The DOI matches its Crossref record; 101 of the 103 references it cites were found in a registry or an index.
Role of medical therapy in the management of uterine adenomyosis
Open accessAbstract
Adenomyosis is a benign uterine condition affecting women at various ages with different symptoms. The management of these patients is still controversial. Few clinical studies focusing on medical or surgical treatment for adenomyosis have been performed. No drug is currently labelled for adenomyosis and there are no specific guidelines to follow for the best management. Anyhow, medical treatments are effective in improving symptoms (pain, abnormal uterine bleeding and infertility). The rationale for using medical treatment is based on the pathogenetic mechanisms of adenomyosis: sex steroid hormones aberrations, impaired apoptosis, and increased inflammation. Several nonhormonal (i.e., nonsteroidal anti-inflammatory drugs) and hormonal treatments (i.e., progestins, oral contraceptives, gonadotropin-releasing hormone analogues) are currently used off-label to control pain symptoms and abnormal uterine bleeding in adenomyosis. Gonadotropin-releasing hormone analogues are indicated before fertility treatments to improve the chances of pregnancy in infertile women with adenomyosis. An antiproliferative and anti-inflammatory effect of progestins, such as dienogest, danazol and norethindrone acetate, suggests their use in medical management of adenomyosis mainly to control pain symptoms. On the other hand, the intrauterine device releasing levonorgestrel resulted is extremely effective in resolving abnormal uterine bleeding and reducing uterine volume in a long-term management plan. Based on new findings on pathogenetic mechanisms, new drugs are under development for the treatment of adenomyosis, such as selective progesterone receptor modulators, aromatase inhibitors, valproic acid, and anti-platelets therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The clinical treatment strategy for the two diseases also seems to be similar, and the drugs to treat the two diseases can be used interchangeably [11].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
den Bosch, T. V., Dueholm, M., Leone, F. P., Valentin, L., Rasmussen, C. K., Votino, A., Schoubroeck, D. V., Landolfo, C., Installé, A., Guerriero, S., et al. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14806 · Cited by 776
Nonsteroidal anti-inflammatory drugs for dysmenorrhoea
Marjoribanks, J., Ayeleke, R. O., Farquhar, C. M., & Proctor, M. L. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001751.pub3 · Cited by 573
Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist
Taylor, H. S., Giudice, L. C., Lessey, B. A., Abrao, M. S., Kotarski, J., Archer, D. F., Diamond, M. P., Surrey, E., Johnson, N. P., Watts, N. B., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1700089 · Cited by 511
Naftalin, J., Hoo, W., Pateman, K., Mavrelos, D., Holland, T., & Jurkovic, D. (2012) · Human Reproduction · doi:10.1093/humrep/des332 · Cited by 337
Pathogenesis of adenomyosis, an update on molecular mechanisms
Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.06.016 · Cited by 326
Self-citationChwalisz, K., Perez, M. C., DeManno, D., Winkel, C., Schubert, G., & Elger, W. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0001 · Cited by 310
Kitawaki, J., Noguchi, T., Amatsu, T., Maeda, K., Tsukamoto, K., Yamamoto, T., Fushiki, S., Osawa, Y., & Honjo, H. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.3.514 · Cited by 305
Chapron, C., Tosti, C., Marcellin, L., Bourdon, M., Lafay-Pillet, M.-C., Millischer, A.-E., Streuli, I., Borghese, B., Petraglia, F., & Santulli, P. (2017) · Human Reproduction · doi:10.1093/humrep/dex088 · Cited by 294
Self-citationEffects of adenomyosis on in vitro fertilization treatment outcomes: a meta-analysis
Younes, G., & Tulandi, T. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.06.025 · Cited by 272
Khan, K. N., Kitajima, M., Hiraki, K., Fujishita, A., Sekine, I., Ishimaru, T., & Masuzaki, H. (2009) · Human Reproduction · doi:10.1093/humrep/dep437 · Cited by 269
Imaging for the evaluation of endometriosis and adenomyosis
Exacoustós, C., Manganaro, L., & Zupi, E. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2014.04.010 · Cited by 258
Structural and molecular features of the endomyometrium in endometriosis and adenomyosis
Benagiano, G., Brosens, I., & Habiba, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmt052 · Cited by 246
Treatment of adenomyosis-associated menorrhagia with a levonorgestrel-releasing intrauterine device
Fedele, L., Bianchi, S., Raffaelli, R., Portuese, A., & Dorta, M. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)00245-8 · Cited by 242
Treatment of endometriosis with the antiprogesterone mifepristone (RU486)
Michael Kettel, L., Murphy, A. A., Morales, A. J., Ulmann, A., Baulieu, E. E., & Yen, S. S. C. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58022-4 · Cited by 216
Adenomyosis and Abnormal Uterine Bleeding (AUB-A)—Pathogenesis, diagnosis, and management
Abbott, J. A. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.09.006 · Cited by 209
Pinzauti, S., Lazzeri, L., Tosti, C., Centini, G., Orlandini, C., Luisi, S. V., Zupi, E., Exacoustós, C., & Petraglia, F. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.14834 · Cited by 208
Self-citationNonsteroidal anti-inflammatory drugs for heavy menstrual bleeding
Lethaby, A. E., Augood, C. A., & Duckitt, K. (1998) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000400 · Cited by 206
Uterine adenomyosis in the infertility clinic
Devlieger, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg010 · Cited by 206
Puente, J. M., Fabris, A. M., Patel, J., Patel, A., Cerrillo, M., Requena, A., & García-Velasco, J. A. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0185-6 · Cited by 205
Sheng, J., Zhang, W. Y., Zhang, J. P., & Lu, D. (2008) · Contraception · doi:10.1016/j.contraception.2008.11.004 · Cited by 202
Adenomyosis: a systematic review of medical treatment
Pontis, A., D’Alterio, M. N., Pirarba, S., de Angelis, C., Tinelli, R., & Angioni, S. L. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1197200 · Cited by 190
Bouchard, P., Chabbert‐Buffet, N., & Fauser, B. C. J. M. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.08.021 · Cited by 183
Sasagawa, S., Shimizu, Y., Kami, H., Takeuchi, T., Mita, S., Imada, K., Kato, S., & Mizuguchi, K. (2008) · Steroids · doi:10.1016/j.steroids.2007.10.003 · Cited by 177
The symptomatology of adenomyosis
Peric, H., & Fraser, I. S. (2006) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2006.01.006 · Cited by 171
Niu, Z., Chen, Q., Sun, Y., & Feng, Y. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.824960 · Cited by 167
Campo, S., Campo, V., & Benagiano, G. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2011.10.003 · Cited by 158
Ding, D., Liu, X., Duan, J., & Guo, S.-W. (2015) · Human Reproduction · doi:10.1093/humrep/dev025 · Cited by 139
Lazzeri, L., Di Giovanni, A., Exacoustos, C., Tosti, C., Pinzauti, S., Malzoni, M., Petraglia, F., & Zupi, E. (2014) · Reproductive Sciences · doi:10.1177/1933719114522520 · Cited by 137
Self-citationPark, C. W., Choi, M. H., Yang, K. M., & Song, I. O. (2016) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2016.43.3.169 · Cited by 137
Clinical effects of the levonorgestrel-releasing intrauterine device in patients with adenomyosis
Cho, S., Nam, A., Kim, H., Chay, D. B., Park, K., Cho, D. J., Park, Y., & Lee, B. S. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.10.798 · Cited by 135
Khan, K. N., Kitajima, M., Hiraki, K., Fujishita, A., Nakashima, M., Ishimaru, T., & Masuzaki, H. (2010) · Human Reproduction · doi:10.1093/humrep/deq240 · Cited by 132
Özdeğirmenci, Ö., Kayıkçıoğlu, F., Akgül, M. A., Kaplan, M., Karçaaltıncaba, M., Haberal, A., & Akyol, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.10.009 · Cited by 130
Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding
Lethaby, A. E., Duckitt, K., & Farquhar, C. M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000400.pub3 · Cited by 129
Shen, M., Liu, X., Zhang, H., & Guo, S.-W. (2015) · Human Reproduction · doi:10.1093/humrep/dev314 · Cited by 124
Osuga, Y., Fujimoto-Okabe, H., & Hagino, A. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.07.021 · Cited by 117
Characteristics indicating adenomyosis coexisting with leiomyomas: a case-control study
Taran, F., Weaver, A. L., Coddington, C. C., & Stewart, E. A. (2010) · Human Reproduction · doi:10.1093/humrep/deq034 · Cited by 115
Evidence for estrogen synthesis in adenomyotic tissues
Yamamoto, T., Noguchi, T., Tamura, T., Kitawaki, J., & Okada, H. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90654-2 · Cited by 111
Long-term management of adenomyosis with a gonadotropin-releasing hormone agonist: a case report
Nelson, J. R., & Corson, S. L. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55704-5 · Cited by 110
Ishihara, H., Kitawaki, J., Kado, N., Koshiba, H., Fushiki, S., & Honjo, H. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04813-6 · Cited by 110
Critchley, H., Wang, H., Kelly, R. W., Gebbie, A. E., & Glasier, A. F. (1998) · Human Reproduction · doi:10.1093/humrep/13.5.1210 · Cited by 108
Maruo, T., Laoag‐Fernandez, J. B., Pakarinen, P. I., Murakoshi, H., Spitz, I. M., & Johansson, E. D. B. (2001) · Human Reproduction · doi:10.1093/humrep/16.10.2103 · Cited by 107
Mijatovic, V., Florijn, E., Halim, N., Schats, R., & Hompes, P. G. A. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.02.047 · Cited by 106
Shaaban, O. M., Ali, M. K., Sabra, A. M. A., & Aal, D. E. M. A. E. (2015) · Contraception · doi:10.1016/j.contraception.2015.05.015 · Cited by 98
The uterine junctional zone: a 3-dimensional ultrasound study of patients with endometriosis
Exacoustós, C., Luciano, D. E., Corbett, B., Felice, G. D., Feliciantonio, M. D., Luciano, A. A., & Zupi, E. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.06.006 · Cited by 96
Treatment of adenomyosis with long-term GnRH analogues: a case report.
Grow, D. R., & Filer, R. B. (1991) · PubMed · Cited by 92
A pilot study on the off-label use of valproic acid to treat adenomyosis
Liu, X., & Guo, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.11.009 · Cited by 87
Novel conservative medical therapy for uterine adenomyosis with a danazol-loaded intrauterine device
Igarashi, M., Abe, Y., Fukuda, M., Ando, A., 宮坂, 牧., & Yoshida, M. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00624-5 · Cited by 87
Non-contraceptive health benefits of intrauterine hormonal systems
Fraser, I. S. (2010) · Contraception · doi:10.1016/j.contraception.2010.05.005 · Cited by 84
Pregnancy after medical therapy of adenomyosis with a gonadotropin-releasing hormone agonist
Hirata, J. D., Moghissi, K. S., & Ginsburg, K. A. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55703-3 · Cited by 81
Wagenfeld, A., Saunders, P. T. K., Whitaker, L. H. R., & Critchley, H. (2016) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2016.1180368 · Cited by 80
Live birth after treatment of severe adenomyosis with a gonadotropin-releasing hormone agonist
Silva, P. D., Perkins, H. E., & Schauberger, C. W. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56471-1 · Cited by 79
Immunosuppressive effects of danazol in vitro
Hill, J. A., Barbieri, R. L., & Anderson, D. J. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59408-4 · Cited by 77
Danazol for heavy menstrual bleeding
Beaumont, H. H., Augood, C. A., Duckitt, K., & Lethaby, A. E. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001017.pub2 · Cited by 75
An update on the pharmacological management of adenomyosis
Streuli, I., Dubuisson, J. B., Santulli, P., de Ziegler, D., Batteux, F., & Chapron, C. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.953055 · Cited by 75
Valproic Acid as a Therapy for Adenomyosis: A Comparative Case Series
Liu, X., Yuan, L., & Guo, S. (2010) · Reproductive Sciences · doi:10.1177/1933719110373807 · Cited by 67
Long‐term use of dienogest in the treatment of painful symptoms in adenomyosis
Osuga, Y., Watanabe, M., & Hagino, A. (2017) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13406 · Cited by 66
Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study
Hirata, T., Izumi, G., Takamura, M., Saito, A., Nakazawa, A., Harada, M., Hirota, Y., Koga, K., Fujii, T., & Osuga, Y. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.926882 · Cited by 64
Danazol: An antigonadotropic agent in the treatment of pelvic endometriosis
Lauersen, N. H., Wilson, K. H., & Birnbaum, S. J. (1975) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(75)90499-8 · Cited by 63
Kelekçi, S., Kelekçi, K. H., & Yılmaz, B. (2012) · Contraception · doi:10.1016/j.contraception.2012.04.001 · Cited by 63
Mao, X., Wang, Y., Carter, A. V., Zhen, X., & Guo, S. (2011) · Reproductive Sciences · doi:10.1177/1933719111404610 · Cited by 63
Fawzy, M., & Mesbah, Y. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3755-5 · Cited by 62
Wang, P., Yang, T., Lee, W.-L., Chao, H., Chang, S.-P., & Yuan, C. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00411-8 · Cited by 62
Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence
Zhu, B., Chen, Y., Shen, X., Liu, X., & Guo, S. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0198-1 · Cited by 61
Huang, B., Seow, K., Tsui, K., Huang, C.-Y., Lu, Y.-F., & Wang, P. (2012) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2012.04.008 · Cited by 60
Lin, J., Sun, C.-X., & Zheng, H. (2000) · PubMed · Cited by 60
Zhang, P., Song, K., Li, L., Yukuwa, K., & Kong, B. (2013) · Medical Principles and Practice · doi:10.1159/000351431 · Cited by 53
Lee, K. H., Kim, J. K., Lee, M. A., Ko, Y. B., Yang, J. B., Kang, B. H., & Yoo, H. J. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-016-4105-y · Cited by 53
Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis
Liu, X., & Guo, S. (2011) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01655.x · Cited by 52
Hormonal treatments for adenomyosis
Fedele, L., Bianchi, S., & Frontino, G. (2007) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2007.07.006 · Cited by 50
Igarashi, M. (1990) · Asia-Oceania Journal of Obstetrics and Gynaecology · doi:10.1111/j.1447-0756.1990.tb00207.x · Cited by 49
Kamada, Y., Nakatsuka, M., Asagiri, K., Noguchi, S., Habara, T., Takata, M., & Kudo, T. (2000) · Human Reproduction · doi:10.1093/humrep/15.12.2512 · Cited by 47
Partial suppression of estradiol: A new strategy in endometriosis management?
Donnez, J., Taylor, R. N., & Taylor, H. S. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.01.013 · Cited by 46
Ozaki, T., Takahashi, K., Okada, M., Kurioka, H., & Miyazaki, K. (1999) · PubMed · Cited by 45
Ota, H., Maki, M., SHIDARA, Y., Kodama, H., Takahashi, H., Hayakawa, M., Fujimori, R., Kushima, T., & Ohtomo, K. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)91433-1 · Cited by 43
Maia, H., Casoy, J., Correia, T., Freitas, L., Pimentel, K., Athayde, C., & Coutinho, E. M. (2006) · Gynecological Endocrinology · doi:10.1080/09513590601005375 · Cited by 43
Nagata, C., Yanagida, S., Okamoto, A., Morikawa, A., Sugimoto, K., Okamoto, S., Ochiai, K., & Tanaka, T. (2012) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2011.01778.x · Cited by 42
Okada, H., Okamoto, R., 都築, 朋., Tsuji, S., Yasuda, K., & Kanzaki, H. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.06.048 · Cited by 42
Elevated Immunoreactivity against Class I Histone Deacetylases in Adenomyosis
Liu, X., Nie, J., & Guo, S. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000336409 · Cited by 41
Influence of Dienogest on Ovulation in Young Fertile Women
Moore, C., Carol, W., Gräser, T., Mellinger, U., & Walter, F. (1999) · Clinical Drug Investigation · doi:10.2165/00044011-199918040-00003 · Cited by 39
Laoag‐Fernandez, J. B. (2003) · Human Reproduction · doi:10.1093/humrep/deg179 · Cited by 39
Kimura, F., Takahashi, K., Takebayashi, K., Fujiwara, M., Kita, N., Noda, Y., & Harada, N. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.09.010 · Cited by 37
Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age
Luisi, S. V., Razzi, S., Lazzeri, L., Bocchi, C., Severi, F. M., & Petraglia, F. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.017 · Cited by 35
Self-citationSelective progesterone receptor modulators
Whitaker, L. H. R., Williams, A. R. W., & Critchley, H. (2014) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000082 · Cited by 35
Yamanaka, A., Kimura, F., Kishi, Y., Takahashi, K., Suginami, H., Shimizu, Y., & Murakami, T. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.05.031 · Cited by 32
Expression of Apoptosis-Related Proteins in Adenomyotic Uteri Treated with Danazol and GnRH Agonists
Ueki, K., Kumagai, K., Yamashita, H., Li, Z., Ueki, M., & Otsuki, Y. (2004) · International Journal of Gynecological Pathology · doi:10.1097/01.pgp.0000130109.80359.57 · Cited by 30
Zhang, X., Yuan, H., Deng, L., Hu, F., Ma, J., & Lin, J. (2008) · Human Reproduction · doi:10.1093/humrep/den208 · Cited by 29
Danazol Suspension Injected into the Uterine Cervix of Patients with Adenomyosis and Myoma
TAKEBAYASHI, T., Fujino, Y., Umesaki, N., & Ogita, S. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000292410 · Cited by 29
Danazol for heavy menstrual bleeding
Beaumont, H. H., Augood, C. A., Duckitt, K., & Lethaby, A. E. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001017 · Cited by 29
Treatment strategies for pelvic pain associated with adenomyosis
Radzinsky, V. E., Khamoshina, M. B., Носенко, О. М., Духин, А. О., Sojunov, M. A., Оразмурадов, А. А., Lebedeva, М. G., & Orazov, M. R. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1232673 · Cited by 28
Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis
Takeuchi, A., Koga, K., Miyashita‐Ishiwata, M., Makabe, T., Sue, F., Harada, M., Hirata, T., Hirota, Y., Fujii, T., & Osuga, Y. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.10.053 · Cited by 28
Norethindrone Acetate in the Medical Management of Adenomyosis
Muneyyirci‐Delale, O., Chandrareddy, A., Mankame, S., Osei-Tutu, N., & von Gizycki, H. (2012) · Pharmaceuticals · doi:10.3390/ph5101120 · Cited by 27
Braun, D. P., Gebel, H. M., & Dmowski, W. P. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56821-6 · Cited by 27
Ekin, M., Cengiz, H., Ayağ, M. E., Kaya, C., Yaşar, L., & Savan, K. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.07.019 · Cited by 25
Akira, S., 峯, 克., Kuwabara, Y., & Takeshita, T. (2009) · PubMed · Cited by 25
Non-contraceptive benefits of intrauterine levonorgestrel administration: why not?
Sabbioni, L., Petraglia, F., & Luisi, S. V. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1334198 · Cited by 18
Self-citationDanazol: molecular, endocrine, and clinical pharmacology.
Rl, B. (1990) · PubMed · Cited by 17
Current and Future Medical Treatment of Adenomyosis
Tosti, C., Troìa, L., Vannuccini, S., Lazzeri, L., Luisi, S. V., & Petraglia, F. (2016) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000261 · Cited by 17
Self-citationLong-Term Vaginal Danazol Treatment in Fertile Age Women with Adenomyosis
Tosti, C., Vannuccini, S., Troìa, L., Luisi, S. V., Centini, G., Lazzeri, L., & Petraglia, F. (2017) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000270 · Cited by 16
Self-citationPrathoomthong, S., Tingthanatikul, Y., Lertvikool, S., Rodratn, N., Waiyaput, W., Dittharot, K., Sroyraya, M., & Sophonsritsuk, A. (2018) · PubMed Central · doi:10.22074/ijfs.2018.5137 · Cited by 16
The influence of mifepristone to caspase 3 expression in adenomyosis
Wang, Y., Jiang, X., & Wang, S. (2014) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog15872014 · Cited by 15
Non-contraceptive use of hormonal contraceptives
Schindler, A. E. (2008) · Gynecological Endocrinology · doi:10.1080/09513590802005562 · Cited by 10
Flagged first, then by citations
2 of the 103 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Badawy, 2012, Aromatase inhibitors or gonadotropin-releasing hormone agonists for the management of uterine adenomyosis: A randomized controlled trial. Acta Obstet Gynecol, Scand, 91, 489
Cited by
Sorted by citations
Diagnosing adenomyosis: an integrated clinical and imaging approach
Chapron, C., Vannuccini, S., Santulli, P., Abrão, M. S., Carmona, F., Fraser, I. S., Gordts, S., Guo, S., Just, P., Noël, J., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz049 · Cited by 439
Self-citationAdenomyosis: Mechanisms and Pathogenesis
Zhai, J., Vannuccini, S., Petraglia, F., & Giudice, L. C. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1716687 · Cited by 331
Self-citationRecent advances in understanding and managing adenomyosis
Vannuccini, S., & Petraglia, F. (2019) · F1000Research · doi:10.12688/f1000research.17242.1 · Cited by 298
Self-citationAdenomyosis incidence, prevalence and treatment: United States population-based study 2006–2015
Yu, O., Schulze-Rath, R., Grafton, J., Hansen, K., Scholes, D., & Reed, S. D. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.01.016 · Cited by 200
Progesterone Actions and Resistance in Gynecological Disorders
MacLean, J. A., & Hayashi, K. (2022) · Cells · doi:10.3390/cells11040647 · Cited by 199
Metadata
- Authors
- Vannuccini, S., Luisi, S., Tosti, C., Sorbi, F., & Petraglia, F.
- Affiliations
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Siena (IT)
- Corresponding author
- Petraglia, Felice
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 109
- Issue
- 3
- Pages
- 398-405
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2790094279
- Cited by
- 231
- References
- 103
- Citations by year
- 2026: 20 · 2025: 24 · 2024: 33 · 2023: 37 · 2022: 40 · 2021: 38 · 2020: 20 · 2019: 17 · 2018: 2
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- adenomyosis, medical therapy, hormone therapy, GnRH analogues, progestins, dienogest, danazol, norethindrone acetate, levonorgestrel intrauterine device, nonsteroidal anti-inflammatory drugs, abnormal uterine bleeding, dysmenorrhea, infertility, sex hormones, apoptosis, inflammation, selective progesterone receptor modulators, aromatase inhibitors, valproic acid, antiplatelet therapy
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Female, Fertility Agents, Female, Humans, Intrauterine Devices, Medicated, Gonadotropin-Releasing Hormone, Progestins, Uterine Diseases, Drugs, Investigational, Treatment Outcome, Adenomyosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
