Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis
Open accessAbstract
To test the hypothesis that bacterial contamination of menstrual blood could be a local biologic event in the development of endometriosis, menstrual blood was cultured and bacterial endotoxin was measured in menstrual blood and peritoneal fluid. Our results suggest that compared with control women, higher colony formation of Escherichia coli in menstrual blood and endotoxin levels in menstrual fluid and peritoneal fluid in women with endometriosis may promote Toll-like receptor 4-mediated growth of endometriosis.
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Endometriosis is associated with higher concentrations of Escherichia coli in menstrual blood, with vaginal infections, and with chronic endometritis.
“Endometriosis is associated with higher concentrations of Escherichia coli in menstrual blood (134, 135), with vaginal infections (136), and with chronic endometritis (137).”
From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [134]
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- Authors
- Khan, K. N., Kitajima, M., Hiraki, K., Yamaguchi, N., Katamine, S., Matsuyama, T., Nakashima, M., Fujishita, A., Ishimaru, T., & Masuzaki, H.
- Affiliations
- Nagasaki University (JP)
- Atomic Bomb Disease Institute, Nagasaki University (JP)
- Sasebo Chuo Hospital (JP)
- Corresponding author
- Khan, Khaleque Newaz
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 94
- Issue
- 7
- Pages
- 2860-2863.e3
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2039152389
- Cited by
- 195
- References
- 25
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 28 · 2023: 25 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 16 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 6 · 2012: 3
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (acceptedVersion)
- Nagasaki University's Academic Output SITE (Nagasaki University) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, Escherichia coli, bacterial contamination, menstrual blood, bacterial endotoxin, peritoneal fluid, TLR4
- MeSH terms
- Adolescent, Adult, Ascitic Fluid, Blood, Cells, Cultured, Endometriosis, Endotoxins, Escherichia coli Infections, Female, Humans, Menstruation, Peritoneal Diseases, Colony Count, Microbial, Case-Control Studies, Cytokines, Young Adult
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