Cited by 65Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementInflammatory mediators and NSAID effects

The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis

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Olivares, Carla, Ricci, Analía, Bilotas, Mariela, Barañao, Rosa Inés, Meresman, Gabriela·2011·Fertility and Sterility

Abstract

Objective To evaluate the effects of celecoxib and rosiglitazone on the implantation and growth of endometriotic-like lesions in a murine model of endometriosis.Design Prospective experimental study.Setting Animal research and laboratory facility.Animal(s) Two-month-old female BALB/c mice.Intervention(s) Surgically induced endometriosis in female BALB/C mice; 28 days of treatment with celecoxib, rosiglitazone, or their combination; counting, measuring, excising, and fixing lesions.Main outcome measure(s) Immunohistochemical examination for proliferating cell nuclear antigen (PCNA), CD31, and CD34 to assess cell proliferation and vascularization, with the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technique for apoptosis evaluation.Result(s) Celecoxib and the combined treatment (celecoxib and rosiglitazone) statistically significantly reduced the mean number of lesions established per mouse, and all treatments diminished the implant volume. In addition, cell proliferation within the implants was statistically significantly reduced, and apoptosis was statistically significantly enhanced by all treatments. Also, we found that all treatments diminished the vascularized area in the lesion.Conclusion(s) These results are promising and reveal that celecoxib and rosiglitazone, combined or separately, have a beneficial effect on overall endometriotic growth.

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Crossref · 10.1016/j.fertnstert.2011.05.063

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  1. Valle RF, Sciarra JJ. Endometriosis: treatment strate- gies. Ann NY Acad Sci 2003;997:229-39.
  2. Wu MH, Lu CW, Chuang PC, Tsai SJ. Prostaglandin E2: the master of endometriosis? Exp Biol Med (Maywood) 2010;235:668-77.
  3. Mihalyi A, Simsa P, Mutinda KC, Meuleman C, Mwenda JM, D'Hooghe TM. Emerging drugs in endo- metriosis. Expert Opin Emerg Drugs 2006;11:503-24.
  4. Elder DJ, Halton DE, Crew TE, Paraskeva C. Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflam- matory drug NS-398. Int J Cancer 2000;86:553-60.

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Authors
Olivares, C., Ricci, A., Bilotas, M., Barañao, R. I., & Meresman, G.
Affiliations
Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
Corresponding author
Olivares, Carla
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2011-08
Volume
96
Issue
2
Pages
428-433
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2111680823
Cited by
65
References
54
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 7
FWCI
7.89
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Funders
  • Agencia Nacional de Promoción Científica y Tecnológica (PICT 6384 BID 1201 OC-AR)
  • Consejo Nacional de Investigaciones Científicas y Técnicas (PIP 5471)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
endometriosis, celecoxib, rosiglitazone, COX-2 inhibitors, thiazolidinediones, endometriotic lesion growth, cell proliferation, apoptosis, angiogenesis, vascularization, combination therapy
MeSH terms
Celecoxib, Rosiglitazone, Analysis of Variance, Animals, Disease Models, Animal, Drug Therapy, Combination, Endometriosis, Female, Immunohistochemistry, Mice, Inbred BALB C, Neovascularization, Pathologic, Pyrazoles, Sulfonamides, Time Factors, Uterus, Apoptosis, Proliferating Cell Nuclear Antigen, Antigens, CD34, Platelet Endothelial Cell Adhesion Molecule-1, In Situ Nick-End Labeling, Thiazolidinediones, PPAR gamma, Cell Proliferation, Mice, Cyclooxygenase 2 Inhibitors

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