Cited by 195Endometriosis Research and TreatmentMenstrual Health and DisordersGynecological conditions and treatments

Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis

Open access
Khan, Khaleque Newaz, Kitajima, Michio, Hiraki, Koichi, Yamaguchi, Naohiro, Katamine, Shigeru, Matsuyama, Toshifumi, Nakashima, Masahiro, Fujishita, Akira +2 more·2010·Fertility and Sterility

Abstract

To test the hypothesis that bacterial contamination of menstrual blood could be a local biologic event in the development of endometriosis, menstrual blood was cultured and bacterial endotoxin was measured in menstrual blood and peritoneal fluid. Our results suggest that compared with control women, higher colony formation of Escherichia coli in menstrual blood and endotoxin levels in menstrual fluid and peritoneal fluid in women with endometriosis may promote Toll-like receptor 4-mediated growth of endometriosis.

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Registry

Crossref · 10.1016/j.fertnstert.2010.04.053

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  • Endometriosis is associated with higher concentrations of Escherichia coli in menstrual blood, with vaginal infections, and with chronic endometritis.

    “Endometriosis is associated with higher concentrations of Escherichia coli in menstrual blood (134, 135), with vaginal infections (136), and with chronic endometritis (137).”

    From Pathogenesis of endometriosis: The genetic/epigenetic theory (2019) · cites this paper as [134]

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Authors
Khan, K. N., Kitajima, M., Hiraki, K., Yamaguchi, N., Katamine, S., Matsuyama, T., Nakashima, M., Fujishita, A., Ishimaru, T., & Masuzaki, H.
Affiliations
  • Nagasaki University (JP)
  • Atomic Bomb Disease Institute, Nagasaki University (JP)
  • Sasebo Chuo Hospital (JP)
Corresponding author
Khan, Khaleque Newaz
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2010-12
Volume
94
Issue
7
Pages
2860-2863.e3
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2039152389
Cited by
195
References
25
Citations by year
2026: 9 · 2025: 18 · 2024: 28 · 2023: 25 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 16 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 6 · 2012: 3
FWCI
4.93
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (acceptedVersion)
  • Nagasaki University's Academic Output SITE (Nagasaki University) (submittedVersion, cc-by-nc-nd)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, Escherichia coli, bacterial contamination, menstrual blood, bacterial endotoxin, peritoneal fluid, TLR4
MeSH terms
Adolescent, Adult, Ascitic Fluid, Blood, Cells, Cultured, Endometriosis, Endotoxins, Escherichia coli Infections, Female, Humans, Menstruation, Peritoneal Diseases, Colony Count, Microbial, Case-Control Studies, Cytokines, Young Adult

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