Cited by 42Autophagy in Disease and TherapyFungal and yeast genetics researchEndoplasmic Reticulum Stress and Disease

Candida albicans autophagy, no longer a bystander: Its role in tolerance to ER stress-related antifungal drugs

Yu, Qilin, Jia, Chang, Dong, Yijie, Zhang, Bing, Xiao, Chenpeng, Chen, Yulu, Wang, Yuzhou, Li, Xiaoling +3 more·2015·Fungal Genetics and Biology

Abstract

Autophagy is a degradation process involved in pathogenicity of many pathogenic fungi. However, its roles in Candida albicans, the leading fungal pathogen in human beings, remain to be detailed. Most recently, we found that endoplasmic reticulum (ER) stress-inducing conditions led to transcriptional up-regulation of C. albicans autophagy-related (ATG) genes, implying a possible link between autophagy and ER stress response in this pathogen. Using a series of C. albicans ATG mutants and autophagy reporting systems, we found that both treatment of ER stress-related drugs and loss of the ER calcium pump Spf1 promoted autophagic flux of Atg8 and Lap41 (a homologue of Saccharomyces cerevisiae Ape1), indicating that these conditions induce autophagy. Moreover, deletion of ATG genes in the spf1Δ/Δ mutant rendered cells hypersensitive to these drugs and caused activation of UPR, revealing a role of autophagy in alleviating ER stress. In addition, only treatment of tunicamycin and loss of Spf1 in combination increased autophagic flux of the ER component Sec63, suggesting that most of the ER stress-related conditions cause non-selective autophagy rather than selective ER phagy. This study uncovers the important role of C. albicans autophagy in ER stress response and tolerance to antifungal drugs.

Integrity signals

Registry

Crossref · 10.1016/j.fgb.2015.02.008

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yu, Q., Jia, C., Dong, Y., Zhang, B., Xiao, C., Chen, Y., Wang, Y., Li, X., Wang, L., Zhang, B., & Li, M.
Affiliations
  • Nankai University (CN)
  • Tianjin University of Traditional Chinese Medicine (CN)
Corresponding author
Li, Mingchun
Venue
Fungal Genetics and Biology
Publisher
Elsevier BV
Published
2015-08
Volume
81
Pages
238-249
ISSN
1087-1845 (ISSN-L)
OpenAlex
W2004367369
Cited by
42
References
48
Citations by year
2026: 4 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 2
FWCI
3.40
Type
journal article
Language
en
Open access
closed
Locations
  • Fungal Genetics and Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China
  • China Postdoctoral Science Foundation
  • Fundamental Research Funds for the Central Universities
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Keywords
Candida albicans, autophagy, endoplasmic reticulum stress, antifungal drug tolerance, unfolded protein response, autophagy-related genes, autophagic flux, ER-phagy, tunicamycin, SEC63
MeSH terms
Antifungal Agents, Autophagy, Candida albicans, Endoplasmic Reticulum, Saccharomyces cerevisiae, Gene Deletion

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review