Mitogen-activated Protein Kinase Stimulation of Ca2+Signaling Is Required for Survival of Endoplasmic Reticulum Stress in Yeast

Bonilla, Myriam; Cunningham, Kyle W.

doi:10.1091/mbc.e03-02-0113

Cited by 165Fungal and yeast genetics researchEndoplasmic Reticulum Stress and DiseaseIon Channels and Receptors

Mitogen-activated Protein Kinase Stimulation of Ca2+Signaling Is Required for Survival of Endoplasmic Reticulum Stress in Yeast

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Bonilla, Myriam, Cunningham, Kyle W.·2003·Molecular Biology of the Cell

DOI 10.1091/mbc.e03-02-0113PMC PMC207020

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Abstract

Endoplasmic reticulum (ER) stress in the budding yeast Saccharomyces cerevisiae triggers Ca 2+influx through a plasma membrane channel composed of Cch1 and Mid1. This response activates calcineurin, which helps to prevent cell death during multiple forms of ER stress, including the response to azole-class antifungal drugs. Herein, we show that ER stress activates the cell integrity mitogen-activate protein kinase cascade in yeast and that the activation of Pkc1 and Mpk1 is necessary for stimulation of the Cch1-Mid1 Ca 2+channel independent of many known targets of Mpk1 (Rlm1, Swi4, Swi6, Mih1, Hsl1, and Swe1). ER stress generated in response to miconazole, tunicamycin, or other inhibitors also triggered a transient G2/M arrest that depended upon the Swe1 protein kinase. Calcineurin played little role in the Swe1-dependent cell cycle arrest and Swe1 had little effect on calcineurin-dependent avoidance of cell death. These findings help to clarify the interactions between Mpk1, calcineurin, and Swe1 and suggest that the calcium cell survival pathway promotes drug resistance independent of both the unfolded protein response and the G2/M cell cycle checkpoint.

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Treatment of fungal cells with azole antifungals led to an influx of extracellular Ca2+ that promoted the survival of fungi exposed to azole-induced stress.
“Treatment of fungal cells with azole antifungals led to an influx of extracellular Ca 2ϩ that promoted the survival of fungi exposed to azole-induced stress (16 -19).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [17]
In S. cerevisiae, activation of the Pkc1-mediated CWI pathway leads to increased synthesis of β-glucan and enhanced expression of Rlm1 and Swi4 targets including Fks2.
“In S. cerevisiae, activation of the Pkc1-mediated CWI pathway leads to an increased synthesis of ␤-glucan and enhanced expression of Rlm1 and Swi4 targets including Fks2 (49,50).”
From The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in Candida glabrata (2011) · cites this paper as [50]
There is broad conservation of cellular mechanisms to survive antifungal drug stress in fungal species.
“and suggest a broad conservation of cellular mechanisms to survive antifungal drug stress in fungal species.”
From The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in Candida glabrata (2011) · cites this paper as [50]

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Self-citation

Authors: Bonilla, M., & Cunningham, K. W.
Affiliations: Johns Hopkins University (US)
ORCID: Cunningham, Kyle W.
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2003-10
Volume: 14
Issue: 10
Pages: 4296-4305
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.e03-02-0113
PMC: PMC207020
OpenAlex: W2148652865
Cited by: 165
References: 68
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 9 · 2012: 9
FWCI: 2.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Biology of the Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM053082)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: endoplasmic reticulum stress, mitogen-activated protein kinase, Saccharomyces cerevisiae, calcineurin, Swe1, PKC1, Mpk1, G2/M cell cycle arrest, miconazole, tunicamycin, unfolded protein response, calcium signaling
MeSH terms: Antifungal Agents, Calcium, Cell Membrane, DNA-Binding Proteins, Endoplasmic Reticulum, Fungal Proteins, Membrane Glycoproteins, Mitosis, Protein Kinase C, Protein Kinases, Protein-Tyrosine Kinases, Saccharomyces cerevisiae, Transcription Factors, Calcium Channels, Signal Transduction, G2 Phase, Cell Death, Protein Tyrosine Phosphatases, Protein Serine-Threonine Kinases, Protein Folding, Cell Cycle Proteins, Calcineurin, ras-GRF1, Mitogen-Activated Protein Kinases, MADS Domain Proteins, Saccharomyces cerevisiae Proteins

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Mitogen-activated Protein Kinase Stimulation of Ca2+Signaling Is Required for Survival of Endoplasmic Reticulum Stress in Yeast

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