CoChat
Sign Up
Cited by 344Endometriosis Research and TreatmentUterine Myomas and TreatmentsGynecological conditions and treatments

The DOI matches its Crossref record; 98 of the 100 references it cites were found in a registry or an index.

Pathogenesis of uterine adenomyosis, invagination or metaplasia?

Open access
García-Solares, Javier, Donnez, Jacques, Donnez, Olivier, Dolmans, Marie-Madeleine·2018·Fertility and Sterility
DOI 10.1016/j.fertnstert.2017.12.030
Open this paper in CoChat — free account

Abstract

Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that causes pelvic pain, abnormal uterine bleeding, and infertility. Despite its prevalence and severity of symptoms, its pathogenesis and etiology have not yet been elucidated. The aim of this manuscript is to review the different hypotheses on the origin of adenomyotic lesions and the mechanisms involved in the evolution and progression of the disease. Two main theories have been proposed to explain the origin of adenomyosis. The most common suggests involvement of tissue injury and the repair mechanism and claims that adenomyosis results from invagination of the endometrial basalis into the myometrium. An alternative theory maintains that adenomyotic lesions result from metaplasia of displaced embryonic pluripotent Müllerian remnants or differentiation of adult stem cells. Previous investigations performed in human adenomyotic lesions and corroborated by studies in mice supported the involvement of the epithelial-mesenchymal transition process in the early stages of progression and spread of adenomyosis. However, studies conducted in a recently developed baboon model indicate that collective cell migration may be implicated in the later events of invasion. This suggests that the invasiveness of this complex uterine disorder is not driven by a single mechanism of migration but by a time-dependent combination of two processes.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2017.12.030

Cites

98 of 98 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 100 references

Research works printed but not linked: 1

  1. Siegler, 1994, Adenomyosis, J Reprod Med, 39, 841

Cited by

Sorted by citations

Items 301–344 of 344

Related

See all

Metadata

Authors
García-Solares, J., Donnez, J., Donnez, O., & Dolmans, M.-M.
Affiliations
  • UCLouvain (BE)
  • Cliniques Universitaires Saint-Luc (BE)
Corresponding author
Dolmans, Marie-Madeleine
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2018-03
Volume
109
Issue
3
Pages
371-379
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/j.fertnstert.2017.12.030
OpenAlex
W2794246050
Cited by
339
References
100
Citations by year
2026: 39 · 2025: 46 · 2024: 33 · 2023: 48 · 2022: 57 · 2021: 53 · 2020: 41 · 2019: 17 · 2018: 4
FWCI
4.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
adenomyosis, pathogenesis, metaplasia, Müllerian remnants, stem cell differentiation, epithelial-mesenchymal transition, collective cell migration, baboon model, myometrium, estrogen-dependent disease
MeSH terms
Animals, Cell Movement, Estradiol, Female, Humans, Metaplasia, Mullerian Ducts, Time Factors, Uterine Diseases, Uterus, Signal Transduction, Disease Progression, Pluripotent Stem Cells, Epigenesis, Genetic, Embryonic Stem Cells, Adult Stem Cells, Epithelial-Mesenchymal Transition, Adenomyosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review