Apoptosis and endometriosis

Taniguchi, Fuminori

doi:10.2741/e277

Cited by 141Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementCell death mechanisms and regulation

Apoptosis and endometriosis

Taniguchi, Fuminori·2011·Frontiers in Bioscience

DOI 10.2741/e277

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Abstract

Apoptosis is a distinctive form of programmed cell death resulting in the efficient elimination of cells without eliciting an inflammatory response. Endometriosis is characterized by the presence of endometrial cells with capacity to avoid apoptosis outside the uterus. Apoptosis plays a fundamental role for the pathogenesis of endometriosis. Eutopic endometrium from women with endometriosis has increased expression of anti-apoptotic factor and decreased expression of pro-apoptotic factors compared with endometrium from healthy women. These differences could contribute to the survival of regurgitating endometrial cells into the peritoneal cavity and development of endometriosis. Increased apoptosis of Fas-bearing immune cells in the peritoneal cavity may leads to their decreased scavenger activity that eventually results in prolonged survival of ectopic endometrial cells in women with endometriosis. This study is a current review of the literatures focused on the physiological role of apoptosis in normal endometrium and alterations in regulation of apoptosis in eutopic and ectopic endometrium from women with endometriosis. The role of apoptosis in the treatment of endometriosis is also reviewed.

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In endometriosis, there is altered expression of BCL-2 in the eutopic endometrium and thereby fewer apoptotic cells and abnormal survival in ectopic sites.
“In endometriosis, there is altered expression of BCL-2 in the eutopic endometrium and thereby fewer apoptotic cells and abnormal survival in ectopic sites.109”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [109]
In the normal endometrium, BCL-2 inhibits apoptosis during the proliferative phase of the cycle.
“In the normal endometrium, BCL-2, acting as a cell death repressor, is reported to inhibit apoptosis during the proliferative phase of the cycle.”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [109]
Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.
“Women with endometriosis are reported to have reduced endometrial apoptosis with increased expression of antiapoptotic and decreased expression of proapoptotic factors.”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [109]
Decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis.
“It is thought that the decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis.109,110”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [109]

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Authors: Taniguchi, F.
Affiliations: Tottori University Hospital (JP)
Corresponding author: Taniguchi, Fuminori
ORCID: Taniguchi, Fuminori
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2011
Volume: E3
Issue: 2
Pages: 648-662
ISSN: 1944-7892 (ISSN-L)
1945-0494
1945-0508
DOI: 10.2741/e277
OpenAlex: W2027809130
Cited by: 141
References: 156
Citations by year: 2026: 3 · 2025: 7 · 2024: 10 · 2023: 9 · 2022: 8 · 2021: 12 · 2020: 5 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 10
FWCI: 11.00
Type: journal article
Language: en
Open access: closed
Locations: Frontiers in Bioscience-Elite (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: apoptosis, endometriosis, programmed cell death, eutopic endometrium, ectopic endometrial cells, anti-apoptotic factors, pro-apoptotic factors, peritoneal cavity, endometriosis pathogenesis, endometriosis treatment
MeSH terms: Endometriosis, Endometrium, Female, Humans, Mitochondria, Apoptosis, Macrophages, Peritoneal, Proto-Oncogene Proteins c-bcl-2, Fas Ligand Protein

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Apoptosis and endometriosis

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