Cited by 143Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

Mechanism of Candida pathogenesis: Revisiting the vital drivers

Mba, Ifeanyi Elibe, Nweze, Emeka Innocent·2020·European Journal of Clinical Microbiology & Infectious Diseases

Abstract

Candida is the most implicated fungal pathogen in the clinical setting. Several factors play important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits, morphological and phenotypic switching, biofilm formation, tissue damaging extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, adaptation to environmental pH fluctuation, robust nutrient acquisition system, adherence and invasions (mediated by adhesins and invasins), heat shock proteins (HSPs), cytolytic proteins, escape from phagocytosis, evasion from host immune system, synergistic coaggregation with resident microbiota, resistance to antifungal agents, and the ability to efficiently respond to multiple stresses are some of the major pathogenic determinants of Candida species. The existence of multiple connections, in addition to the interactions and associations among all of these factors, are distinctive features that play important roles in the establishment of Candida infections. This review describes all the underlying factors and mechanisms involved in Candida pathogenesis by evaluating pathogenic determinants of Candida species. It reinforces the already available pool of data on the pathogenesis of Candida species by providing a clear and simplified understanding of the most important factors implicated in the pathogenesis of Candida species. The Candida pathogenesis network, an illustration linking all the major determinants of Candida pathogenesis, is also presented. Taken together, they will further improve our current understanding of how these factors modulate virulence and consequent infection(s). Development of new antifungal drugs and better therapeutic approaches to candidiasis can be achieved in the near future with continuing progress in the understanding of the mechanisms of Candida pathogenesis.

Integrity signals

Registry

Crossref · 10.1007/s10096-020-03912-w

Cites

230 of 230 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Frequent drug targets are formation of hyphae, aspartyl proteinases, and phospholipase enzymes.

    “Indeed, frequent drug targets are the formation of hyphae, which is one of the first steps in biofilm formation, the enzymes aspartyl proteinases, key virulence factors able to degrade many human proteins (i.e., mucin, immune system molecules, endothelial cell proteins, and coagulation factors), and phospholipase enzymes, proteins able to break the ester bonds of phospholipids, inducing cell lysis”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Mba, I. E., & Nweze, E. I.
Affiliations
University of Nigeria (NG)
Corresponding author
Nweze, Emeka Innocent
Venue
European Journal of Clinical Microbiology & Infectious Diseases
Published
2020-05-06
Volume
39
Issue
10
Pages
1797-1819
ISSN
  • 0934-9723 (ISSN-L)
  • 1435-4373
OpenAlex
W3021920646
Cited by
143
References
230
Citations by year
2026: 13 · 2025: 35 · 2024: 26 · 2023: 29 · 2022: 19 · 2021: 16 · 2020: 4 · 2019: 1
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida, fungal pathogenesis, virulence factors, candidiasis, morphological switching, biofilm formation, extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, pH adaptation, nutrient acquisition, adhesins, invasin, heat shock proteins, cytolytic proteins, phagocytosis evasion, immune evasion, antifungal resistance, stress response
MeSH terms
Antifungal Agents, Candida, Candidiasis, Humans, Drug Resistance, Fungal, Virulence Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review