The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis
Open accessAbstract
Objective To evaluate the effects of celecoxib and rosiglitazone on the implantation and growth of endometriotic-like lesions in a murine model of endometriosis.Design Prospective experimental study.Setting Animal research and laboratory facility.Animal(s) Two-month-old female BALB/c mice.Intervention(s) Surgically induced endometriosis in female BALB/C mice; 28 days of treatment with celecoxib, rosiglitazone, or their combination; counting, measuring, excising, and fixing lesions.Main outcome measure(s) Immunohistochemical examination for proliferating cell nuclear antigen (PCNA), CD31, and CD34 to assess cell proliferation and vascularization, with the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technique for apoptosis evaluation.Result(s) Celecoxib and the combined treatment (celecoxib and rosiglitazone) statistically significantly reduced the mean number of lesions established per mouse, and all treatments diminished the implant volume. In addition, cell proliferation within the implants was statistically significantly reduced, and apoptosis was statistically significantly enhanced by all treatments. Also, we found that all treatments diminished the vascularized area in the lesion.Conclusion(s) These results are promising and reveal that celecoxib and rosiglitazone, combined or separately, have a beneficial effect on overall endometriotic growth.
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Experimental data suggest that anti-inflammatory drugs may affect the severity of endometriosis.
“Moreover, experimental data suggest that anti-inflammatory drugs may affect the severity of the disease (61, 62).”
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- Authors
- Olivares, C., Ricci, A., Bilotas, M., Barañao, R. I., & Meresman, G.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Olivares, Carla
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 96
- Issue
- 2
- Pages
- 428-433
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2111680823
- Cited by
- 65
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 7
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Agencia Nacional de Promoción Científica y Tecnológica (PICT 6384 BID 1201 OC-AR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (PIP 5471)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- endometriosis, celecoxib, rosiglitazone, COX-2 inhibitors, thiazolidinediones, endometriotic lesion growth, cell proliferation, apoptosis, angiogenesis, vascularization, combination therapy
- MeSH terms
- Celecoxib, Rosiglitazone, Analysis of Variance, Animals, Disease Models, Animal, Drug Therapy, Combination, Endometriosis, Female, Immunohistochemistry, Mice, Inbred BALB C, Neovascularization, Pathologic, Pyrazoles, Sulfonamides, Time Factors, Uterus, Apoptosis, Proliferating Cell Nuclear Antigen, Antigens, CD34, Platelet Endothelial Cell Adhesion Molecule-1, In Situ Nick-End Labeling, Thiazolidinediones, PPAR gamma, Cell Proliferation, Mice, Cyclooxygenase 2 Inhibitors
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