Cited by 286Endometriosis Research and TreatmentReproductive System and PregnancyReproductive Biology and Fertility

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

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Lessey, Bruce A., Kim, J. Julie·2017·Fertility and Sterility

Abstract

The endometrium maintains complex controls on proliferation and apoptosis as part of repetitive menstrual cycles that prepare the endometrium for the window of implantation and pregnancy. The reliance on inflammatory mechanisms for both implantation and menstruation creates the opportunity in the setting of endometriosis for establishment of chronic inflammation that is disruptive to endometrial receptivity, causing both infertility and abnormal bleeding. Clinically, there can be little doubt that the endometrium of women with endometriosis is less receptive to embryo implantation, and strong evidence exists to suggest that endometrial changes are associated with decreased cycle fecundity as a result of this disease. Here we provide unifying concepts regarding those changes and how they are coordinated to promote progesterone resistance and estrogen dominance through aberrant cell signaling pathways and reduced expression of key homeostatic proteins in eutopic endometrium of women with endometriosis.

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Crossref · 10.1016/j.fertnstert.2017.05.031

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167 of 167 references verified0 citation errors · 0 not checkable

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  • The endometrium shows several abnormalities in women with endometriosis, resulting in reduced endometrial receptivity and a lower embryo implantation rate.

    “The endometrium, according to multiple authors, shows several abnormalities in women with endometriosis, resulting in reduced endometrial receptivity and a lower embryo implantation rate (Lessey and Kim, 2017”
  • Endometrial chronic inflammation, together with progesterone resistance, estrogen dominance, aberrant cell signaling pathways and reduced expression of key homeostatic proteins in women with endometriosis, are disruptive to endometrial receptivity.

    “The endometrial chronic inflammation, together with progesterone resistance, estrogen dominance, aberrant cell signaling pathways and reduced expression of key homeostatic proteins in women with endometriosis, are disruptive to endometrial receptivity [158].”

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Cites

2 retracted

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Research works printed but not linked: 5

  1. [42]Lessey BA A Model for Implantation Based on Integrin Expression in the Human Endometrium 2nd World Conference on Implantation 1994 Abst
  2. [60]Ahn SH Khalaj K Young SL Lessey BA Koti M Tayade C Immune-inflammation gene signatures in endometriosis patients Fertility and sterility 2016 PMC5683404 27475412
  3. [105]Kao LC Germeyer A Tulac S Lobo S Yang JP Taylor RN Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility Endocrinology 2003 144 2870 81 12810542
  4. [136]Burney RO Talbi S Hamilton AE Vo KC Nyegaard M Nezhat CR Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis Endocrinology 2007 148 3814 26 17510236
  5. [147]Psychoyos A Mandon P Etude de la surface de l'epithelium uterin au microscope electronique a balayage CRHebdSeances AcadSciParis 1971 272 2723 5 4997225

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Authors
Lessey, B. A., & Kim, J. J.
Affiliations
  • Prisma Health (US)
  • Northwestern University (US)
Corresponding author
Lessey, Bruce A.
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2017-07
Volume
108
Issue
1
Pages
19-27
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2624413373
Cited by
286
References
167
Citations by year
2026: 29 · 2025: 26 · 2024: 33 · 2023: 41 · 2022: 41 · 2021: 38 · 2020: 42 · 2019: 20 · 2018: 11 · 2017: 4
FWCI
3.41
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD067721)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
endometriosis, endometrial receptivity, eutopic endometrium, embryo implantation, chronic inflammation, infertility, abnormal uterine bleeding, progesterone resistance, estrogen dominance, signaling pathways, menstrual cycle
MeSH terms
Animals, Embryo Transfer, Endometriosis, Endometrium, Female, Fertilization in Vitro, Humans, Infertility, Female, Menstrual Cycle, Embryo Implantation, Pregnancy, Recurrence, Species Specificity, Treatment Failure, Models, Immunological, Evidence-Based Medicine, Transcriptome

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