serum levels of reproductive hormones. Results As expected, BMI was positively related to estradiol levels and inversely related to total testosterone and SHBG levels. There was also a strong inverse relation between BMI and inhibin B levels and a lower testosterone:LH ratio among men with a BMI ≥ 35kg/m2. BMI was unrelated to sperm concentration, motility or morphology. Ejaculate volume decreased steadily with increasing BMI levels. Further, men with BMI ≥ 35kg/m2 had a lower total sperm count (concentration × volume) than normal weight men (Adjusted difference in the median [95% CI] = −86 × 106 sperm [−134, −37]). Sperm with high DNA damage were significantly more numerous in obese men than in normal weight men. Conclusions These data suggest that despite major differences in reproductive hormone levels with increasing body weight, only extreme levels of obesity may negatively influence male reproductive potential.
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Cites
Predictive value of abnormal sperm morphology in in vitro fertilization
Kruger, T. F., Acosta, A. A., Simmons, K. F., Swanson, R. J., Matta, J. F., & Oehninger, S. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59660-5 · Cited by 1,159
Wu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939
Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: A Randomized Controlled Trial
Esposito, K., Giugliano, F., Di Palo, C., Giugliano, G., Marfella, R., D'Andrea, F., D'Armiento, M., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.291.24.2978 · Cited by 841 · cited 1×
“Obese men are at increased risk of erectile dysfunction (22, 23).”
BackgroundObesity and androgens: facts and perspectives
Pasquali, R. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.054 · Cited by 469
Vermeulen, A. (1993) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.76.5.1140 · Cited by 346
Pathogenesis of the decreased androgen levels in obese men.
Giagulli, V. A., Kaufman, J. M., & Vermeulen, A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962311 · Cited by 215
Effect of Massive Weight Loss on Hypothalamic Pituitary-Gonadal Function in Obese Men*
STRAIN, G. W., ZUMOFF, B., MILLER, L. K., ROSNER, W., LEVIT, C., KALIN, M., HERSHCOPF, R. J., & ROSENFELD, R. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-5-1019 · Cited by 103
Trisini, A. T., Singh, N. P., Duty, S. M., & Hauser, R. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.05.087 · Cited by 83
Self-citation
Cited by
Fullston, T., Teague, E. M. C. O., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. (2013) · The FASEB Journal · doi:10.1096/fj.12-224048 · Cited by 600
Impact of obesity on male fertility, sperm function and molecular composition
Palmer, N. O., Bakos, H. W., Fullston, T., & Lane, M. (2012) · Spermatogenesis · doi:10.4161/spmg.21362 · Cited by 403
Campbell, J. M., Lane, M., Owens, J. A., & Bakos, H. W. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.07.012 · Cited by 332
Michalakis, K., Mintziori, G., Kaprara, A., Tarlatzis, B. C., & Goulis, D. G. (2013) · Metabolism · doi:10.1016/j.metabol.2012.08.012 · Cited by 321
Obesity: modern man's fertility nemesis
Cabler, S., Agarwal, A., Flint, M., & Du Plessis, S. S. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2010.38 · Cited by 184
Metadata
- Authors
- Chavarro, J. E., Toth, T. L., Wright, D. L., Meeker, J. D., & Hauser, R.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 93
- Issue
- 7
- Pages
- 2222-2231
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2058216443
- Cited by
- 573
- References
- 8
- FWCI
- 25.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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