Cited by 344Endometriosis Research and TreatmentUterine Myomas and TreatmentsGynecological conditions and treatments

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Pathogenesis of uterine adenomyosis, invagination or metaplasia?

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García-Solares, Javier, Donnez, Jacques, Donnez, Olivier, Dolmans, Marie-Madeleine·2018·Fertility and Sterility

DOI 10.1016/j.fertnstert.2017.12.030

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Abstract

Adenomyosis is a commonly diagnosed estrogen-dependent gynecological disorder that causes pelvic pain, abnormal uterine bleeding, and infertility. Despite its prevalence and severity of symptoms, its pathogenesis and etiology have not yet been elucidated. The aim of this manuscript is to review the different hypotheses on the origin of adenomyotic lesions and the mechanisms involved in the evolution and progression of the disease. Two main theories have been proposed to explain the origin of adenomyosis. The most common suggests involvement of tissue injury and the repair mechanism and claims that adenomyosis results from invagination of the endometrial basalis into the myometrium. An alternative theory maintains that adenomyotic lesions result from metaplasia of displaced embryonic pluripotent Müllerian remnants or differentiation of adult stem cells. Previous investigations performed in human adenomyotic lesions and corroborated by studies in mice supported the involvement of the epithelial-mesenchymal transition process in the early stages of progression and spread of adenomyosis. However, studies conducted in a recently developed baboon model indicate that collective cell migration may be implicated in the later events of invasion. This suggests that the invasiveness of this complex uterine disorder is not driven by a single mechanism of migration but by a time-dependent combination of two processes.

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302
Collective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,804
Linking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267
The snail superfamily of zinc-finger transcription factors
Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.
Acloque, H., Adams, M. S., Fishwick, K., Bronner-Fraser, M., & Nieto, M. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38019 · Cited by 1,350
Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities
Nisolle, M., & Donnez, J. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00191-x · Cited by 1,279
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
Bolós, V., Peinado, H., Pérez‐Moreno, M., Fraga, M. F., Esteller, M., & Cano, A. (2002) · Journal of Cell Science · doi:10.1242/jcs.00224 · Cited by 1,100
Classifying collective cancer cell invasion
Friedl, P., Locker, J. D., Sahai, E. A., & Segall, J. E. (2012) · Nature Cell Biology · doi:10.1038/ncb2548 · Cited by 966
Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group
den Bosch, T. V., Dueholm, M., Leone, F. P., Valentin, L., Rasmussen, C. K., Votino, A., Schoubroeck, D. V., Landolfo, C., Installé, A., Guerriero, S., et al. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14806 · Cited by 776
Epithelial–mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic
Voulgari, A., & Pintzas, A. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.03.002 · Cited by 683
Clonogenicity of Human Endometrial Epithelial and Stromal Cells1
Chan, R. W. S., Schwab, K. E., & Gargett, C. E. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.024109 · Cited by 653
Cadherin Switch in Tumor Progression
Hazan, R. B., QIAO, R., Keren, R., Badano, I., & Suyama, K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1294.016 · Cited by 595
Endometrial stem/progenitor cells: the first 10 years
Gargett, C. E., Schwab, K. E., & Deane, J. A. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv051 · Cited by 561
The elusive adenomyosis of the uterus—revisited
Bird, C. C., McElin, T. W., & Manalo-Estrella, P. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90781-8 · Cited by 531
Pathophysiology of adenomyosis
Ferenczy, A. S. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.4.312 · Cited by 512
The pathophysiology of endometriosis and adenomyosis, tissue injury and repair
Leyendecker, G., Wildt, L., & Mall, G. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1191-0 · Cited by 418
Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis
Vercellini, P., Consonni, D., Dridi, D., Bracco, B., Frattaruolo, M. P., & Somigliana, E. (2014) · Human Reproduction · doi:10.1093/humrep/deu041 · Cited by 411
Adenomyosis in endometriosis—Prevalence and impact on fertility. Evidence from magnetic resonance imaging
Kunz, G., Beil, D., Huppert, P., Noe, M., Kissler, S., & Leyendecker, G. (2005) · Human Reproduction · doi:10.1093/humrep/dei021 · Cited by 377
Uterine stem cells: What is the evidence?
Gargett, C. E. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml045 · Cited by 373
Pathology and physiopathology of adenomyosis
Bergeron, C., Amant, F., & Ferenczy, A. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.01.016 · Cited by 359
Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis
Bazot, M., & Daraï, É. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.024 · Cited by 332
Epigenetics of endometriosis
Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328
Pathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326
Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1
Kitawaki, J., Noguchi, T., Amatsu, T., Maeda, K., Tsukamoto, K., Yamamoto, T., Fushiki, S., Osawa, Y., & Honjo, H. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.3.514 · Cited by 305
Four subtypes of adenomyosis assessed by magnetic resonance imaging and their specification
Kishi, Y., Suginami, H., 蔵盛, 理., Yabuta, M., Suginami, R., & Taniguchi, F. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.06.027 · Cited by 301
Endometriosis results from the dislocation of basal endometrium
Leyendecker, G. (2002) · Human Reproduction · doi:10.1093/humrep/17.10.2725 · Cited by 300
Relationship between the magnetic resonance imaging appearance of adenomyosis and endometriosis phenotypes
Chapron, C., Tosti, C., Marcellin, L., Bourdon, M., Lafay-Pillet, M.-C., Millischer, A.-E., Streuli, I., Borghese, B., Petraglia, F., & Santulli, P. (2017) · Human Reproduction · doi:10.1093/humrep/dex088 · Cited by 294
Adenomyosis in endometriosis – prevalence and impact on fertility. Evidence from magnetic resonance imaging
Bazot, M., Fiori, O., & Daraï, É. (2006) · Human Reproduction · doi:10.1093/humrep/dei448 · Cited by 283
Adenomyosis and endometriosis. Re-visiting their association and further insights into the mechanisms of auto-traumatisation. An MRI study
Leyendecker, G., Bilgicyildirim, A., Inacker, M., Stalf, T., Huppert, P., Mall, G., Böttcher, B., & Wildt, L. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-014-3437-8 · Cited by 261
Oestrogen‐induced epithelial–mesenchymal transition of endometrial epithelial cells contributes to the development of adenomyosis
Chen, Y., Li, H., Huang, C., Twu, N.-F., Yen, M., Wang, P., Chou, T., Liu, Y., Chao, K.-C., & Yang, M. (2010) · The Journal of Pathology · doi:10.1002/path.2761 · Cited by 250
Putative stem cell activity of human endometrial epithelial and stromal cells during the menstrual cycle
Schwab, K. E., Chan, R. W. S., & Gargett, C. E. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.02.056 · Cited by 249
Structural and molecular features of the endomyometrium in endometriosis and adenomyosis
Benagiano, G., Brosens, I., & Habiba, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt052 · Cited by 246
Symptoms and classification of uterine adenomyosis, including the place of hysteroscopy in diagnosis
Gordts, S., Grimbizis, G., & Campo, R. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.006 · Cited by 246
Pathogenesis of deep endometriosis
Gordts, S., Koninckx, P., & Brosens, I. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.08.036 · Cited by 241
Risk factors for adenomyosis
Parazzini, F., Vercellini, P., Panazza, S., Chatenoud, L., Oldani, S., & Crosignani, P. G. (1997) · Human Reproduction · doi:10.1093/humrep/12.6.1275 · Cited by 213
Uterine adenomyosis in the infertility clinic
Devlieger, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg010 · Cited by 206
Increased expression of the adult stem cell marker Musashi‐1 in endometriosis and endometrial carcinoma
Götte, M., Wolf, M., Staebler, A., Buchweitz, O., Kelsch, R., Schüring, A. N., & Kiesel, L. (2008) · The Journal of Pathology · doi:10.1002/path.2364 · Cited by 195
Corroborating evidence for platelet-induced epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis
Liu, X., Shen, M., Qi, Q., Zhang, H., & Guo, S.-W. (2016) · Human Reproduction · doi:10.1093/humrep/dew018 · Cited by 190
Comparative Developmental Biology of the Mammalian Uterus
Spencer, T. E., Hayashi, K., Hu, J., & Carpenter, K. D. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)68004-0 · Cited by 179
Surgery: Rectovaginal septum, endometriosis or adenomyosis: Laparoscopic management in a series of 231 patients
Donnez, J., Nisolle, M., Casanas-Roux, F., Bassil, S., & Anaf, V. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136001 · Cited by 175
Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis
Mehasseb, M. K., Panchal, R., Taylor, A. H., Brown, L., Bell, S. C., & Habiba, M. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.02.051 · Cited by 165
Recto vaginal septum adenomyotic nodules: a series of 500 cases
Donnez, J., Nisolle, M., Gillerot, S., Smets, M., Bassil, S., & Casanas‐Roux, F. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb12059.x · Cited by 150
Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis
Huang, P., Tsai, E., Li, W.-F., Liao, P., Chung, M., Wang, Y.-H., & Wang, S. (2010) · Human Reproduction · doi:10.1093/humrep/deq015 · Cited by 148
A new concept of endometriosis and adenomyosis, tissue injury and repair (TIAR)
Leyendecker, G., & Wildt, L. (2011) · hmbci · doi:10.1515/hmbci.2011.002 · Cited by 147
Adenomyosis and endometriosis in the California Teachers Study
Templeman, C. E., Marshall, S. F., Ursin, G., Horn‐Ross, P. L., Clarke, C. A., Allen, M. S., Deapen, D., Ziogas, A., Reynolds, P., Cress, R. D., et al. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.027 · Cited by 140
Preoperative and Postoperative Clinical and Transvaginal Ultrasound Findings of Adenomyosis in Patients with Deep Infiltrating Endometriosis
Lazzeri, L., Di Giovanni, A., Exacoustos, C., Tosti, C., Pinzauti, S., Malzoni, M., Petraglia, F., & Zupi, E. (2014) · Reproductive Sciences · doi:10.1177/1933719114522520 · Cited by 137
The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis
Hufnagel, D. H., Li, F., Çoşar, E., Krikun, G., & Taylor, H. S. (2015) · Seminars in Reproductive Medicine · doi:10.1055/s-0035-1564609 · Cited by 134
Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis
Guo, S.-W., Mao, X., Ma, Q., & Liu, X. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.038 · Cited by 131
Is adenomyosis associated with menorrhagia?
Naftalin, J., Hoo, W., Pateman, K., Mavrelos, D., Foo, X., & Jurkovic, D. (2014) · Human Reproduction · doi:10.1093/humrep/det451 · Cited by 124
Transforming growth factor β1 signaling coincides with epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice
Shen, M., Liu, X., Zhang, H., & Guo, S.-W. (2015) · Human Reproduction · doi:10.1093/humrep/dev314 · Cited by 124
Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: Results from a prospective multicentric study in Italy
Parazzini, F., Mais, V., Cipriani, S., Busacca, M., & Venturini, P. L. (2009) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2008.12.010 · Cited by 123
Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Adenomyosis and Its Rectification by a Histone Deacetylase Inhibitor and a Demethylation Agent
Nie, J., Liu, X., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110377118 · Cited by 120
Persistence of dysmenorrhea and nonmenstrual pain after optimal endometriosis surgery may indicate adenomyosis
Parker, J. D., Leondires, M., Sinaii, N., Premkumar, A., Nieman, L. K., & Stratton, P. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.01.030 · Cited by 98
The important roles of steroid sulfatase and sulfotransferases in gynecological diseases
Rižner, T. L. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00030 · Cited by 98
Matrix Metalloproteinase-2 and -9 Expression Correlated with Angiogenesis in Human Adenomyosis
Tian, L., Li, Y., & Pu, D. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000094426 · Cited by 94
Understanding adenomyosis: a case control study
Taran, F., Weaver, A. L., Coddington, C. C., & Stewart, E. A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.06.049 · Cited by 92
A pilot study on the off-label use of valproic acid to treat adenomyosis
Liu, X., & Guo, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.009 · Cited by 87
Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide
Li, B., Chen, M., Liu, X., & Guo, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.04.028 · Cited by 78
An update on the pharmacological management of adenomyosis
Streuli, I., Dubuisson, J. B., Santulli, P., de Ziegler, D., Batteux, F., & Chapron, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.953055 · Cited by 75
Progesterone Induction of 17 -Hydroxysteroid Dehydrogenase Type 2 during the Secretory Phase Occurs in the Endometrium of Estrogen-Dependent Benign Diseases But Not in Normal Endometrium
Kitawaki, J., Koshiba, H., Ishihara, H., Kusuki, I., Tsukamoto, K., & Honjo, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6829 · Cited by 69
Valproic Acid as a Therapy for Adenomyosis: A Comparative Case Series
Liu, X., Yuan, L., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110373807 · Cited by 67
Stereometric evaluation of peritoneal endometriosis and endometriotic nodules of the rectovaginal septum
Donnez, J., Nisolle, M., Casanas-Roux, F., Brion, P., & DaFerreira, N. C. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019024 · Cited by 65
The Retardation of Myometrial Infiltration, Reduction of Uterine Contractility, and Alleviation of Generalized Hyperalgesia in Mice With Induced Adenomyosis by Levo-Tetrahydropalmatine (l-THP) and Andrographolide
Mao, X., Wang, Y., Carter, A. V., Zhen, X., & Guo, S. (2011) · Reproductive Sciences · doi:10.1177/1933719111404610 · Cited by 63
Effects of tamoxifen on the human female genital tract: review of the literature.
Varras, M., Polyzos, D., & Akrivis, C. (2003) · PubMed · Cited by 62
Clinical characteristics indicating adenomyosis at the time of hysterectomy: a retrospective study in 291 patients
Taran, F., Wallwiener, M., Kabashi, D., Rothmund, R., Rall, K., Kraemer, B., & Brucker, S. Y. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-011-2180-7 · Cited by 61
Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence
Zhu, B., Chen, Y., Shen, X., Liu, X., & Guo, S. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0198-1 · Cited by 61
Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes
Huang, P., Li, W. F., Liao, P.-C., Sun, C. W., Tsai, E., & Wang, S. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3260-6 · Cited by 59
High Frequency of Adenomyosis in Postmenopausal Breast Cancer Patients Treated with Tamoxifen
Cohen, I., Beyth, Y., Shapira, J., Tepper, R., Fishman, A., Cordoba, M., Bernheim, J., Yigael, D., & Altaras, M. M. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000291520 · Cited by 59
Differential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells
Flamini, M. I., Sanchez, A. M., Goglia, L., Tosi, V., Genazzani, A. R., & Simoncini, T. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap045 · Cited by 59
Molecular Characteristics of the Endometrium in Uterine Adenomyosis and Its Biochemical Microenvironment
Yen, C., Huang, S.-T. J., Lee, C., Wang, H., & Liao, S. (2017) · Reproductive Sciences · doi:10.1177/1933719117691141 · Cited by 57
Adenomyosis in a patient with the Rokitansky-Kuster-Hauser syndrome
Enatsu, A., Harada, T., Yoshida, S., Iwabe, T., & Terakawa, N. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00643-3 · Cited by 53
Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis
Qi, S., Ζhao, X., Li, M., Zhang, X., Lu, Z., Yang, C., Zhang, C., Zhang, H., & Zhang, N. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0084-2 · Cited by 52
Ultramicro-trauma in the endometrial-myometrial junctional zone and pale cell migration in adenomyosis
Ibrahim, M. G., Chiàntera, V., Frangini, S., Younes, S., Köhler, C., TAUBE, E. T., Plendl, J., & Mechsner, S. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.09.002 · Cited by 52
Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis
Liu, X., & Guo, S. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01655.x · Cited by 52
Myofibroblasts are evidence of chronic tissue microtrauma at the endometrial-myometrial junctional zone in uteri with adenomyosis
Ibrahim, M. G., Sillem, M., Plendl, J., Chiantera, V., Sehouli, J., & Mechsner, S. (2017) · Reproductive Sciences · doi:10.1177/1933719116687855 · Cited by 52
Invasion process of induced deep nodular endometriosis in an experimental baboon model: similarities with collective cell migration?
Donnez, O., Orellana, R., Kerk, O. V., Dehoux, J., Donnez, J., & Dolmans, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.05.011 · Cited by 51
Tamoxifen‐associated postmenopausal adenomyosis exhibits stromal fibrosis, glandular dilatation and epithelial metaplasias
McCluggage, W. G., Desai, V., & Manek, S. (2000) · Histopathology · doi:10.1046/j.1365-2559.2000.01001.x · Cited by 50
Zonal Changes in Proliferation in the Rhesus Endometrium During the Late Secretory Phase and Menses
Okulicz, W. C., Ace, C. I., & Scarrell, R. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-214-44079 · Cited by 49
Fetal hormones and sexual differentiation
Sobel, V., Zhu, Y.-S., & Imperato-McGinley, J. (2004) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2004.08.005 · Cited by 44
Important role of collective cell migration and nerve fiber density in the development of deep nodular endometriosis
Orellana, R., García-Solares, J., Donnez, J., Kerk, O. V., Dolmans, M., & Donnez, O. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.005 · Cited by 44
Induction of endometriotic nodules in an experimental baboon model mimicking human deep nodular lesions
Donnez, O., Van Langendonckt, A., Defrère, S., Colette, S., Van Kerk, O., Dehoux, J.-P., Squifflet, J., & Donnez, J. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.10.032 · Cited by 42
Self-citation
Uterine peristalsis-induced stresses within the uterine wall may sprout adenomyosis
Shaked, S., Jaffa, A. J., Grisaru, D., & Elad, D. (2014) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-014-0614-4 · Cited by 41
Aberrant Immunoreactivity of Deoxyribonucleic Acid Methyltransferases in Adenomyosis
Liu, X., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000337718 · Cited by 41
Elevated Immunoreactivity against Class I Histone Deacetylases in Adenomyosis
Liu, X., Nie, J., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000336409 · Cited by 41
Vascular Involvement in Adenomyosis: Report of a Large Series of a Common Phenomenon With Observations on the Pathogenesis of Adenomyosis
Meenakshi, M., & McCluggage, W. G. (2010) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e3181b7018d · Cited by 39
Stem cells in human normal endometrium and endometrial cancer cells: Characterization of side population cells
Kato, K. (2012) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2011.06.028 · Cited by 34
Cesarean section as a risk factor for the development of adenomyosis uteri.
Riggs, J. C., Lim, E. K., Liang, D., & Bullwinkel, R. (2014) · PubMed · Cited by 31
Increased matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 secretion but unaffected invasiveness of endometrial stromal cells in adenomyosis
Yang, J., Wu, M., Chen, M., Chen, S., Yang, Y., & Ho, H. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.05.090 · Cited by 30
COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis
Tong, X., Li, Z., Yao, W., Fu, X., Zhang, Y., & Fan, H. S. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.04.039 · Cited by 29
Genetic variation in COX-2 -1195 and the risk of endometriosis and adenomyosis
Wang, Y., Qu, Y., & Song, W. M. (2015) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog1747.2015 · Cited by 27
Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis
Ye, H., He, Y., Wang, J., Song, T., Zhu, L., Zhao, Y., & Xi, M. (2016) · Journal of Genetics · doi:10.1007/s12041-016-0675-5 · Cited by 27
Polymorphisms in the matrix metalloproteinase‐2 and tissue inhibitor of metalloproteinase‐2 and the risk of human adenomyosis
Kang, S., Zhao, X., Xing, H., Wang, N., Zhou, R., Chen, S., Li, W., Zhao, J., Duan, Y., Sun, D.-L., et al. (2008) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20375 · Cited by 26
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Abnormal expression of Nrf2 may play an important role in the pathogenesis and development of adenomyosis
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A pilot study on the use of andrographolide to treat symptomatic adenomyosis
Liu, X., Yu, S., & Guo, S. (2014) · Gynecology and Minimally Invasive Therapy · doi:10.1016/j.gmit.2014.12.002 · Cited by 16
Approaches to adenomyomectomy
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Expression of focal adhesion kinase in the eutopic endometrium of women with adenomyosis varies with dysmenorrhea and pelvic pain
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Research works printed but not linked: 1

Siegler, 1994, Adenomyosis, J Reprod Med, 39, 841

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See all 344

Authors: García-Solares, J., Donnez, J., Donnez, O., & Dolmans, M.-M.
Affiliations: UCLouvain (BE)
Cliniques Universitaires Saint-Luc (BE)
Corresponding author: Dolmans, Marie-Madeleine
ORCID: Donnez, Jacques
Donnez, Olivier
Dolmans, Marie-Madeleine
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2018-03
Volume: 109
Issue: 3
Pages: 371-379
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2017.12.030
OpenAlex: W2794246050
Cited by: 339
References: 100
Citations by year: 2026: 39 · 2025: 46 · 2024: 33 · 2023: 48 · 2022: 57 · 2021: 53 · 2020: 41 · 2019: 17 · 2018: 4
FWCI: 4.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1548 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: adenomyosis, pathogenesis, metaplasia, Müllerian remnants, stem cell differentiation, epithelial-mesenchymal transition, collective cell migration, baboon model, myometrium, estrogen-dependent disease
MeSH terms: Animals, Cell Movement, Estradiol, Female, Humans, Metaplasia, Mullerian Ducts, Time Factors, Uterine Diseases, Uterus, Signal Transduction, Disease Progression, Pluripotent Stem Cells, Epigenesis, Genetic, Embryonic Stem Cells, Adult Stem Cells, Epithelial-Mesenchymal Transition, Adenomyosis

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Pathogenesis of uterine adenomyosis, invagination or metaplasia?

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