Cited by 88Endometriosis Research and TreatmentGynecological conditions and treatmentsEndometrial and Cervical Cancer Treatments

Endometrium from women with endometriosis shows increased proliferation activity

Open access
Park, Jae Sun, Lee, Jae Hoon, Kim, Miran, Chang, Hye Jin, Hwang, Kyung Joo, Chang, Ki Hong·2009·Fertility and Sterility

Abstract

Examination of 631 infertile women, including 434 women with endometriosis and 197 without endometriosis, revealed an increasing incidence of endometrial polyps, especially in the test subjects with endometriosis, and advanced stages of endometriosis. Expression of Ki-67 and Bcl-2 proteins and MTT assay results were significantly higher in endometrium of patients with endometriosis than in patients without endometriosis. These showed increased proliferation activity and cell proliferation markers not only clinically but also pathologically.

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Crossref · 10.1016/j.fertnstert.2009.04.025

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  • Ki-67 is highly expressed in endometriosis.

    “Ki-67 is a nuclear protein involved in cellular proliferation and highly expressed in endometriosis.24”

    From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [24]

  • Increased proliferation, invasion, and resistance to apoptosis may potentially explain the pathogenesis of endometriosis; several of these characteristic behaviors have been previously linked to epigenetic alterations.

    “Increased proliferation, invasion, and resistance to apoptosis may potentially explain the pathogenesis of endometriosis; several of these characteristic behaviors of endometriosis have been previously linked to epigenetic alterations.23,24”

    From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [24]

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Research works printed but not linked: 1

  1. Christodoulakos G, Augoulea A, Lambrinoudaki I, Sioulas V, Creatsas G. Pathogenesis of endometriosis: the role of 'immunosur- veillance.' Eur J Contracept Reprod Health Care 2007;12:194-202.

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Authors
Park, J. S., Lee, J. H., Kim, M., Chang, H. J., Hwang, K. J., & Chang, K. H.
Affiliations
Ajou University (KR)
Corresponding author
Kim, Miran
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2009-10
Volume
92
Issue
4
Pages
1246-1249
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2147110454
Cited by
88
References
19
Citations by year
2026: 8 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 2
FWCI
4.71
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • AJOU Open Repository (Ajou University) (submittedVersion)
Funders
Ajou University
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
endometriosis, endometrial proliferation, endometrial polyps, infertility, Ki-67, Bcl-2, cell proliferation markers, endometrium, endometriosis stage
MeSH terms
Adult, Endometriosis, Endometrium, Female, Humans, Polyps, Uterine Diseases, Biomarkers, Case-Control Studies, Proto-Oncogene Proteins c-bcl-2, Ki-67 Antigen, Cell Proliferation

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